Vanishing twins: the frequency of spontaneous fetal reduction of a twin pregnancy

Sampson, Amanda; Crespigny, Lachlan Ch. de

doi:10.1046/j.1469-0705.1992.02020107.x

Cited by 41 publications

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“…In addition, epigenetic modifications may be also related with the human phenomenon known as “disappearance” or “vanishing twin,” which refers to the very high frequency of multiple pregnancies and the loss (or disappearance) of at least one of the twins [Landy et al, 1982]. Such observations have been confirmed by serial ultrasound [Sampson and de Crespigny, 1992; Landy and Keith, 1998] and are related to the current tendency to perform ultrasound studies at very early stages of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of acephalus/acardius monozygotic twins: New insights into an epigenetic causal hypothesis

Martı́nez-Frı́as

2009

American J of Med Genetics Pt A

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Apart from a series of 10 acephalus/acardius (Ac/Ac) cases described from a pathological point of view, and the analysis of a review of published cases, we have been unable to find any epidemiological studies on Ac/Ac. Using data from the Spanish Collaborative Study of Congenital Malformations (ECEMC), we present here what seems to be the first epidemiological analysis of a consecutive series of the Ac/Ac type of monozygotic twins (MZT). Among a total of 2,281,604 consecutive births, 11 cases of Ac/Ac MZT were detected, giving a frequency of 0.48 per 100,000 births. However, we consider the period 1980-1985 as the baseline for our data, as in this period voluntary termination of pregnancy was not possible in Spain, and the frequency of Ac/Ac MZT was 0.49 per 100,000 births. Nonetheless, this frequency should be considered as a minimal estimation. The characteristics of these Ac/Ac cases indicate that they are more frequent in males (sex ratio 2.67). In addition, gestational age in Ac/Ac cases was 2.41 and 3.12 weeks lower than in malformed and control twins, respectively. Similarly, their mothers are 4.54 and 4.68 years younger than mothers of separate malformed and control twins, respectively. To understand the biological basis behind the occurrence of MZT in the context of recent observations, we evaluate the hypothesis that the epigenetic processes involved in the early cleavage of the embryo, and in blastocyst formation during development, may be implicated in twinning.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of acephalus/acardius monozygotic twins: New insights into an epigenetic causal hypothesis

Martı́nez-Frı́as

2009

American J of Med Genetics Pt A

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“…The reason why the great majority of twin conceptuses succumb early in pregnancy is not yet known. The vanishing twin syndrome is a clinical entity (Sampson and de Crespigny, 1992). Of those twin pregnancies identified with ultrasound after 6-8 weeks' gestation, about half lead to a twin birth whereas the remainder lead to a singleton delivery.…”

Section: Discussionmentioning

confidence: 99%

No Obvious Spatial Clustering of Twin Births in Sweden between 1973 and 1990

Rydhstroem

1998

Environmental Research

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“…The frequency of multiple gestations is 3.3% to 5.4% at 8 weeks' gestation [2]. Vanishing twin syndrome occurs in 21% to 30% of multiple gestation [4]. This vanishing twin case was resulted from IVF-ET with one normal pregnancy and one gestational sac containing no embryo.…”

Section: Discussionmentioning

confidence: 93%

Two placentas in singleton pregnancy with fused umbilical cord: A case report

Park

Ryu

Cho

et al. 2012

Korean J Obstet Gynecol

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Two placentas in singleton pregnancy with fused umbilical cord which has its own placental insertion site forming 3-vessel cord at fetal end is an extremely rare case. This present case describes two placentas with fused umbilical cord with an episode of vanishing twin syndrome and there seems to be a strong relationship between these two events. A 37-year-old woman, gravid 0, para 0, visited emergency room with an episode of vaginal bleeding without pelvic cramps at 8 weeks and 5 days of gestation and repeated ultrasonic exams revealed reabsorption of vanishing twin and two separate placentas on anterior and posterior body of uterus. At 40 weeks and 4 days, the patient delivered a viable female infant weighing 3,900 g via Cesarean section and postpartum examination of the placentas and membranes confirmed two placentas with fused umbilical cord. Two placentas were almost equal in size and there were 2 cord insertions, 1 into each placenta. The cord at each of the placental disc had marginal insertion site and main placental disc cord had 2 arteries with one vein (3 vessel-cord) whereas side placental disc cord had one artery with one vein (2 vessel-cord). Several hypothesis for this two placentas with fused umbilical cord in singleton pregnancy, were proposed including placenta abnormalities after in vitro fertilization-embryo transfer procedure, succenturiate lobes and fetus in fetus, however, further evaluation is need.

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Vanishing twins: the frequency of spontaneous fetal reduction of a twin pregnancy

Cited by 41 publications

References 0 publications

Epidemiology of acephalus/acardius monozygotic twins: New insights into an epigenetic causal hypothesis

Epidemiology of acephalus/acardius monozygotic twins: New insights into an epigenetic causal hypothesis

No Obvious Spatial Clustering of Twin Births in Sweden between 1973 and 1990

Two placentas in singleton pregnancy with fused umbilical cord: A case report

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