Varenicline versus placebo for waterpipe smoking cessation: a double‐blind randomized controlled trial

Dogar, Omara; Zahid, Raana; Mansoor, Sana; Kanaan, Mona; Ahluwalia, Jasjit S.; Jawad, Mohammed; Siddiqi, Kamran

doi:10.1111/add.14430

Cited by 12 publications

(5 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, we offered behavioral support to all participants (28). Upon receipt of the recruitment, researchers contact participants to schedule a face-to-face individual informal meeting, which aims to enhance the awareness of the dangers and benefits of smoking cessation, determine a quit date, explain common withdrawal symptoms and advice appropriate methods for relief.…”

Section: Procedures and Treatmentmentioning

confidence: 99%

Effects of varenicline on the serum levels of olanzapine in male patients with Schizophrenia: a randomized controlled trial

Deng¹,

Liu²,

Ni³

et al. 2023

Front. Psychiatry

View full text Add to dashboard Cite

BackgroundSmoking in patients with Schizophrenia is more common than in the general population. Varenicline, a partial agonist at α4β2 nicotinic acetylcholine receptors, is an effective smoking cessation pharmacotherapy in patients with Schizophrenia. However, its effects on the serum levels of antipsychotics in Schizophrenia are understudied. This study investigated the impact of smoking cessation with varenicline on the serum concentration of olanzapine in patients with Schizophrenia.MethodsAdult smokers with Schizophrenia were enrolled in a 12-week course of varenicline and placebo for smoking cessation. The serum concentration of olanzapine was measured at baseline and weeks 1, 2, 4, 8, and 12. Data were analyzed with the generalized additive mixed model.ResultsDuring the 12-week study, the results indicated that olanzapine concentrations increased nonlinearly in the varenicline and placebo groups. Threshold effect analysis suggested that the olanzapine concentrations increased over time until the turning point (week 4). However, there was no significant difference between the two treatment groups.ConclusionVarenicline showed safety and efficacy in smoking cessation in people with Schizophrenia.

show abstract

Section: Procedures and Treatmentmentioning

confidence: 99%

Effects of varenicline on the serum levels of olanzapine in male patients with Schizophrenia: a randomized controlled trial

Deng¹,

Liu²,

Ni³

et al. 2023

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…Waterpipe smoking cessation rates were higher in the intervention groups in all three studies. In addition, one double-blind randomised controlled study conducted by DOGAR et al [59] tested the efficacy of varenicline in achieving abstinence from all tobacco use among waterpipe smokers. This study included two parallel groups with a total number of 510 waterpipe smokers randomised for either varenicline or placebo who were followed for a period of 25 weeks post-randomisation.…”

Section: Addiction and Smoking Cessationmentioning

confidence: 99%

Waterpipe smoking: a review of pulmonary and health effects

et al. 2021

View full text Add to dashboard Cite

Waterpipe smoking is an old form of tobacco smoking, originating in Persia and the Middle East. The popularity of the waterpipe is increasing worldwide, particularly among young adults, and there are widespread misconceptions regarding its negative health effects. The inhaled smoke of the waterpipe contain several toxic and hazardous materials including nicotine, tar, polyaromatic hydrocarbons and heavy metals, all of which are proven to be related to lung diseases and cancer. Regular waterpipe smoking is associated with respiratory symptoms, a decrease in pulmonary function and increased risk for lung disease such as COPD. Additional negative health effects include increased risk for arterial stiffness, ischaemic heart disease and several cancer types including lung cancer. This review summarises the negative health effects of waterpipe smoking, with emphasis on cardiorespiratory complications. Increased awareness and knowledge amongst healthcare professionals will hopefully help identify waterpipe smokers and promote patient education. Applying World Health Organization (WHO) regulations will provide a synergistic effect in reducing waterpipe use and associated disease.

show abstract

“…У дослідженні О. Dogar та співавт. не було показано достовірної різниці щодо відмови від кальяну в групах варенікліну, який широко застосовують для лікування тютюнопаління (12 із 253; 4,7 %), та плацебо (11 із 257; 4,3 %) (ВР 1,11; 95% ДІ 0,50-2,47; Р = 0,80) [62].…”

Section: припинення паління кальянуunclassified

Вредное Влияние Курения Кальяна На Сердечно-Сосудистую Систему

Krushynska

Lyzohub

2021

View full text Add to dashboard Cite

Шкідливий вплив паління кальяну на серцево-судинну систему Резюме. Паління кальяну є відносно новою, але актуальною проблемою медицини, оскільки в Україні, як і в усьому світі, відзначається катастрофічне зростання його вживання. У структурі тютюнопаління, що залишається основним модифікованим фактором серцево-судинного ризику, останніми роками відбулися зміни зі зростанням питомої частки альтернативних тютюнових продуктів, серед яких кальян посідає друге місце. Споживачі сприймають кальян як вид соціальної активності та спосіб цікавого проведення часу й недооцінюють його шкоду для здоров'я та здатність викликати залежність. А суспільство загалом толерантніше ставиться до використання альтернативних тютюнових продуктів, аніж традиційних цигарок, у тому числі молоддю. На сьогодні є численні дані щодо зв'язку паління кальяну з розвитком артеріальної гіпертензії, ішемічної хвороби серця, інфаркту міокарда, серцевої недостатності та смертністю від цих причин. Метою огляду є оцінка факторів, які сприяють поширенню використання кальяну, його ефектів на серцево-судинну систему та можливостей припинення паління.

show abstract

Varenicline versus placebo for waterpipe smoking cessation: a double‐blind randomized controlled trial

Abstract: Varenicline was not more effective than placebo in aiding cessation of tobacco use in long-term daily waterpipe smokers.

Cited by 12 publications

References 48 publications

Effects of varenicline on the serum levels of olanzapine in male patients with Schizophrenia: a randomized controlled trial

Effects of varenicline on the serum levels of olanzapine in male patients with Schizophrenia: a randomized controlled trial

Waterpipe smoking: a review of pulmonary and health effects

Вредное Влияние Курения Кальяна На Сердечно-Сосудистую Систему

Contact Info

Product

Resources

About