“… | GLP1-RA | SGLT2i | Plain language summary |
Glycaemic outcomes | GRADE EVIDENCE C | GRADE EVIDENCE B |
Biomarker | N (observational) | N (RCT) | N (Meta-analysis and pooled RCT) | N (observational) | N (RCT) | N (Meta-analysis and pooled RCT) |
Glycaemia Biomarkers | 18 37 – 41 , 45 , 47 , 48 , 54 , 55 , 61 , 62 , 140 – 145 | 11 32 , 44 , 46 , 50 , 56 , 59 , 63 , 146 – 149 | 1 53 | 4 24 , 150 – 152 | 2 27 , 32 | 3 15 , 25 , 26 | Greater glycaemic response for both SGLT2i and GLP1-RA is seen in individuals with higher baseline HbA1c, No studies are available to comparing the relative efficacy of SGLT2i to GLP1-RA at different baseline HbA1c levels. |
Renal Function | 6 39 , 40 , 45 , 54 , 62 , 142 | 4 32 , 44 ... |
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