Variability in Individual Native Fibrin Fiber Mechanics
Christine C. Helms
Abstract:Fibrin fibers are important structural elements in blood coagulation. They form a mesh network that acts as a scaffold and imparts mechanical strength to the clot. A review of published work measuring the mechanics of fibrin fibers reveals a range of values for fiber extensibility. This study investigates fibrinogen concentration as a possible variable responsible for variability in fibrin fiber mechanics. It expands previous work to describe the modulus, strain hardening, extensibility, and the force required… Show more
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