Variability in HIV-1 partial genomic sequences in Costa Rican patients: analysis with different bioinformatics tools

Taylor-Castillo, Lizeth; León-Bratti, María Paz; Solano-Chinchilla, Antonio; Herrera-Martínez, Gisela; Boza-Cordero, Ricardo; León, Bernal; Luftig, Ronald B.; Visoná, Kirsten A.

doi:10.1590/s1020-49892010000100004

Cited by 7 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The findings show that subtype B is predominant in the region, which is congruent with reports from neighboring countries such as Mexico, Colombia, and Venezuela (45)(46)(47), as well as smaller reports from Central America (14)(15)(16)(17). Interestingly, however, while HIV-1 group M subtype B strains worldwide usually intermix in a star-like phylogeny, indicative of the panmictic structure of the epidemic, strains from Central America appeared to be highly compartmentalized.…”

Section: Discussionsupporting

confidence: 83%

See 1 more Smart Citation

A Single Early Introduction of HIV-1 Subtype B into Central America Accounts for Most Current Cases

Murillo

Véras

Prosperi

et al. 2013

J Virol

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 83%

“…HIV-1 group M subtype B dominates the epidemics in North America and Western and Central Europe, whereas subtype B and BF recombinants predominate in South America (13). The information on the molecular epidemiology of HIV-1 in Central America is still limited, but available data suggest that HIV-1 group M subtype B predominates (14)(15)(16)(17).…”

mentioning

confidence: 99%

A Single Early Introduction of HIV-1 Subtype B into Central America Accounts for Most Current Cases

Murillo

Véras

Prosperi

et al. 2013

J Virol

View full text Add to dashboard Cite

“…Interestingly, recombinant BG has been also identified in a previous study from Costa Rica [37]. The CRF20_BG accounts for nearly 10–20% of HIV-1 infections in Cuba and is rarely observed outside this country [40]–[44], thus supporting a direct epidemiological link between CRF20_BG-like sequences from Panama and Cuba.…”

Section: Discussionsupporting

confidence: 62%

“…This BF variant is particularly prevalent in the Brazilian city of Santos where it accounts for about 25% of infections [35], [36]. Of note, a recent study in Costa Rica also described the circulation of CRF17_BF and CRF29_BF [37], thus confirming a relative frequent influx of HIV-1 BF strains from South America into Central America.…”

Section: Discussionmentioning

confidence: 78%

Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013

et al. 2014

View full text Add to dashboard Cite

Phylogenetic studies have suggested that the HIV-1 epidemic in the Americas is mainly dominated by HIV subtype B. However, countries of South America and the Caribbean have recently reported changes in their circulating HIV-1 genetic profiles. The aim of this study was to characterize the molecular profile of the HIV-1 epidemic in Panama by the analysis of 655 polymerase gene (pol) sequences that were obtained from HIV-infected Panamanians diagnosed between 1987 and 2013. Blood samples were collected from recently infected, antiretroviral drug-naïve and treatment-experienced subjects since mid-2007 to 2013. Viral RNA from plasma was extracted and sequences of HIV protease and reverse transcriptase genes were obtained. Bootscanning and phylogenetic methods were used for HIV subtyping and to trace the putative origin of non-B subtype strains. Our results showed that HIV-1 infections in Panama are dominated by subtype B (98.9%). The remaining 1.1% is represented by a diverse collection of recombinant variants including: three URFs_BC, one CRF20_BG, and one CRF28/29_BF, in addition to one subtype F1 and one subtype C, none of which were previously reported in Panama. The non-B subtype variants detected in Panama were probably introduced from Brazil (subtype F1 and CRF28/29_BF), Cuba (CRF20_BG), Dominican Republic (URFs_BC) and India (subtype C). Panama is the geographical vertex that connects the North with South America and the Caribbean through trade and cultural relations, which may explain the observed introductions of non-B subtype HIV-1 variants from both the Caribbean and South America into this Central American country.

show abstract

“…Subtype B accounts for ≥98% of HIV infections in Costa Rica [7], El Salvador [8]–[10], Guatemala [11], Honduras [10], [12]–[16], Nicaragua [17] and Panama [18]–[20]. The most accepted model of HIV-1 subtype B origin and dispersion in the Americas suggests that the virus was first introduced from Central Africa into Haiti around 1966 (1962–1970), the virus was then disseminated from Haiti to other Caribbean islands and to the US around 1969 (1966–1972), and finally the virus migrated from US to other countries around the world [21].…”

Section: Introductionmentioning

confidence: 99%

Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades

et al. 2014

View full text Add to dashboard Cite

The Human immunodeficiency virus type-1 (HIV-1) subtype B is the most predominant clade in Central America; but information about the evolutionary history of this virus in this geographic region is scarce. In this study, we reconstructed the spatiotemporal and population dynamics of the HIV-1 subtype B epidemic in Panama. A total of 761 HIV-1 subtype B pol sequences obtained in Panama between 2004 and 2013 were combined with subtype B pol sequences from the Americas and Europe. Maximum Likelihood phylogenetic analyses revealed that HIV-1 subtype B infections in Panama derived from the dissemination of multiple founder viruses. Most Panamanian subtype B viruses (94.5%) belong to the pandemic viral strain proposed as originated in the US, whereas others (5.5%) were intermixed among non-pandemic Caribbean strains. The bulk (76.6%) of subtype B sequences from Panama grouped within 12 country-specific clades that were not detected in other Central American countries. Bayesian coalescent-based analyses suggest that most Panamanian clades probably originated between the early 1970s and the early 1980s. The root location of major Panamanian clades was traced to the most densely populated districts of Panama province. Major Panamanian clades appear to have experienced one or two periods of exponential growth of variable duration between the 1970s and the 2000s, with median growth rates from 0.2 to 0.4 year− 1. Thus, the HIV-1 subtype B epidemic in Panama is driven by the expansion of local viral strains that were introduced from the Caribbean and other American countries at an early stage of the AIDS pandemic.

show abstract

Variability in HIV-1 partial genomic sequences in Costa Rican patients: analysis with different bioinformatics tools

Cited by 7 publications

References 27 publications

A Single Early Introduction of HIV-1 Subtype B into Central America Accounts for Most Current Cases

A Single Early Introduction of HIV-1 Subtype B into Central America Accounts for Most Current Cases

Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013

Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades

Contact Info

Product

Resources

About