Variability of detrusor overactivity on repeated filling cystometry in men with urge symptoms: comparison with spinal cord injury patients

Ockrim, Jeremy; Laniado, Marc; Khoubehi, Bijan; Renzetti, Roberto; Agrò, Enrico Finazzi; Carter, Simon S.; Tubaro, Andrea

doi:10.1111/j.1464-410x.2005.05344.x

Cited by 41 publications

(41 citation statements)

References 25 publications

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“…In this context, epidemiology may be especially useful, for example: ageing is associated with a rising prevalence of overactive bladder (OAB) syndrome; 1 bladder outflow tract obstruction (BOO) is associated with a high prevalence of LUTS; 2 neurological lesions are associated with a high prevalence of detrusor overactivity but not necessarily with urgency. 3 (ii) Describe the most useful current, clinical measurements that quantify the clinical problem so that animal data may be used to translate their findings to the human condition. (iii) Describe the aetiology or pathophysiology in human tissues and organs obtained from patients, for example, why does the bladder become overactive or why does the urethral sphincter become insufficient.…”

mentioning

confidence: 99%

Animal models and their use in understanding lower urinary tract dysfunction

Fry

Daneshgari

Thor³

et al. 2010

Neurourology and Urodynamics

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This review will highlight appropriate animal models for the study of a number of disorders involving changes to lower urinary tract function. A major hurdle to the development of animal models for human lower urinary tract disorders is that the clinical pathophysiology of the latter mostly remain idiopathic. Acute injury/inflammation of otherwise healthy animals has often been used to study effects on a target tissue/organ. However, these "acute" models may not adequately address the characteristics of "chronic" visceral disorders. In addition, the relevance of observed changes following acute injury/inflammation, in terms of possible therapeutic targets, may not reflect that which occurs in the human condition. We have therefore emphasized the situations when animal models are required to investigate lower urinary tract disorders and what they should set out to achieve. In particular we have discussed the merits and disadvantages of a number of paradigms that set out to investigate specific lower urinary tract disorders or situations associated with these conditions. These include animal models of overactive bladder, stress urinary incontinence, ageing and congenital defects of the urinary tract and bladder pain syndrome.

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mentioning

confidence: 99%

Animal models and their use in understanding lower urinary tract dysfunction

Fry

Daneshgari

Thor³

et al. 2010

Neurourology and Urodynamics

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“…For this reason, common examination methods, such as the urodynamics test and the sympathetic skin response, cannot be used in rats. 32,33 In recent years, Blok et al 34 determined bladder function by using positron emission tomography to detect the changes in neuronal excitability of the frontal lobe and cingulate gyrus during bladder filling. It remains to be determined whether this technique can be used in the experiment type described here.…”

Section: Immunocytochemistrymentioning

confidence: 99%

Reconstruction of atonic bladder innervation after spinal cord injury: A bladder reflex arc with afferent and efferent pathways

Luo

et al. 2015

The Journal of Spinal Cord Medicine

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Background: Establishing bladder reflex arcs only with the efferent pathway to induce micturition after spinal cord injury (SCI) has been successful. However, the absence of sensory function and micturition desires can lead to serious complications. Objectives: To reconstruct a bladder reflex arc with both afferent and efferent pathways to achieve atonic bladder innervation after SCI. Methods: A reflex arc was established by microanastomosis of the S2 dorsal root to the peripheral process of the L5 dorsal ganglion and the L5 ventral root to the S2 ventral root. The functions of the reflex arc were evaluated using electrophysiology, wheat germ agglutinin-horseradish peroxidase (WGA-HRP) tracing, and calcitonin gene-related peptide (CGRP) immunocytochemistry analysis. Hind-paw motion was evaluated by CatWalk gait. Results: Compound action potentials and compound muscle action potentials were recorded at the right L5 dorsal root following electrical stimulation of right S2 dorsal root. Similar to the control side, these were not significantly different before or after the spinal cord destruction between L6 and S4. WGA-HRP tracing and CGRP immunocytochemistry showed that construction of the afferent and efferent pathways of the bladder reflex arc encouraged axonal regeneration of motor and sensory nerves, which then made contact with the anterior and posterior horns of the spinal cord, ultimately reestablishing axoplasmic transportation. Gait analysis showed that at 3 months following the operation, only the regularity index was significantly different as compared with 1 day before the operation, other parameters showing no difference. Conclusion: Bladder reflex arc with the afferent and efferent pathways reconstructs the micturition function without great influence on the motion of leg.

