Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/ β-Catenin Pathway in Dermal Papilla Cells

Kang, Jingoo; Choi, Youn Kyung; Koh, Young‐Sang; Hyun, Jin‐Won; Kang, Jihoon; Lee, Kwang-Sik; Lee, Chun Mong; Yoo, Eun-Sook; Kang, Hee‐Kyoung

doi:10.4062/biomolther.2019.206

Cited by 23 publications

(17 citation statements)

References 35 publications

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“…Low-level laser therapy (LLLT) also seems to improve hair regrowth in the conditions of AGA, AA, and chemotherapy-induced alopecia [ 133 ]. There are studies demonstrating the positive effects of natural bioactive compounds on AGA [ 24 , 30 , 52 , 55 , 56 , 58 , 134 , 135 , 136 , 137 , 138 ]. A recently published study demonstrates that a 5-mer peptide (GLYYF; P5) has the potential to promote hair growth when topically applied [ 139 ].…”

Section: Available and Recently Studied Therapeutics For Agamentioning

confidence: 99%

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Papukashvili

Rcheulishvili

Liu

et al. 2021

Cells

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Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for developing a feasible remedy for preventing and treating AGA. The Wnt/β-catenin signaling pathway is critical in hair restoration. Thus, AGA treatment via modulating this pathway is rational, although challenging. Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling. Thus, in order to stimulate the Wnt/β-catenin signaling pathway, inhibition of DKK1 is greatly demanding. Studying DKK1-targeting microRNAs (miRNAs) involved in the Wnt/β-catenin signaling pathway may lay the groundwork for the promotion of hair growth. Bearing in mind that DKK1 inhibition in the balding scalp of AGA certainly makes sense, this review sheds light on the perspectives of miRNA-mediated hair growth for treating AGA via regulating DKK1 and, eventually, modulating Wnt/β-catenin signaling. Consequently, certain miRNAs regulating the Wnt/β-catenin signaling pathway via DKK1 inhibition might represent attractive candidates for further studies focusing on promoting hair growth and AGA therapy.

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Section: Available and Recently Studied Therapeutics For Agamentioning

confidence: 99%

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Papukashvili

Rcheulishvili

Liu

et al. 2021

Cells

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“…These results demonstrated that BDB can effectively increase DPC proliferation. Cell proliferation and death are associated with changes in cell cycle-related proteins [ 27 , 34 ]. To investigate the mechanism by which BDB promotes DPC proliferation, we examined the levels of cell cycle-related proteins in DPCs.…”

Section: Resultsmentioning

confidence: 99%

“…Hair growth is positively or negatively regulated by various signaling factors. The mechanisms by which BDB promotes hair growth and proliferation of DPCs in this study are as follows: First, the Wnt/β-catenin pathway plays an important role in hair growth as well as in the regulation of proliferation of DPCs [ 22 , 27 , 36 ]. It has been reported that the Wnt/β-catenin pathways are involved in hair regeneration after wounding, prolongation of the anagen phase, and inhibition of apoptosis in DPCs [ 22 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

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5-Bromo-3,4-dihydroxybenzaldehyde Promotes Hair Growth through Activation of Wnt/β-Catenin and Autophagy Pathways and Inhibition of TGF-β Pathways in Dermal Papilla Cells

et al. 2022

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Various studies addressing the increasing problem of hair loss, using natural products with few side effects, have been conducted. 5-bromo-3,4-dihydroxybenzaldehyde (BDB) exhibited anti-inflammatory effects in mouse models of atopic dermatitis and inhibited UVB-induced oxidative stress in keratinocytes. Here, we investigated its stimulating effect and the underlying mechanism of action on hair growth using rat vibrissa follicles and dermal papilla cells (DPCs), required for the regulation of hair cycle and length. BDB increased the length of hair fibers in rat vibrissa follicles and the proliferation of DPCs, along with causing changes in the levels of cell cycle-related proteins. We investigated whether BDB could trigger anagen-activating signaling pathways, such as the Wnt/β-catenin pathway and autophagy in DPCs. BDB induces activation of the Wnt/β-catenin pathway through the phosphorylation of GSG3β and β-catenin. BDB increased the levels of autophagic vacuoles and autophagy regulatory proteins Atg7, Atg5, Atg16L, and LC3B. We also investigated whether BDB inhibits the TGF-β pathway, which promotes transition to the catagen phase. BDB inhibited the phosphorylation of Smad2 induced by TGF-β1. Thus, BDB can promote hair growth by modulating anagen signaling by activating Wnt/β-catenin and autophagy pathways and inhibiting the TGF-β pathway in DPCs.

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“…All hair follicles periodically undergo a hair cycle that consists of anagen (growth), catagen (regression) and telogen (rest) ( Ji et al, 2021 ). Many recent studies have reported that hair cycle is regulated by the interaction between mesenchymal cells and epithelial cells in hair follicles, and the proliferation of dermal papilla (DP) cells by the activation of PI3K/Akt/Wnt/β-catenin pathway may be the key factor ( Botchkarev and Kishimoto, 2003 ; Kang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase

Kim

Jang

Kim

et al. 2022

Front. Cell Dev. Biol.

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Human hair dermal papillary (DP) cells comprising mesenchymal stem cells in hair follicles contribute critically to hair growth and cycle regulation. The transition of hair follicles from telogen to anagen phase is the key to regulating hair growth, which relies heavily on the activation of DP cells. In this paper, we suggested exosomes derived from bovine colostrum (milk exosomes, Milk-exo) as a new effective non-surgical therapy for hair loss. Results showed that Milk-exo promoted the proliferation of hair DP cells and rescued dihydrotestosterone (DHT, androgen hormones)-induced arrest of follicle development. Milk-exo also induced dorsal hair re-growth in mice at the level comparable to minoxidil treatment, without associated adverse effects such as skin rashes. Our data demonstrated that Milk-exo accelerated the hair cycle transition from telogen to anagen phase by activating the Wnt/β-catenin pathway. Interestingly, Milk-exo has been found to stably retain its original properties and efficacy for hair regeneration after freeze-drying and resuspension, which is considered critical to use it as a raw material applied in different types of alopecia medicines and treatments. Overall, this study highlights a great potential of an exosome from colostrum as a therapeutic modality for hair loss.

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Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/ β-Catenin Pathway in Dermal Papilla Cells

Cited by 23 publications

References 35 publications

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

5-Bromo-3,4-dihydroxybenzaldehyde Promotes Hair Growth through Activation of Wnt/β-Catenin and Autophagy Pathways and Inhibition of TGF-β Pathways in Dermal Papilla Cells

Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase

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