Vanillin: a review on the therapeutic prospects of a popular flavouring molecule

Arya, Sagar S.; Rookes, James; Cahill, David M.; Lenka, Sangram K.

doi:10.1007/s13596-020-00531-w

Cited by 133 publications

(75 citation statements)

References 88 publications

(60 reference statements)

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“…The levels of cyanidin-3- O -glucoside showed no clear response to the irrigation treatment. Similar results showing higher amounts of most primary anthocyanins following RDI treatments were shown in other works on cabernet sauvignon [ 61 , 62 , 63 ]. One of these works [ 60 ] also showed that cyanidin-3- O -glucoside is indifferent to RDI treatments, and the dose did not accumulate following water deficits of higher levels.…”

Section: Resultssupporting

confidence: 90%

“…Catechin and epicatechin play a pivotal role in the maintenance of the body weight [ 66 ], and serve as neuroprotective [ 65 ] and cardioprotective agents [ 62 ]. Vanillin and vanillic acid provide a specific flavor and fragrance to wine, and have neuroprotective, anticarcinogenic, and antioxidant properties [ 63 ]. Meanwhile, quercetin is utilized as an antioxidant and nutraceutical compound [ 67 ], and is well known for its anti-inflammatory [ 68 ], cardioprotective [ 69 ], immunoprotective [ 68 ], anticancer [ 70 , 71 ], and antidiabetic [ 72 ] properties.…”

Section: Resultsmentioning

confidence: 99%

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The Effect of Irrigation-Initiation Timing on the Phenolic Composition and Overall Quality of Cabernet Sauvignon Wines Grown in a Semi-Arid Climate

Drori

Munitz

Pinkus

et al. 2022

Foods

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In semi-arid areas, vineyards grown for winemaking are usually mildly irrigated by drip irrigation systems in a manner maintaining drought stress. This practice ensures the proper development of vegetative and reproductive organs on the one hand, and on the other, the development of high-quality grapes which can be hampered by overly abundant water application. In previous work, we have developed and demonstrated an irrigation model suitable for high-quality grape production in semi-arid areas. Here, we tackle the question of proper irrigation initiation dates—should one wait for vines to develop drought stress before the initiation of irrigation, or rather commence irrigation earlier? Our results show that vines which undergo initial irrigation late in the growing season tend to develop a lower midday stem water potential even after irrigation initiation. In addition, these vines tend to produce a lower number of bunches per vine and smaller berry size, leading to lower yields. The wine produced from the late-irrigated treatments had a higher phenolic content, primarily due to higher levels of catechin and epicatechin. Their levels increased as irrigation initiation dates were delayed, while caffeic acid levels showed an opposite trend. Late irrigation also led to higher color intensities compared to those of irrigation at earlier stages, due to higher levels of most anthocyanins. Finally, we show that the overall wine sensory score, representing its overall quality, was approximately five points higher for wines made from delayed irrigation treatments compared to wines made from early season irrigation treatments.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

The Effect of Irrigation-Initiation Timing on the Phenolic Composition and Overall Quality of Cabernet Sauvignon Wines Grown in a Semi-Arid Climate

Drori

Munitz

Pinkus

et al. 2022

Foods

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“…β-Sitosterol has been reported to show high activity against chloroquine-sensitive (3D7) strains, with an IC 50 value of 5.51 µM [42]. Vanillin has been shown to exhibit anticancer, antiangiogenic, analgesic, anti-inflammatory, antifungal, antibacterial and antiviral effects [43,44]. Protocatechuic acid is well known to exhibit antioxidant, anti-inflammatory, antihyperglycemic, antibacterial, anticancer, and antispasmodic properties [45].…”

Section: Discussionmentioning

confidence: 99%

In vivo assessment of the antimalarial activity and acute oral toxicity of an ethanolic seed extract of Spondias pinnata (L.f.) Kurz

