Variability in cerebral blood flow velocity at rest and during mental stress in healthy individuals: Associations with cardiovascular parameters and cognitive performance

Montoro, Casandra I.; Duschek, Stefan; Paso, Gustavo A. Reyes del

doi:10.1016/j.biopsycho.2018.04.005

Cited by 13 publications

(17 citation statements)

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“…This study, for the first time, characterized mean beat-to-beat CBFV variability in the MCA and ACA during resting state in FMS, and its linkage with emotional, clinical and functional factors. Frequency domain analysis revealed a spectral profile with four main variability components, similar to those previously observed in healthy individuals: a first VLF component with a highest amplitude at 0.0024 Hz, a second VLF component ranging between 0.01 and 0.025 Hz, a LF component between 0.075 and 0.11 Hz, and a HF component between 0.25 and 0.35 Hz (which had the lowest amplitude and greatest extension) [ 11 , 17 – 19 ].…”

Section: Discussionsupporting

confidence: 59%

“…CBF shows spontaneous oscillations, which may be quantified through TCD analysis of beat-to-beat CBFV variability [ 11 , 12 ]. Assessment of variability in hemodynamic variables like heart rate, blood pressure and CBF according to different time scales may provide insight into pathological mechanisms [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Assessment of variability in hemodynamic variables like heart rate, blood pressure and CBF according to different time scales may provide insight into pathological mechanisms [ 13 , 14 ]. Frequency domain analysis of resting CBFV variability in healthy individuals has revealed oscillations within specific frequency ranges, where variability in the very low frequency (VLF, < 0.04 Hz) and low frequency (LF, 0.04 to 0.15 Hz) ranges [ 11 , 15 , 16 ] showed higher spectral power than that observed in the high frequency (HF, 0.15 to 0.4 Hz) range [ 11 , 13 , 17 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, short-term CBF variability has been associated with both baroreflex [ 22 ] and endothelial nitric oxide-mediated vasodilatation, and thus improved cerebral perfusion [ 23 ]. CBF variability, when maintained within physiological limits, may therefore be cerebro-protective and a marker of positive health status, reflecting the coordinated interplay of regulatory physiological systems [ 11 , 13 ]. This is congruent with the well-known positive prognostic value of heart rate variability (HRV), and the inverse association of this parameter with various physical and psychological risk factors [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Cerebral blood flow variability in fibromyalgia syndrome: Relationships with emotional, clinical and functional variables

et al. 2018

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ObjectiveThis study analyzed variability in cerebral blood flow velocity (CBFV) and its association with emotional, clinical and functional variables and medication use in fibromyalgia syndrome (FMS).MethodsUsing transcranial Doppler sonography, CBFV were bilaterally recorded in the anterior (ACA) and middle (MCA) cerebral arteries of 44 FMS patients and 31 healthy individuals during a 5-min resting period. Participants also completed questionnaires assessing pain, fatigue, insomnia, anxiety, depression and health-related quality of life (HRQoL).ResultsFast Fourier transformation revealed a spectral profile with four components: (1) a first very low frequency (VLF) component with the highest amplitude at 0.0024 Hz; (2) a second VLF component around 0.01-to-0.025 Hz; (3) a low frequency (LF) component from 0.075-to-0.11 Hz; and (4) a high frequency (HF) component with the lowest amplitude from 0.25-to-0.35 Hz. Compared to controls, FMS patients exhibited lower LF and HF CBFV variability in the MCAs (p < .005) and right ACA (p = .03), but higher variability at the first right MCA (p = .04) and left ACA (p = .005) VLF components. Emotional, clinical and functional variables were inversely related to LF and HF CBFV variability (r≥-.24, p≤.05). However, associations for the first VLF component were positive (r≥.28, p≤.05). While patients´ medication use was associated with lower CBFV variability, comorbid depression and anxiety disorders were unrelated to variability.ConclusionsLower CBFV variability in the LF and HF ranges were observed in FMS, suggesting impaired coordination of cerebral regulatory systems. CBFV variability was differentially associated with clinical variables as a function of time-scale, with short-term variability being related to better clinical outcomes. CBFV variability analysis may be a promising tool to characterize FMS pathology and it impact on facets of HRQoL.

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Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cerebral blood flow variability in fibromyalgia syndrome: Relationships with emotional, clinical and functional variables

et al. 2018

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“…This, however, contrasts with the common assumption that cerebral autoregulation keeps brain perfusion constant by buffering changes in systemic blood pressure (Folino, ). In order to stabilize blood flow, cerebral resistance vessels constrict during increases, and dilate during reductions, in blood pressure (Montoro, Duschek, & Reyes del Paso, ; Paulson, ). As such, autoregulation ensures virtual independence of cerebral blood flow from systemic blood pressure in a large blood pressure range (Folino, ).…”

Section: Discussionmentioning

confidence: 99%

Cerebral blood flow modulations during antisaccade preparation in chronic hypotension

et al. 2018

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In addition to symptoms including fatigue, dizziness, reduced drive, or mood disturbance, individuals with chronic low blood pressure (hypotension) frequently report cognitive complaints. While attentional deficits have been empirically confirmed, it is still unknown whether the impairments also encompass executive functions. This study investigated cerebral blood flow modulations in hypotension during a precued antisaccade/prosaccade task requiring the executive function of proactive inhibition in addition to preparatory attention. Using functional transcranial Doppler sonography, bilateral blood flow velocities in the middle cerebral arteries (MCA) were recorded in 39 hypotensive and 40 normotensive participants. In the task, a stimulus appeared left or right of a fixation point 5 s after a cuing stimulus; subjects had to move their gaze to the mirror image position of the stimulus (antisaccade) or toward it (prosaccade control condition). Video‐based eye tracking was used for ocular recording. A right dominant MCA blood flow increase arose during task preparation, which was smaller in hypotensive than normotensive participants. In addition, hypotensive participants exhibited lower peak velocity of the saccadic response. The extent of the reductions in blood flow and task performance in hypotension did not differ between antisaccade and prosaccade conditions. The smaller MCA flow increase may reflect reduced activity in the dorsolateral prefrontal and inferior parietal cortices during proactive inhibition and preparatory attention in hypotension. Given that group differences in blood flow and performance arose independent of task complexity and executive function load, hypotension may be characterized by basic attentional impairments rather than particular executive function deficits.

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Possible effects of short rest after lunch on hemodynamics in the afternoon

et al. 2021

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Variability in cerebral blood flow velocity at rest and during mental stress in healthy individuals: Associations with cardiovascular parameters and cognitive performance

Cited by 13 publications

References 68 publications

Cerebral blood flow variability in fibromyalgia syndrome: Relationships with emotional, clinical and functional variables

Cerebral blood flow variability in fibromyalgia syndrome: Relationships with emotional, clinical and functional variables

Cerebral blood flow modulations during antisaccade preparation in chronic hypotension

Possible effects of short rest after lunch on hemodynamics in the afternoon

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