Variability in the Recurrence Rate at First Follow-up Cystoscopy after TUR in Stage Ta T1 Transitional Cell Carcinoma of the Bladder: A Combined Analysis of Seven EORTC Studies

Brausi, Maurizio; Collette, Laurence; Kurth, K. H.; Meijden, Adrian P. van der; Oosterlinck, W; Witjes, J. Alfred; Newling, D. W. W.; Bouffioux, C; Sylvester, Richard

doi:10.1016/s0302-2838(02)00068-4

Cited by 590 publications

(357 citation statements)

References 18 publications

Supporting

Mentioning

317

Contrasting

Unclassified

Order By: Relevance

“…Several publications have focused on the high recurrence rate at the first follow-up cystoscopy after TUR due to an incomplete resection or residual tumor [37][38][39]. There is thus justification for giving an early intense schedule of instillations to eradicate residual tumor after TUR.…”

Section: Discussionmentioning

confidence: 99%

The Schedule and Duration of Intravesical Chemotherapy in Patients with Non–Muscle-Invasive Bladder Cancer: A Systematic Review of the Published Results of Randomized Clinical Trials

2008

Self Cite

View full text Add to dashboard Cite

Objectives-Intravesical chemotherapy has been studied in randomized clinical trials for >30 yr; however, the optimal schedule and duration of treatment are unknown. The objective is to determine the effect of schedule and duration of intravesical chemotherapy on recurrence in patients with stage Ta T1 bladder cancer.Methods-A systematic review was conducted of the published results of randomized clinical trials that compared intravesical instillations with respect to their number, frequency, timing, duration, dose, or dose intensity.

show abstract

Section: Discussionmentioning

confidence: 99%

The Schedule and Duration of Intravesical Chemotherapy in Patients with Non–Muscle-Invasive Bladder Cancer: A Systematic Review of the Published Results of Randomized Clinical Trials

2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…There is increasing consensus that so called early recurrence may in fact arise from residual tumor left behind at resection or from the growth of previously undetected microscopic lesions. (Brausi et al, 2002;Filbeck et al, 2002;Babjuk et al, 2005;Jocham et al, 2005;Mostafid and Brausi, 2012).…”

Section: Introductionmentioning

confidence: 99%

Feasibility of Photodynamic Diagnosis for Challenging TUR-Bt Cases Including Muscle Invasive Bladder Cancer, BCG Failure or 2^nd-TUR

Takai¹,

Inamoto²,

Komura³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: Despite widely adopted standard methods for follow-up including cystoscopy plus cytology, recurrence rates of non muscle-invasive bladder cancer (NMIBC) have not improved over the past decades, still ranging from 60% through 70%. Hence, widely acceptable surveillance strategies with excellent sensitivity are needed. Early recurrence has led to the development of a novel cystoscopy technique utilizing photodynamic diagnosis (

show abstract

“…It should be noted that TUR is an oncologic surgery and the principles of major operations should be taken into consideration for TUR as well. High-quality TUR has been first suggested in studies conducted by the EORTC, and its impact on the accurate staging and subsequent recurrence has been highlighted (9). Considering particularly the fact that about 75% of patients have non-muscle-invasive bladder tumor which can be completely cured by a quality TUR; the importance of the procedure is manifested (6).…”

Section: Discussionmentioning

confidence: 99%

“…Although these figures vary between clinics, this variance was attributed to the quality of TUR and the importance of high quality TUR was underlined in the study by The European Organisation for Research and Treatment of Cancer (EORTC) (9). The recurrence after first cystoscopy is rather attributed to the quality of previous TUR and overlooked tumor cells rather than tumor biology (6,9,10).…”

Section: Introductionmentioning

confidence: 99%

Influence of the Presence of Muscularis Propria on Recurrence and the Quality of Transurethral Resection in Low-Grade, Stage pTa Bladder Tumors