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“…However, we do not think that repeated cystometries had a major effect on the increased capacity in the intermittent filling cystometry as Thyberg et al (12) found no significant difference between the mean maximum detrusor pressure in the first and second cystometries compared with the third and fourth cystometries, which were performed with 10 minutes intervals between them in a SCI population with overactive detrusors. Similarly, Ockrim et al performed 3 sequential cystometries in men with SCI and reported that cystometric variables and detrusor overactivity remained consistent over sequential studies (13).…”

Section: R Re Es Su Ul Lt Ts Smentioning

confidence: 99%

Comparison of Continuous and Intermittent Filling Cystometry in Patients with Spinal Cord Injury

Kaya¹,

Ersöz²,

Koyuncu³

et al. 2010

tftr

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S Su um mm ma ar ry y O Ob bj je ec ct ti iv ve e: : Continuous medium filling cystometry at a rate of 50 ml/min is a widely used method due to its advantages such as short filling time and published reference values. However, this type of filling sometimes provokes detrusor contractions and may cause incorrect bladder capacity determinations. The aim of this study was to compare the continuous and intermittent filling during cystometry in patients with spinal cord injury (SCI) who had detrusor overactivity. M Ma at te er ri ia al ls s a an nd d M Me et th ho od ds s: : Twenty patients with SCI who had detrusor overactivity were included in the study. After the drainage of all urine, first, the bladder was filled continuously at a filling rate of 50 ml/min with sterile physiological saline at room temperature and the maximum cystometric capacity was determined. After the continuous filling cystometry, the bladder was emptied again and filled intermittently by 30 seconds filling followed by 15 seconds pause periods at filling rate of 50 ml/min. The maximum cystometric capacities observed during continuous and intermittent filling were compared by the Wilcoxon signed rank test. R Re es su ul lt ts s: : The mean maximum cystometric capacities were 86.5±43.7 ml and 122.7±62.2 ml, respectively in continuous and intermittent filling (p<0.001). The mean increase in intermittent filling was 36.2±38.1 ml, which represented a 41.84% mean increase. C Co on nc cl lu us si io on n: : In this study, higher cystometric capacities were observed in SCI patients with overactive detrusors by intermittent filling. This method may serve determination of bladder capacity more correctly and may contribute to make appropriate therapeutic decisions in patients with detrusor overactivity. Turk J Phys Med Rehab 2010;56:67-70. K Ke ey y W Wo or rd ds s: : Intermittent filling, cystometry, spinal cord injury, overactive urinary bladder Ö Öz ze et t A Am ma aç ç: : Elli ml/dk h›zda yap›lan orta h›zl› sürekli dolum sistometrisi dolum süresinin k›sal›¤› ve yay›nlanm›fl referans de¤erlerinin oluflu gibi avantajlar› nedeniyle yayg›n olarak kullan›lan bir metotdur. Bununla birlikte bu tip dolum bazen detrüsör kontraksiyonlar›n› provoke edebilir ve mesane kapasitesini saptamada hatalara neden olabilir. Bu çal›fl-man›n amac› afl›r› aktif detrüsöre sahip omurilik yaralanmal› (OY) hastalarda sürekli ve aral›kl› dolumla yap›lan sistometrik ölçümlerin karfl›-laflt›r›lmas›d›r. G Ge er re eç ç v ve e Y Yö ön nt te em m: : Çal›flmaya afl›r› aktif detrüsöre sahip OY'li 20 hasta dahil edildi. Mesanedeki tüm idrar boflalt›ld›ktan sonra, mesane ilk ön-ce oda s›cakl›¤›ndaki steril serum fizyolojik ile 50 ml/dk h›zla sürekli olarak dolduruldu ve mesane kapasitesi belirlendi. Sürekli dolum sistometrisinden sonra mesane tekrar boflalt›ld› ve 50 ml/dk dolum h›z›yla 30 saniyelik dolum periyodlar›n› izleyen 15 saniyelik duraklamalarla aral›kl› olarak dolduruldu. Sürekli ve aral›kl› dolum s›ras›nda saptanan kapasiteler Wilcoxon iflaretli s›ra testi ile karfl›laflt›r›...

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Variability of detrusor overactivity on repeated filling cystometry in men with urge symptoms: comparison with spinal cord injury patients

Cited by 41 publications

References 25 publications

Animal models and their use in understanding lower urinary tract dysfunction

Animal models and their use in understanding lower urinary tract dysfunction

Reconstruction of atonic bladder innervation after spinal cord injury: A bladder reflex arc with afferent and efferent pathways

Comparison of Continuous and Intermittent Filling Cystometry in Patients with Spinal Cord Injury

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