We show that complete positivity is not only sufficient but also necessary for the validity of the quantum data-processing inequality. As a consequence, the reduced dynamics of a quantum system are completely positive, even in the presence of initial correlations with its surrounding environment, if and only if such correlations do not allow any anomalous backward flow of information from the environment to the system. Our approach provides an intuitive information-theoretic framework to unify and extend a number of previous results.In the case in which we are describing global evolutions as "quantum processors" or "input-output black boxes," there is no doubt that the only operationally, physically, and mathematically well-defined way to proceed is that given by the formalism of quantum operations, in the sense of Kraus [1][2][3], i.e., completely positive (CP) linear maps. As it turns out, quantum operations can always be modeled as interactions of the input system with an environment, initially factorized from (and independent of) the input system, and discarded after the interaction took place [1][2][3][4][5]. Such a model, however, is not universally valid, but relies on an initial factorization condition.The question then naturally arises [6][7][8][9][10][11][12][13][14][15][16]: what happens when the initial factorization condition does not hold, namely, when system and environment are, already before the interaction is turned on, correlated? While this question arguably originated from practical motivations (e.g., the difficulty to experimentally enforce the initial factorization assumption), it soon moved to a more fundamental level, in an attempt to challenge the very physical arguments often put forth to promote CP dynamics as the only "physically reasonable" reduced dynamics. (On this point see, e.g., Refs. [1, 2], but also Section 8.2.4 of [3]). As one would expect, by allowing the input system and its environment to start in a correlated state, it is possible that the reduced dynamics of the system are not CP anymore. The possibility of exploring phenomena outside the CP framework attracted considerable interest [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23], in particular in connection with the possibility of circumventing thermodynamic or information-theoretic tenet like, e.g., the second law of thermodynamics (by anomalous heat flow [17,18]) or the data-processing inequality (by anomalous increase of distinguishability [20], by entanglement revivals via local operations [9,[21][22][23], or by violating the no-cloning theorem [19]). In the language of the theory of open quantum systems, all such violations are interpreted as signatures of the fact that the underlying global evolution is non-divisible [20][21][22][23][24], i.e., it cannot be decomposed into a chain of CP maps across successive time intervals. The quantum system Q, initially entangled with a reference quantum system R, locally interacts with a quantum environment E, initially factorized from both Q and R, while the ...