Vapor‐Phase Synthesis of Molecularly Imprinted Polymers on Nanostructured Materials at Room‐Temperature

Mazzotta, Elisabetta; Giulio, Tiziano Di; Mariani, Stefano; Corsi, Martina; Malitesta, Cosimino; Barillaro, Giuseppe

doi:10.1002/smll.202302274

Cited by 5 publications

(2 citation statements)

References 116 publications

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“…Molecularly imprinted polymers (MIPs) are synthetic receptors obtained from the polymerization in a proper solvent of functional monomers and cross-linking agents around the target molecule, thus serving as a template that, once removed, leaves complementary cavities able to rebind the analyte specifically [1][2][3][4]. The principle behind the molecular imprinting technology is to mimic the molecular recognition that naturally occurs in living systems, such as enzyme-substrate and antibody-antigen complexes [5]. However, unlike their biological counterparts, MIPs possess many advantages, such as robustness and stability, as well as easy and low-cost production processes [6].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of a Molecularly Imprinted Polymer Based on a Novel Thiophene-Derivative for Electrochemical Sensing

Gagliani,

Di Giulio,

Grecchi

et al. 2024

Molecules

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An environmentally friendly and sustainable approach was adopted to produce a molecularly imprinted polymer (MIP) via electropolymerization, with remarkable electrochemical sensing properties, tested in tyrosine (tyr) detection. The 2,2′-bis(2,2′-bithiophene-5-yl)-3,3′-bithianaphtene (BT2-T4) was chosen as functional monomer and MIP electrosynthesis was carried out via cyclic voltammetry on low-volume (20 μL) screen-printed carbon electrodes (C-SPE) in ionic liquid 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ((BMIM) TFSI). An easy and rapid washing treatment allowed us to obtain the resulting MIP film, directly used for tyr electrochemical detection, carried out amperometrically. The sensor showed a linear response in the concentration range of 15–200 μM, with LOD of 1.04 µM, LOQ of 3.17 μM and good performance in selectivity, stability, and reproducibility. Tyrosine amperometric detection was also carried out in human plasma, resulting in a satisfactory recovery estimation. The work represents the first use of BT2-T4 as a functional monomer for the production of a molecularly imprinted polymer, with a green approach afforded by using a few microliters of a room temperature ionic liquid as an alternative to common organic solvents on screen-printed carbon electrodes, resulting in a valuable system that meets the green chemistry guidelines, which is today an essential criterion in both research and application field.

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Section: Introductionmentioning

confidence: 99%

Green Synthesis of a Molecularly Imprinted Polymer Based on a Novel Thiophene-Derivative for Electrochemical Sensing

Gagliani,

Di Giulio,

Grecchi

et al. 2024

Molecules

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“…8−10 Artificial receptors offer significant advantages for sensor development, including high stability, easy customization for specific analytes, and simpler, faster synthesis compared to traditional bioreceptors. 11 Iminodiacetic acid (IDA) is a metalion chelator. IDA's ability to interact with metal ions has been largely used in silica-based metal chelate affinity sorbents for chromatographic purposes.…”

Section: ■ Introductionmentioning

confidence: 99%

Reconfigurable Optical Sensor for Metal-Ion-Mediated Label-Free Recognition of Different Biomolecular Targets

Di Giulio,

Corsi,

Gagliani

et al. 2024

ACS Appl. Mater. Interfaces

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Reconfiguration of chemical sensors, intended as the capacity of the sensor to adapt to novel operational scenarios, e.g., new target analytes, is potentially game changing and would enable rapid and cost-effective reaction to dynamic changes occurring at healthcare, environmental, and industrial levels. Yet, it is still a challenge, and rare examples of sensor reconfiguration have been reported to date. Here, we report on a reconfigurable label-free optical sensor leveraging the versatile immobilization of metal ions through a chelating agent on a nanostructured porous silica (PSiO2) optical transducer for the detection of different biomolecules. First, we show the reversible grafting of different metal ions on the PSiO2 surface, namely, Ni2+, Cu2+, Zn2+, and Fe3+, which can mediate the interaction with different biomolecules and be switched under mild conditions. Then, we demonstrate reconfiguration of the sensor at two levels: 1) switching of the metal ions on the PSiO2 surface from Cu2+ to Zn2+ and testing the ability of Cu2+-functionalized and Zn2+-reconfigured devices for the sensing of the dipeptide carnosine (CAR), leveraging the well-known chelating ability of CAR toward divalent metal ions; and 2) reconfiguration of the Cu2+-functionalized PSiO2 sensor for a different target analyte, namely, the nucleotide adenosine triphosphate (ATP), switching Cu2+ with Fe3+ ions to exploit the interaction with ATP through phosphate groups. The Cu2+-functionalized and Zn2+-reconfigured sensors show effective sensing performance in CAR detection, also evaluated in tissue samples from murine brain, and so does the Fe3+-reconfigured sensor toward ATP, thus demonstrating effective reconfiguration of the sensor with the proposed surface chemistry.

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Characterization of In situ electrosynthesis of polyaniline on pencil graphite electrodes through electrochemical, spectroscopical and computational methods

Goldoni,

Thomaz,

Ottolini

et al. 2024

J Mater Sci

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This study investigates potentiodynamic synthesis of polyaniline (PANI) using pencil graphite electrodes (PGEs), aiming to elucidate deposition mechanisms under simple experimental conditions. By exploring PANI electrosynthesis through electrochemical, spectroscopic, and computational approaches, valuable insights into the physicochemical aspects of aniline polymerization are gained. The proposed synthetic method was challenged for the development of a new molecularly imprinted polymer for chloramphenicol on the surface of PGEs to obtain an innovative impedimetric sensor. The sensing platform shows a linear response in the target concentration range between 0.1 and 17.5 nM, in aqueous solutions, with a limit of detection of 0.03 nM and a limit of quantification of 0.09 nM. The results obtained suggest that the synthesis method proposed provide a way to obtain stable and electroactive polyaniline film with huge potential application.

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Vapor‐Phase Synthesis of Molecularly Imprinted Polymers on Nanostructured Materials at Room‐Temperature

Cited by 5 publications

References 116 publications

Green Synthesis of a Molecularly Imprinted Polymer Based on a Novel Thiophene-Derivative for Electrochemical Sensing

Green Synthesis of a Molecularly Imprinted Polymer Based on a Novel Thiophene-Derivative for Electrochemical Sensing

Reconfigurable Optical Sensor for Metal-Ion-Mediated Label-Free Recognition of Different Biomolecular Targets

Characterization of In situ electrosynthesis of polyaniline on pencil graphite electrodes through electrochemical, spectroscopical and computational methods

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