Vanishing tumor in pregnancy

Vimal, MV; Budyal, Sweta; Kasliwal, Rajeev; Jagtap, Varsha S.; Lila, Anurag; Bandgar, Tushar; Menon, P. S. N.; Shah, Nalini

doi:10.4103/2230-8210.103038

Cited by 1 publication

(1 citation statement)

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“…Some authors speculated that the sudden growth during pregnancy may ultimately cause apoptotic phenomena once the growing stimuli are off and the fibroids are exposed to the devastating local effects that are associated to uterus involution after delivery. Interestingly, a similar pattern, i.e., rapid growth during pregnancy and subsequent disappearance has been also shown for decidualized endometriomas [ 135 , 136 , 137 ] and prolactinomas [ 138 ]. We may actually suppose that the growth of leiomyomas in early pregnancy could be a multifactorial mechanism involving steroids, local growth factors and also other placental hormones, suggesting a combination of complexity and redundancy of molecular pathways.…”

Section: Conclusion and Prospectssupporting

confidence: 56%

Human Chorionic Gonadotrophin as a Possible Mediator of Leiomyoma Growth during Pregnancy: Molecular Mechanisms

Sarais

Cermisoni

Schimberni

et al. 2017

IJMS

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Uterine fibroids are the most common gynecologic benign tumors. Studies supporting a strong pregnancy-related growth of leiomyomas generally claimed a crucial role of sex steroid hormones. However, sex steroids are unlikely the unique actors involved as estrogen and progesterone achieve a pick serum concentration in the last trimester while leiomyomas show a typical increase during the first trimester. Given the rapid exponential raise in serum human Chorionic Gonadotrophin (hCG) at the beginning of gestation, we conducted a review to assess the potential role of hCG in the striking growth of leiomyomas during initial pregnancy. Fibroid growth during initial pregnancy seems to correlate to the similar increase of serum hCG levels until 12 weeks of gestation. The presence of functional Luteinizing Hormone/human Chorionic Gonadotropin (LH/hCG) receptors was demonstrated on leiomyomas. In vitro treatment of leiomyoma cells with hCG determines an up to 500% increase in cell number after three days. Expression of cyclin E and cyclin-dependent kinase 1 was significantly increased in leiomyoma cells by hCG treatment. Moreover, upon binding to the receptor, hCG stimulates prolactin secretion in leiomyoma cells, promoting cell proliferation via the mitogen-activated protein kinase cascade. Fibroid enlargement during initial pregnancy may be regulated by serum hCG.

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