Chaniad

Phuwajaroanpong

Plirat

et al. 2022

BMC Complement Med Ther

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Background In response to the persistent problem of malaria resistance, medicinal herbal plants can be used as a source of potential novel antimalarial agents. Therefore, the aim of this study was to evaluate the in vivo antimalarial activity and toxicity of an ethanolic seed extract of Spondias pinnata (L.f.) Kurz (S. pinnata). Methods Qualitative phytochemical screening of the extract was performed using standard procedures, and the constituents were determined by gas chromatography–mass spectrometry (GC–MS). The in vivo antimalarial activity was assessed against the Plasmodium berghei ANKA strain in mice based on 4-day suppressive, curative and prophylactic tests. In addition, the acute toxicity of the extract was evaluated after oral administration of a single dose of 2,000 mg/kg body weight. Results Phytochemical screening tests on the ethanolic S. pinnata seed extract revealed the presence of terpenoids, tannins, and coumarins. GC–MS analysis of the extract led to the identification of twenty-nine phytochemical compounds, including oleic acid amide, β-sitosterol, linoleic acid, oleic acid, protocatechuic acid, syringic acid and gallic acid. The results of the 4-day suppressive test revealed that mice treated with 250, 500, 600 and 800 mg/kg doses of the ethanolic S. pinnata seed extract showed significant parasitemia suppression in a dose-dependent manner, with 22.94, 49.01, 60.67 and 66.82% suppression, respectively, compared to that of the negative control group. All the doses of the ethanolic seed extract significantly suppressed parasitemia (P < 0.05) during the curative activity test and prolonged the mean survival time compared to those of the negative control group. However, the ethanolic seed extract displayed lower curative and prophylactic activities than the standard drug artesunate. In addition, the ethanolic seed extract showed no signs of toxicity in mice at a dose of 2,000 mg/kg body weight. Conclusion The S. pinnata seed extract contains various phytochemical compounds with important medicinal properties. The extract showed a significant suppression of parasitemia in a dose-dependent manner, prolonged the mean survival time and exhibited significant curative and prophylactic activities. The overall results of this study demonstrated that the S. pinnata seed extract possessed promising in vivo antimalarial activity against P. berghei ANKA, with no toxicity. The findings from the present study provide scientific evidence supporting the use of S. pinnata seeds in the development of new drugs for malaria treatment. Additional studies are needed to isolate and identify the active compounds as well as to understand the mechanism of inhibition.

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“…Vanillin (4-hydroxy-3-methoxybenzaldehyde) is derived from the orchid Vanilla planifolia and used as one kind of flavor in various industries, such as ice creams and pharmaceuticals. Vanillin and its derivatives have different bioactive properties and are changing from a popular flavor to therapeutic molecules (Arya et al, 2021). It was found that vanillin could inhibit respiration of E. coli and L. innocua, increase the permeability of cell membranes, and cause more severe membrane damage after hydroxyl modification (Fitzgerald et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Vanillin Derivatives Reverse Fusobacterium nucleatum-Induced Proliferation and Migration of Colorectal Cancer Through E-Cadherin/β-Catenin Pathway

Zhou

Wang

et al. 2022

Front. Pharmacol.

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Colorectal cancer (CRC) is a common clinical malignant tumor and closely related to intestinal microbiome disorders. Especially, Fusobacterium nucleatum (F. nucleatum) is one of the most prevalent pathogens in CRC. However, its change in CRC patients of Northwest China, an area with a high incidence of gastrointestinal tumors, is unclear, and therapeutic strategies targeting F. nucleatum remain unresolved. Here, fecal samples of healthy people and CRC patients were studied using 16S rRNA sequencing to explore microbial community alterations. Additionally, vanillin derivate (IPM711 and IPM712) intervention by coculture with CRC cells and potential mechanism were investigated. Results showed that intestinal microbial homeostasis was gradually dysregulated, and the abundance of Fusobacterium was higher in CRC patients. Moreover, IPM711 and IPM712 showed better anti-F. nucleatum activity than vanillin by increasing cell membrane permeability and destroying bacterial integrity. In addition, IPM711 and IPM712 could downregulate the expression of E-cadherin and β-catenin, thus, suppressing the migration of HCT116. Collectively, IPM711 and IPM712 have both anticolorectal cancer and anti-F. nucleatum activities, providing potential natural product drug candidates for microbe-targeted strategies for the treatment of CRC.

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Vanillin: a review on the therapeutic prospects of a popular flavouring molecule

Cited by 133 publications

References 88 publications

The Effect of Irrigation-Initiation Timing on the Phenolic Composition and Overall Quality of Cabernet Sauvignon Wines Grown in a Semi-Arid Climate

The Effect of Irrigation-Initiation Timing on the Phenolic Composition and Overall Quality of Cabernet Sauvignon Wines Grown in a Semi-Arid Climate

In vivo assessment of the antimalarial activity and acute oral toxicity of an ethanolic seed extract of Spondias pinnata (L.f.) Kurz

Vanillin Derivatives Reverse Fusobacterium nucleatum-Induced Proliferation and Migration of Colorectal Cancer Through E-Cadherin/β-Catenin Pathway

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