This paper examines the effectiveness of sustainable warehouse design with regard to fire regulations and costs. When designing industrial facilities, the high risk of fire during their subsequent operation must be considered. Therefore, in this article, the variant analysis in terms of cost and technological, sustainable solutions for the investment in the “design and build” system were subjected to fire protection installation systems for three variants with different fire zones. During the modelling, the impact of the fire zone on the spread of smoke, temperature changes at a selected point above the fire source, and visibility were examined. Numerical analyses showed differences in the degree of smoke spread for variants I, II, and III without any relevant impact on the effectiveness of evacuation. The division of the hall into a larger number of fire zones reduces the effects of a potential fire. This study highlights that the cost of the investment is vastly influenced by the conditions of fire protection and evacuation.