Variability in perisylvian brain anatomy in healthy adults

Knaus, Tracey A.; Bollich, Angela M.; Corey, David M.; Lemen, Lisa; Foundas, Anne L.

doi:10.1016/j.bandl.2005.10.008

Cited by 47 publications

(38 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Heschl's gyrus lies on the plane of the STG, a region found to have small volumes in males with SPD Downhill et al, 2001), and in females with SPD with a family history of mental illness (Dickey et al, 2003). Of particular interest to this report, however, Heschl's gyrus is noted to have marked inter-subject morphometric volume and shape variability (Leonard et al, 1998;Knaus et al, 2006), thus complicating the interpretation of volume data (Knaus et al, 2006).…”

Section: Introductionmentioning

confidence: 82%

“…In the current report the more posterior transverse gyri may not have been included. Fifth, there is marked intersubject and even inter-hemispheric variability of the STG, particularly, Heschl's gyrus (Lange et al, 1997;Leonard et al, 1998;Sweet et al, 2005;Knaus et al, 2006). To clarify, it is quite common for there to be two parallel transverse or Heschl's gyri (Knaus et al, 2006;Sweet et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Second, only male subjects were included in this study. Future work will need to include females to test whether there is a gender effect (Dickey et al, 2003;Knaus et al, 2006). This is particularly critical as our laboratory recently completed a pitch MMN investigation in a group of male and female SPD individuals and the results suggest that there is no impairment of early sensory processing as indexed by MMN in males.…”

Section: Discussionmentioning

confidence: 99%

“…With the use of Slicer software (www.slicer.org) one could now visualize whether there was a single transverse gyrus, a common medial stem branching to two more laterally in which case both would be included per Steinmetz's criteria (Steinmetz et al, 1986), or two medial stems joining more laterally in which case only the more anterior portion would be selected. This ability to visualize and draw in three dimensions represents a significant technological advancement compared with previous capabilities and is important given the marked inter-subject and even inter-hemispheric variability of this gyrus (Knaus et al, 2006). Volumes were corrected for total intracranial contents using a regression procedure (Dickey et al, 2002a,b).…”

Section: Structural Mrimentioning

confidence: 99%

See 3 more Smart Citations

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Dickey

Mórocz

Niznikiewicz

et al. 2008

Schizophrenia Research

View full text Add to dashboard Cite

Background-One of the cardinal features of schizotypal personality disorder (SPD) is language abnormalities. The focus of this study was to determine whether or not there are also processing abnormalities of pure tones differing in pitch and duration in SPD.Methods-Thirteen neuroleptic-naïve male subjects met full criteria for SPD and were groupmatched on age and parental socioeconomic status to 13 comparison subjects. Verbal learning was measured with the California Verbal Learning Test. Heschl's gyrus volumes were measured using structural MRI. Whole-brain fMRI activation patterns in an auditory task of listening to tones including pitch and duration deviants were compared between SPD and control subjects. In a Contributors Dickey: designed the study, collected the fMRI data, analyzed the clinical and fMRI data, and wrote the manuscript. Morocz: analyzed the fMRI data. Niznikiewicz: collected and analyzed the ERP data, and contributed to the manuscript. Voglmaier: collected and analyzed CVLT data, and performed SCID interview. Dreusicke: analyzed the fMRI data. Toner: aided in fMRI data collection. Yoo: aided in initial fMRI data collection. Khan: aided in final fMRI data presentation. Shenton: reviewed the manuscript. McCarley: reviewed the manuscript. Conflict of interestAll authors declare that they have no conflict of interest. Results-In the region of the STG, SPD subjects demonstrated more activation to pitch deviants bilaterally (p<0.001); and to duration deviants in the left hemisphere (p=0.005) (two-sample t). SPD subjects also showed more bilateral parietal cortex activation to duration deviants. In no region did comparison subjects activate more than SPD subjects in either experiment. Exploratory correlations for SPD subjects suggest a relationship between peak activation on the right for deviant tones in the pitch experiment with odd speech and impaired verbal learning. There was no difference between groups on Heschl's gyrus volume. NIH Public AccessConclusions-These data suggest that SPD subjects have inefficient or hyper-responsive processing of pure tones both in terms of pitch and duration deviance that is not attributable to smaller Heschl's gyrus volumes. Finally, these auditory processing abnormalities may have significance for the odd speech heard in some SPD subjects and downstream language and verbal learning deficits.

show abstract

Section: Introductionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Structural Mrimentioning

confidence: 99%

See 2 more Smart Citations

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Dickey

Mórocz

Niznikiewicz

et al. 2008

Schizophrenia Research

View full text Add to dashboard Cite

show abstract

“…Furthermore, cerebral asymmetry patterns may have different symptoms according to the affected hemisphere (Knaus et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Morphological Aspects of the Inferior Frontal Gyrus and its Relations with Brain Hemispheres and Gender: A Study with <i>in vivo</i> Magnetic Resonance Imaging

Georgeto¹,

Gariba²,

Aguiar³

2016

American Journal of Neuroscience

View full text Add to dashboard Cite

This study aims to evaluate the reliability of an anatomytopographic location method for the anatomical references that form the inferior frontal gyrus and compare the findings of both studied brain hemisphere as well as the genre. Two different pulse sequences-gradient-echo T1 (T1 GRE) and reversal recovery gradient-echo T1 (T1 IR GRE) were used for such purpose. The sample consisted of 30 healthy individuals with a mean age 25.3±7.04 years, 16 women (53%) and 14 men (46%). A methodology adapted to identify the limits of the structure forming the inferior frontal gyrus was used. The reliability of the method was evaluated by the level of agreement on intra-examiner and inter-examiner analysis. There was a satisfactory degree of agreement-good, very good or excellent for most references evaluated both on intra-observer and inter-observer analysis. The only exception was the left orbital part on intra -examiner analysis in T1 IR GRE (Kappa test, p>0, 05). No differences were observed between the findings regarding gender. When evaluating the performance between sequences T1 GRE performed better in the independent identification of the structures of the analyzed hemispheres (Kappa test technique Jackniffe, p<0.05). The method proved to be reliable for identifying the structures that make up the inferior frontal gyrus. There was no difference between the morphological aspects related to brain hemisphere and gender. Comparing the performance of the sequences, T1 GRE functioned better. However, further studies are needed to confirm such findings.

show abstract

What the Speaking Brain Tells us about Functional Imaging

Sidtis

2012

The Handbook of the Neuropsychology of Language

View full text Add to dashboard Cite

Variability in perisylvian brain anatomy in healthy adults

Cited by 47 publications

References 94 publications

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Morphological Aspects of the Inferior Frontal Gyrus and its Relations with Brain Hemispheres and Gender: A Study with <i>in vivo</i> Magnetic Resonance Imaging

What the Speaking Brain Tells us about Functional Imaging

Contact Info

Product

Resources

About