Türk¹,

Ün²,

Tarhan³

et al. 2016

jus

View full text Add to dashboard Cite

ÖZ AmaçYeni kasa invaze olmayan mesane tümörlerinin standart tedavisi mesanenin transüretral rezeksiyonu (TURM) ve intravezikal kemoterapidir. Yetersiz tümör rezeksiyonu, erken nüks ve düşük evreleme gibi hastalığın seyrini değiştirecek durumları ortaya çıkarmaktadır. Bu nedenle kasa invaze olmayan mesane tümörlerinin tedavisinde kaliteli TURM önemli bir faktördür. gereç ve yöntemPrimer mesane tümörü nedeniyle TURM olmuş 841 hasta çalışmaya alındı. Toplam 597 hasta bu kriterlerimize uymadığı için çalışmadan çıkarıldı. Grup 1'de patoloji spesmeninde müskülaris propria (MP) görülen hastalar bulunurken; grup 2, TURM örneğinde MP görülmeyen hastalardan oluşmuştur. Hastalar; cinsiyet, tümör sayısı, patoloji spesmenindeki tümör hacmi, MP durumu, nüks durumu, nüks zamanı ve progresyon açısından değerlendirildi. BulgularNüks eden 92 hastanın sadece 14'ünde (%15,2) MP bulunurken geriye kalan 78 (%84,8) hasta da MP görülmemiştir (p=0,004). Grup 1'de progrese olan hasta 4 (%14,2), grup 2'de 28 (%29) hasta olarak ortaya çıkmıştır (p=0,159). Tek değişkenli analizde, tümör multiplitesi (p=0,003) ve MP yokluğu (p=0,004) rekürrens üzerine etkili bulunmuştur. Çok değişkenli analizde yine bu iki parametre nüks üzerine etkili bulunmuştur (p=0,004). objectiveTransurethral resection (TUR) of the bladder and intravesical chemotherapy is the standard treatment option for non-muscle-invasive bladder tumors. Inadequate tumor resection results in early recurrence and staging inaccuracies, which all will change the course of the disease. High-quality TUR treatment is therefore an important factor in the treatment of non-muscle-invasive bladder tumors. In this study, we investigated the significance of detecting the presence of muscularis propria (MP) in pathology specimens of low-grade, stage pTa tumors in patients who were treated with TUR due to primary bladder tumors, with regard to recurrence, time to recurrence and progression. Materials and MethodsInitially, 841 patients who were treated with TUR due to primary bladder tumors were enrolled in the study. A total of 597 patients were excluded from the study because they failed to meet the study criteria. Group 1 consisted of patients with MP detected in the pathology specimens; whereas group 2 consisted of patients whose TUR specimens did not include MP. The patients were evaluated with regard to gender, tumor number, presence or absence of MP, and recurrence status. ResultsMP was observed in only 14 (15.2%) of 92 patients with recurrence, but not in the remaining 78 (84.8%) (p=0.004). Progression occurred in 4It was pointed out that muscularis propria presence in the pathology specimens of low-grade stage pTa tumours is an indicator of a high quality transurethral resection.

show abstract

Variability in the Recurrence Rate at First Follow-up Cystoscopy after TUR in Stage Ta T1 Transitional Cell Carcinoma of the Bladder: A Combined Analysis of Seven EORTC Studies

Cited by 590 publications

References 18 publications

The Schedule and Duration of Intravesical Chemotherapy in Patients with Non–Muscle-Invasive Bladder Cancer: A Systematic Review of the Published Results of Randomized Clinical Trials

The Schedule and Duration of Intravesical Chemotherapy in Patients with Non–Muscle-Invasive Bladder Cancer: A Systematic Review of the Published Results of Randomized Clinical Trials

Feasibility of Photodynamic Diagnosis for Challenging TUR-Bt Cases Including Muscle Invasive Bladder Cancer, BCG Failure or 2^nd-TUR

Influence of the Presence of Muscularis Propria on Recurrence and the Quality of Transurethral Resection in Low-Grade, Stage pTa Bladder Tumors

Contact Info

Product

Resources

About

Variability in the Recurrence Rate at First Follow-up Cystoscopy after TUR in Stage Ta T1 Transitional Cell Carcinoma of the Bladder: A Combined Analysis of Seven EORTC Studies

Cited by 590 publications

References 18 publications

The Schedule and Duration of Intravesical Chemotherapy in Patients with Non–Muscle-Invasive Bladder Cancer: A Systematic Review of the Published Results of Randomized Clinical Trials

The Schedule and Duration of Intravesical Chemotherapy in Patients with Non–Muscle-Invasive Bladder Cancer: A Systematic Review of the Published Results of Randomized Clinical Trials

Feasibility of Photodynamic Diagnosis for Challenging TUR-Bt Cases Including Muscle Invasive Bladder Cancer, BCG Failure or 2nd-TUR

Influence of the Presence of Muscularis Propria on Recurrence and the Quality of Transurethral Resection in Low-Grade, Stage pTa Bladder Tumors

Contact Info

Product

Resources

About

Feasibility of Photodynamic Diagnosis for Challenging TUR-Bt Cases Including Muscle Invasive Bladder Cancer, BCG Failure or 2^nd-TUR