Variability in experimental pain studies: nuisance or opportunity?

Madden, Victoria J.; Kamerman, Peter R.; Catley, Mark J.; Bellan, Valeria; Russek, Leslie N.; Camfferman, Danny; Moseley, G. Lorimer

doi:10.1016/j.bja.2020.11.005

Cited by 15 publications

(21 citation statements)

References 21 publications

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“…The subjective individualized nature of experiencing pain, such as CeH, is created by a mix of factors unique to that person 81 . Both heterogeneity in clinical characteristics, and individual BPS characteristics such as gender, age, socio-economic status and psychosocial influences have been documented to influence the experience of pain, giving it a highly variable nature 77 , 78 , 82 . We extrapolated this knowledge to SPV, since we recently demonstrated that SPV also exists in patients with CeH 11 .…”

Section: Discussionmentioning

confidence: 99%

Spinal postural variability relates to biopsychosocial variables in patients with cervicogenic headache

Mingels

Dankaerts

Etten

et al. 2021

Sci Rep

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Patients with cervicogenic headache (CeH) showed lower spinal postural variability (SPV). In a next step, the complex character of such SPV needs to be analysed. Therefore, variables influencing SPV need to be explored. A non-randomized repeated-measure design was applied to analyse relations between biopsychosocial variables and SPV within a CeH-group (n = 18), 29–51 years, and matched control-group (n = 18), 26–52 years. Spinal postural variability, expressed by standard deviations, was deducted from 3D-Vicon motion analysis of habitual spinal postures (degrees). Interactions between SPV and pain processing, lifestyle, psychosocial characteristics were analysed. Pain processing characteristics included symptoms of central sensitization (Central Sensitization Inventory), (extra)-cephalic pressure pain thresholds (kPa/cm2/s). Lifestyle characteristics included sleep quality (Pittsburgh Sleep Quality Index), physical activity, screen-time, sedentary-time (hours a week), position (cm) and inclination (degrees) of the laptop (= desk-setup). Psychosocial characteristics included degree of depression, anxiety and stress (Depression Anxiety Stress Scale-21), impact of headache on quality of life (Headache Impact Test-6). Spinal postural variability related significantly to intrinsic (stress, anxiety, extra-cephalic pressure pain thresholds, sleep-duration) and extrinsic (desk-setup, screen-time) variables in the CeH-group. In the control-group, SPV related significantly to extra-cephalic pressure pain thresholds. Spinal postural variability related to diverse variables in the CeH-group compared to the control-group. More research is needed into a possible causal relationship and its clinical implication.

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Section: Discussionmentioning

confidence: 99%

Spinal postural variability relates to biopsychosocial variables in patients with cervicogenic headache

Mingels

Dankaerts

Etten

et al. 2021

Sci Rep

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“…Surprisingly, none of the sociodemographic or pain-related or psychological characteristics at baseline were associated with momentary pain intensity variability. Multiple factors can influence one's pain perception, including for example nociception and other biological factors, cognitions, contexts, and mood; these factors can also vary from moment to moment 52 . As such, predictors of pain intensity variability might not be individual difference characteristics, but rather time-varying characteristics.…”

Section: Predictors Of Pain Intensity Variabilitymentioning

confidence: 99%

An Ecological Momentary Assessment Study of Pain Intensity Variability: Ascertaining Extent, Predictors, and Associations With Quality of Life, Interference and Health Care Utilization Among Individuals Living With Chronic Low Back Pain

Pagé

Gauvin

Sylvestre

et al. 2022

The Journal of Pain

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“…For instance, Coghill et al showed that the anterior cingulate cortex (ACC), primary sensory cortex (SI) and prefrontal cortex (PFC) exhibited more robust activity in response to a fixed stimulus in highly sensitive compared to less sensitive individuals [8,9]. Interestingly, not only different people perceive the same stimulus differently, but there is also a significant within-subject variability, with the most profound example referring to the same stimulus being rated as painful or not within the same session, depending on the trial [36].…”

Section: Fixed Stimulus Intensitymentioning

confidence: 99%

“…Calibration, or re-calibration can have an advantage over fixed intensities in studies with multiple observations (e.g., longitudinal), as significant intra-individual differences exist when pain is assessed over days or weeks [40] or even within minutes [36]. Similarly, the effect of inter-individual factors that modulate pain perception is reduced in such an approach.…”

Section: Individual Stimulus Intensitymentioning

confidence: 99%

To Calibrate or not to Calibrate? A Methodological Dilemma in Experimental Pain Research

Adamczyk¹,

Szikszay²,

Nahman‐Averbuch³

et al. 2022

The Journal of Pain

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Variability in experimental pain studies: nuisance or opportunity?

Cited by 15 publications

References 21 publications

Spinal postural variability relates to biopsychosocial variables in patients with cervicogenic headache

Spinal postural variability relates to biopsychosocial variables in patients with cervicogenic headache

An Ecological Momentary Assessment Study of Pain Intensity Variability: Ascertaining Extent, Predictors, and Associations With Quality of Life, Interference and Health Care Utilization Among Individuals Living With Chronic Low Back Pain

To Calibrate or not to Calibrate? A Methodological Dilemma in Experimental Pain Research

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