Variability of breathing during wakefulness while using CPAP predicts adherence

Abstract

At the initiation of therapy, breathing regularity during wakefulness while wearing CPAP is an objective predictor of short-term CPAP adherence.

Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea

“…15,43 Despite the emerging evidence suggesting that physiologic OSA traits can predict response to CPAP-alternative treatments (ie, oral appliances, upper airway surgery), 44,45 little is known about whether these traits affect CPAP tolerance or adherence. Fujita et al 46 showed that increased breathing irregularity while awake (defined by coefficient of variation in tidal volume > 34.0) predicted poor CPAP adherence at 1 month. Gray et al assessed the ArTH in a small group of patients with OSA who were recommended to receive CPAP treatment (n = 94), 14 and in multivariate analyses a low ArTH was not associated with CPAP use at follow-up (up to 22 months).…”

Year in review 2017: Interstitial lung disease, pulmonary vascular disease and sleep

“…Some progress has been made in this area with surrogate measures of physiological traits discernible from awake breathing measures, PSG data and therapeutic CPAP levels . Similarly, breathing regularity during CPAP acclimation is predictive of subsequent CPAP adherence . This phenotypic approach to OSA holds the possibility of altering our assessment and treatment paradigm and fits in well with the P4 approach to personalized health care (Fig.…”

Mining Knowledge of Respiratory Rate Quantification and Abnormal Pattern Prediction

“…Our study indicates that the granularity concept applied to respiratory rate quantification and abnormal pattern prediction might provide novel insights into cardiorespiratory regulation beyond those offered by a simple analysis of respiratory rate, inspiration and expiration times, tidal volume assessment, or their variability [ 48 , 49 ]. Many previous studies concerning respiratory variability have been performed in animals and cannot be directly translated to humans [ 50 , 51 ].…”