Vardenafil reverses erectile dysfunction induced by paroxetine in rats

Angulo, Javier; Bischoff, Erwin; Gabancho, Sonia; Cuevas, Pedro; Tejada, Iñigo Sáenz de

doi:10.1038/sj.ijir.3900950

Cited by 27 publications

(22 citation statements)

References 15 publications

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“…Additionally, SSRI-induced erectile dysfunction was measured using intracavernous pressure assessments. Phosphodiesterase 5 inhibitor (PDE-5) inhibitors such as vardenafil and DA-8159 have been shown to reverse SSRI-induced decreases in intracavernous pressure (Ahn et al 2005;Angulo et al 2003). These preclinical effects are consistent with the observed clinical improvements in sexual function when sildenafil is combined with SSRIs (Nurnberg 2001;.…”

Section: Discussionsupporting

confidence: 58%

A novel approach for predicting antidepressant-induced sexual dysfunction in rats

Rizzo¹,

Schechter²,

Rosenzweig‐Lipson³

2007

Psychopharmacology

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Section: Discussionsupporting

confidence: 58%

A novel approach for predicting antidepressant-induced sexual dysfunction in rats

Rizzo¹,

Schechter²,

Rosenzweig‐Lipson³

2007

Psychopharmacology

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“…This hypothesis is supported by the evidence that acute or chronic paroxetine, but not citalopram, caused ED in rats by inhibiting NO production [139]. Indeed, the inhibitory effects induced by acute paroxetine on erectile function in the rat can be prevented by inhibition of PDE5 with vardenafil [140] or by coadministration of the NOS substrate, L -arginine [141]. On the other hand, venlafaxine, a mixed inhibitor of serotonin and norepinephrine (NE) reuptake, produced ED in rats by increasing NE levels, since its inhibitory effects on erectile responses were prevented by phentolamine [141].…”

Section: Sexual Dysfunction Associated To the Use Of Antidepressantsmentioning

confidence: 83%

Pathophysiology of Erectile Dysfunction

Tejada¹,

Angulo²,

Cellek

et al. 2005

The Journal of Sexual Medicine

166

111

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Introduction Multiple regulatory systems are involved in normal erectile function. Disruption of psychological, neurological, hormonal, vascular, and cavernosal factors, individually, or in combination, can induced erectile dysfunction (ED). The contribution of neurogenic, vascular, and cavernosal factors was thoroughly reviewed by our committee, while psychological and hormonal factors contributing to ED were evaluated by other committees. Aim To provide state of the art knowledge on the physiology of ED. Methods An international consultation in collaboration with the major urology and sexual medicine associations assembled over 200 multidisciplinary experts from 60 countries into 17 committees. Committee members established specific objectives and scopes for various male and female sexual medicine topics. The recommendations concerning state-of-the-art knowledge in the respective sexual medicine topic represent the opinion of experts from five different continents developed in a process over a 2-year period. Concerning the pathophysiology of ED committee, there were seven experts from five different countries. Main Outcome Measure Expert opinion was based on the grading of evidence-based medical literature, widespread internal committee discussion, public presentation, and debate. Results The epidemiology and classification of neurogenic ED was reviewed. The evidence for the association between vascular ED and atherosclerosis/hypercholesterolemia, hypertension and diabetes was evaluated. In addition, the pathophysiological mechanisms implicated in vascular ED were defined, including: arterial remodeling, increased vasoconstriction, impaired neurogenic vasodilatation, and impaired endothelium-dependent vasodilatation. The possible mechanisms underlying the association between chronic renal failure and ED were also evaluated as well as the evidence supporting the association of ED with various classes of medications. Conclusions A better understanding of how diseases interfere with the physiological mechanisms that regulate penile erection has been achieved over the last few years, which helps establish a strategy for the prevention and treatment of ED.

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“…The significant (p < 0.05) increase in ML and IL, an indicator of sexual arousability and potency, in sexually impaired rats could have resulted from reduced erectile response through the inhibition of the synthesis of nitric oxide in the penis leading to reduced carvenous stimulation in paroxetine-treated rats [27][28][29]. The capability of the extract to reverse the increase in ML and IL of sexually impaired rats indicates stimulation of sexual arousability, performance, motivation, and vigor in the rats [30].…”

Section: Discussionmentioning

confidence: 98%