Vanilloid-like agents inhibit aggregation of human platelets

Almaghrabi, Safa; Geraghty, Dominic P.; Ahuja, Kiran; Adams, Murray J.

doi:10.1016/j.thromres.2014.05.038

Cited by 10 publications

(17 citation statements)

References 23 publications

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“…To the best of our knowledge this is the first study to investigate the role of TRPV1 channels, as well as CB1 and CB2 receptors, on the inhibition of platelet aggregation produced by vanilloids and endovanilloids. Aggregation was induced using three platelet agonists, collagen, AA and ADP, in combination with the presence of vanilloids and/or endovanilloids that have been shown to inhibit aggregation in the authors' previous study . The vanilloids, endovanilloids and receptor antagonists used in this study had no direct effect on platelet count.…”

Section: Discussionmentioning

confidence: 74%

“…We have previously shown that OLDA and NADA inhibited aggregation induced by collagen, while CAP and NADA suppressed AA‐induced aggregation . Moreover, CAP as well as the endovanilloid, OLDA, inhibit ADP‐induced in vitro platelet aggregation, but this effect appeared to be independent of TRPV1 channel .…”

Section: Discussionmentioning

confidence: 90%

“…Agents that suppress platelet aggregation may therefore be beneficial in the prevention and treatment of cardiovascular diseases (CVD). The active principles of spices such as capsaicin (CAP), from hot chili peppers, are reported to affect in vitro platelet aggregation …”

Section: Introductionmentioning

confidence: 99%

“…Studies have demonstrated variable effects of CAP on platelet function, including both inhibition and enhancement of aggregation . Recently, we demonstrated that CAP as well as OLDA and NADA, inhibit adenosine diphosphate (ADP)‐induced in vitro platelet aggregation through a TRPV1‐independent mechanism . OLDA and NADA also suppressed collagen‐induced aggregation, while CAP and NADA inhibited aggregation induced by arachidonic acid (AA) .…”

Section: Introductionmentioning

confidence: 99%

“…OLDA and NADA also suppressed collagen‐induced aggregation, while CAP and NADA inhibited aggregation induced by arachidonic acid (AA) . Although vanilloid‐like agents have been shown to affect platelet aggregation, the mechanism(s) are not well understood, and unlikely to be due to a direct toxic effect on platelets …”

Section: Introductionmentioning

confidence: 99%

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Inhibition of platelet aggregation by vanilloid‐like agents is not mediated by transient receptor potential vanilloid‐1 channels or cannabinoid receptors

Almaghrabi

Geraghty

Ahuja

et al. 2016

Clin Exp Pharma Physio

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Vanilloid-like agents, including capsaicin, N-arachidonoyl-dopamine and N-oleoyldopamine inhibit platelet aggregation, however little is known about the precise mechanism(s) of action. The authors have previously shown that blocking of the capsaicin receptor, transient receptor potential vanilloid-1 (TRPV1), does not interfere with capsaicin action during adenosine diphosphate (ADP)-induced aggregation. This research is extended to investigate the effect of these vanilloid-like-agents on platelet count, and to test whether the effect of these agents is mediated through TRPV1 and/or cannabinoid (CB1 and CB2) receptors in the presence of other agonists, including collagen and arachidonic acid. Incubation of platelets with each of the individual vanilloids, or with receptor antagonists of TRPV1 (SB452533), CB1 (AM251) and CB2 (AM630), for up to 2 h did not significantly affect the platelet count. Similarly, the effect of individual vanilloids on the inhibition of platelet aggregation was not significantly different in the presence of receptor agonists compared to control, irrespective of the agonist used, suggesting that the inhibitory effect of vanilloids on platelet aggregation is independent of TRPV1, CB1 and CB2 receptors. Further research on the antiplatelet activity of vanilloids should focus on mechanisms other than those associated with vanilloid receptors.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Inhibition of platelet aggregation by vanilloid‐like agents is not mediated by transient receptor potential vanilloid‐1 channels or cannabinoid receptors

Almaghrabi

Geraghty

Ahuja

et al. 2016

Clin Exp Pharma Physio

View full text Add to dashboard Cite

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Bioactive Oleic Derivatives of Dopamine: A Review of the Therapeutic Potential

Pokorski

Zając

2018

Advances in Experimental Medicine and Biology

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Lipid derivatives of dopamine are a novel class of compounds raising a research interest due to the potential of their being a vehicle for dopamine delivery to the brain. The aim of the present paper is to review the main features of the two most prominent bioactive members of this family, namely, N-oleoyl-dopamine (OLDA) and 3'-O-methyl-N-oleoyl-dopamine (OMe-OLDA), with emphasis on the possible therapeutic properties.

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