Vanillic Acid Inhibits Lung Carcinogenesis by Modulates Glycoprotein Abnormalities, Membrane-Bound Enzymes, and Inflammatory Markers

Velli, Sathesh Kanna; Devaki, Thiruvengadam

doi:10.22159/ijpps.2020v12i3.36607

Cited by 5 publications

(3 citation statements)

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“…47 Vanillic acid has been shown to inhibit lung carcinogenesis by antiinflammatory and free radical scavenging mechanisms in Swiss albino mice. 48 Vanillin extracted from millet was shown to inhibits the proliferation of HT-29 cells through G0/G1 cell arrest and induction of apoptosis. 49 The bioactive metabolites in the crude herbal extracts, guided by CCA cell inhibition, were investigated using a partial least squares (PLS) regression analysis.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Anticancer Potentials and Metabolic Profiling of Benjakul, A Thai Herbal Preparation

2024

TJNPR

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A traditional Chinese multi-herbal extract was discovered to produce antioxidant and anti-aging effects. 2 Benjakul (BJK), a Thai herbal remedy, is a common treatment for inflammation and cancer in Thai traditional medicine and it is included on the National Lists of Essential Medicines. BJK comprises five medicinal plants including Piper retrofractum Vahl. (Pr), Piper sarmentosum Roxb. (Ps), Piper interuptum Opiz. (Pi), Plumbago indica L. (Pn), and Zingiber officinale Rosc. (Zo). BJK has been reported to be used as anticancer remedies in Thai traditional medicine. It has been used as the initial medication to reduce pain and manage patients' symptoms prior to the administration of other treatments. 4,5 Previous reports have indicated that the herbal remedy and its individual plant components exhibit cytotoxic effects against cancer cells 6 antiallergic 7 and anti-inflammatory effects. [7][8][9][10] In addition, isolated compounds from BJK have shown cytotoxic activity on breast cancer cells, 11 and large and small cell lung cancer cells. 12,13 It has been demonstrated that plant extracts and plant-derived compounds exhibit anticancer properties by activating the apoptotic pathway. [14][15][16][17] Some specific plant components in the BJK formulation caused cell death by apoptotic signalling. [18][19][20][21] At present, nuclear magnetic resonance (NMR) spectroscopy is increasingly being used in the fields of food science, [22][23][24] medicine and health, [25][26][27][28][29] and natural products. 30 Recently, NMR was used to analyze the Chinese herbal medicine, Sophora flavescens, and two novel chemical compounds were identified. 31 In addition, a previous study used NMR-based metabolomics to identify changes in the metabolic profile of a local cultivar of Andrographis paniculata during its growth period. 32

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Section: Resultsmentioning

confidence: 99%

Antioxidant and Anticancer Potentials and Metabolic Profiling of Benjakul, A Thai Herbal Preparation

2024

TJNPR

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“…VA also has a chemopreventive effect in rats with experimentally induced carcinogenesis (Chiang et al, 2003; Gong, Zhou, et al, 2019). Our group's recent study has demonstrated the ability of VA to prevent lung cancer (Velli & Devaki, 2020Velli et al, 2019). As a result, we are interested to investigate the anti‐proliferative, anti‐inflammatory, and abnormalities in a subcellular level enzyme discovered in Swiss albino mice.…”

Section: Introductionmentioning

confidence: 99%

Vanillic acid attenuates cell proliferation, xenobiotic enzyme activity, and the status of pulmonary mitochondrial enzymes in lung carcinoma

Velli

Jagan

Sharmila

et al. 2022

Journal of Food Biochemistry

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The purpose of the study is to determine the anti‐proliferative and mitochondrial status of benzo(a)pyrene‐induced lung cancer in Swiss albino mice, as well as the modulatory effect of vanillic acid on it. B(a)P had altered levels of lysosomal enzymes, xenobiotic‐metabolizing enzymes, cell proliferation, inflammation, and mitochondrial abnormalities, whereas treatment with VA treatment significantly reversed the aforementioned activities. According to the findings, VA greatly reduces lung carcinogenesis by restoring antioxidants and xenobiotic‐enzyme levels, consequently proving to be an anti‐proliferative and anti‐inflammatory drug against lung cancer in mice. Practical applications As we all know, lung cancer is on the rise all over the world. A recent study demonstrated that vanillic acid protects against B(a)P in experimental mice. According to the findings, VA considerably suppresses lung carcinogenesis by restoring lysosomal enzyme levels, xenobiotic‐metabolizing enzyme levels, and mitochondrial activities, effectively functioning as an anti‐proliferative and anti‐inflammatory therapy against lung cancer. According to the most recent study, vanillic acid can be used as a defensive medicine in the treatment of lung cancer.

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“…These compounds have been used in research area such as antioxidant activities and anti-inflammatory activities [14] , [15] , [16] , [17] , [18] . Even though they are less toxic compounds, they have anticancer activities in higher concentration [19] , [20] , [21] . Because of having anticancer activities based on previous studies, we would like to study whether these compounds can affect mitochondria function and P-gp function by impairing cellular energetic state.…”

Section: Introductionmentioning

confidence: 99%

Modulation of p-glycoprotein-mediated efflux pirarubicin in living multidrug-resistant K562/Dox cell lines by 4-hydroxybenzoic acid and 4-hydroxy-3-methoxybenzoic acid via impairment of the cellular energetic state

et al. 2022

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Vanillic Acid Inhibits Lung Carcinogenesis by Modulates Glycoprotein Abnormalities, Membrane-Bound Enzymes, and Inflammatory Markers

Cited by 5 publications

References 49 publications

Antioxidant and Anticancer Potentials and Metabolic Profiling of Benjakul, A Thai Herbal Preparation

Antioxidant and Anticancer Potentials and Metabolic Profiling of Benjakul, A Thai Herbal Preparation

Vanillic acid attenuates cell proliferation, xenobiotic enzyme activity, and the status of pulmonary mitochondrial enzymes in lung carcinoma

Modulation of p-glycoprotein-mediated efflux pirarubicin in living multidrug-resistant K562/Dox cell lines by 4-hydroxybenzoic acid and 4-hydroxy-3-methoxybenzoic acid via impairment of the cellular energetic state

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