Vanin 1: Its Physiological Function and Role in Diseases

Bartucci, Roberta; Salvati, Anna; Olinga, Peter; Boersma, Ykelien L.

doi:10.3390/ijms20163891

Cited by 80 publications

(69 citation statements)

References 92 publications

(136 reference statements)

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“…Three single‐nucleotide polymorphisms were found to be associated with vanin‐1 transcript abundance in the colon. All in all, these findings suggest that vanin‐1 could pose as a therapeutic target or fecal biomarker in IBD (Bartucci et al, ).…”

Section: B5 In Other Diseasesmentioning

confidence: 90%

“…Similarly, medical knowledge in Egypt had a remarkable reputation, and many rheumatologic conditions have been identified in ancient Egyptian materials (Gheita & Eesa, ). Vanin is now considered a key player in the development and continuation of diseases, in both animal models and humans (Bartucci et al, ). Vanin‐1 regulates and accelerates chondrogenesis of undifferentiated mesenchymal cells and plays a central part.…”

Section: B5 In Rheumatologymentioning

confidence: 99%

“…Vanin‐3 has a pivotal role in modulating cartilage erosion and pathology and forms a possible link with metabolic disease (Fosang & Sutton, ). In spite of the established vanin's pantetheinase activity in different organs, a potential role as a signaling protein is emerging (Bartucci et al, ).…”

Section: B5 In Rheumatologymentioning

confidence: 99%

“…Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts (Wiederholt et al, ), and together with the high wound healing rates and effect on fibrosis of DEX (Ulger et al, ), new insight on a promising role in the treatment of SSc is provided. The vanin‐1 pathway, involved in VB5 generation, has a proinflammatory effect in many conditions including SSc (Bartucci et al, ; Kavian et al, ). Consequently, increased serum levels of vanin and pantothenic acid were found in SSc patients particularly those with dcSSc and pulmonary artery hypertension, proposing a significant role for vanin‐1 inhibition in SSc treatment (Barsotti et al, ).…”

Section: B5 In Rheumatologymentioning

confidence: 99%

“…Indeed, its physiological role seems strictly related to CoA metabolism, lipid metabolism, and energy production. Vanin's enzymatic activity was found to be of key importance in certain diseases, either for its protective effect or as a sensitizer, depending on the diseased organ (Bartucci, Salvati, Olinga, & Boersma, ). The proinflammatory role of vanin‐1, with its pantetheinase activity as a major regulator of intestinal inflammation, has also been pointed to (Martin et al, ).…”

Section: Introductionmentioning

confidence: 99%

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The potential role of B5: A stitch in time and switch in cytokine

Gheita

Kenawy

2019

Phytotherapy Research

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The wound healing process is a multifaceted sequence of activities associated with tissue restoration. Novel approaches for the perfection of wound healing have been determined as a stitch in time saves nine. Dysregulation of the immune response is a key element in the pathogenesis of rheumatic diseases and serves as a potential target for novel therapeutic strategies. Vitamin B5 (VB5), also known as pantothenate or "anti-stress vitamin," is the precursor of coenzyme A, which is essential in every micro-organism. Many pantothenic acid amides acquire persuasive antimicrobial activity. Pantothenic acid improves surgical wounds healing with moisturizing and skin barrier enhancing potential. Its deficiency leads to reduced cortisol production, increased arthritic pain, myalgia, fatigue, headache, depression, insomnia, and widespread "proinflammatory" effects on the immune-system. VB5 triggers immune cells to produce cytokines and is multifunctional. The paradoxical effect of VB5 on the switch of anti-inflammatory and proinflammatory cytokines has been revealed. This review aims to present the long research journey of B5 as it is becoming a forerunner in the healing of wounds and in enhancing the immune function, thus providing potentially important therapeutic implications. As its role in healing a wound stitch is promising, amending the immune system damage too is a hopeful target. KEYWORDSimmune system, pantothenic acid, rheumatic diseases, surgery, vitamin B5, wounds 2004;Pitari et al., 2000). Vanin-1 is highly expressed at gene and protein level in many organs, such as the liver, intestine, and kidney.Its major function is related to its pantetheinase activity; vanin-1 breaks down pantetheine in cysteamine and pantothenic acid, a

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Section: B5 In Other Diseasesmentioning

confidence: 90%

Section: B5 In Rheumatologymentioning

confidence: 99%

Section: B5 In Rheumatologymentioning

confidence: 99%

Section: B5 In Rheumatologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The potential role of B5: A stitch in time and switch in cytokine

Gheita

Kenawy

2019

Phytotherapy Research

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Machine learning‐driven blood transcriptome‐based discovery of SARS‐CoV‐2 specific severity biomarkers

Krishnamoorthy

Raj

Kumar

2023

Journal of Medical Virology

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The Coronavirus disease 2019 (COVID-19) pandemic, caused by rapidly evolving variants of severe acute respiratory syndrome coronavirus (SARS-CoV-2), continues to be a global health threat. SARS-CoV-2 infection symptoms often intersect with other nonsevere respiratory infections, making early diagnosis challenging. There is an urgent need for early diagnostic and prognostic biomarkers to predict severity and reduce mortality when a sudden outbreak occurs. This study implemented a novel approach of integrating bioinformatics and machine learning algorithms over publicly available clinical COVID-19 transcriptome data sets. The robust 7-gene biomarker identified through this analysis can not only discriminate SARS-CoV-2 associated acute respiratory illness (ARI) from other types of ARIs but also can discriminate severe COVID-19 patients from nonsevere COVID-19 patients. Validation of the 7-gene biomarker in an independent blood transcriptome data set of longitudinal analysis of COVID-19 patients across various stages of the disease showed that the dysregulation of the identified biomarkers during severe disease is restored during recovery, showing their prognostic potential. The blood biomarkers identified in this study can serve as potential diagnostic candidates and help reduce COVID-19-associated mortality.

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Proteomic insight into the interaction of Paenibacillus larvae with honey bee larvae before capping collected from an American foulbrood outbreak: Pathogen proteins within the host, lysis signatures and interaction markers

et al. 2022

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American foulbrood (AFB) is a devastating disease of honey bees. There remains a gap in the understanding of the interactions between the causative agent and host, so we used shotgun proteomics to gain new insights. Nano-LC-MS/MS analysis preceded visual description and Paenibacillus larvae identification in the same individual sample. A further critical part of our methodology was that larvae before capping were used as the model stage. The identification of the virulence factors SplA, PlCBP49, enolase, and DnaK in all P. larvae-positive samples was consistent with previous studies. Furthermore, the results were consistent with the array of virulence factors identified in an in vitro study of P. larvae exoprotein fractions. Although an S-layer protein and a putative bacteriocin were highlighted as important, the microbial collagenase ColA and InhA were not found in our samples. The most important virulence factor identified was isoform of neutral metalloproteinase (UniProt: V9WB82), a major protein marker responsible for the shift in the PCA biplot. This protein is associated with larval decay and together with other virulence factors (bacteriocin) can play a key role in protection against secondary invaders. Overall, this study provides new knowledge on host-pathogen interactions and a new methodical approach to study the disease.

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Vanin 1: Its Physiological Function and Role in Diseases

Cited by 80 publications

References 92 publications

The potential role of B5: A stitch in time and switch in cytokine

The potential role of B5: A stitch in time and switch in cytokine

Machine learning‐driven blood transcriptome‐based discovery of SARS‐CoV‐2 specific severity biomarkers

Proteomic insight into the interaction of Paenibacillus larvae with honey bee larvae before capping collected from an American foulbrood outbreak: Pathogen proteins within the host, lysis signatures and interaction markers

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