Vanillic acid: A potential inhibitor of cardiac and aortic wall remodeling in l-NAME induced hypertension through upregulation of endothelial nitric oxide synthase

Kumar, Subramanian; Pichavaram, Prahalathan; Raja, Boobalan

doi:10.1016/j.etap.2014.07.011

Cited by 43 publications

(21 citation statements)

References 51 publications

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“…In addition, the treatment of animals with the fraction decreased oxidative stress as measured by serum malondialdehyde levels. These results are in line with previous studies, indicating that the antioxidant activity of phenolic compounds such as quercetin [31], vanillic acid [50], and rutin [51] are mainly responsible for the effects of these compounds on blood pressure in different models of hypertension. Recently, quercetin, one of the constituents of Fr 2 SySFV was shown to exert a reduction on blood pressure and on serum malondialdehyde levels in spontaneously hypertensive rats [52].…”

Section: Discussionsupporting

confidence: 93%

Antioxidant and Antihypertensive Effects of a Chemically Defined Fraction of Syrah Red Wine on Spontaneously Hypertensive Rats

et al. 2017

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A particularly phenolic-rich fraction extracted from red wine from the São Francisco valley (Northeastern Brazil) was chemically characterized and its hypotensive and antioxidant effects on spontaneously hypertensive rats were studied both in vitro and in vivo. The liquid-liquid pH dependent fractionation scheme afforded a fraction with high content of bioactive phenolics such as flavonols, flavonol glycosides, phenolic acids and anthocyanins, whose identities were confirmed by liquid chromatography coupled to mass spectrometry analysis. Pretreatment of spontaneously hypertensive rats with this wine fraction at doses of 50 and 100 mg/kg by gavage for 15 days was able to decrease mean arterial pressure and heart rate as well as decrease serum lipid peroxidation. The fraction at concentrations of 0.01–1000 µg/mL induced concentration-dependent relaxation of isolated rat superior mesenteric artery rings pre-contracted with phenylephrine and this effect was not attenuated by endothelium removal. Our results demonstrate it is possible for phenolic constituents of red wine that are orally bioavailable to exert in vivo hypotensive and antioxidant effects on intact endothelial function.

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Section: Discussionsupporting

confidence: 93%

Antioxidant and Antihypertensive Effects of a Chemically Defined Fraction of Syrah Red Wine on Spontaneously Hypertensive Rats

et al. 2017

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“…A similarly clean, high‐yield route to vanillin, or to vanillic acid, starting from ferulic acid would be highly desirable. Vanillic acid, for example, is a valued fragrance and flavoring agent with several further beneficial effects due to its chemopreventive, hepatoprotective and cardioprotective activity, and a global market in various application areas exceeding $200 million…”

Section: Methodsmentioning

confidence: 99%

One‐Pot, Clean Synthesis of Vanillic Acid from Ferulic Acid

et al. 2016

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“…Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a benzoic acid derivative found in plant and fruits that is being used as a preservative and antiseptic agent in cosmetic, food, and pharmaceutical industries. Vanillic acid also possess many pharmacological functions such as antihypertensive (Kumar et al 2014), antioxidant (Stanely Mainzen Prince et al 2011, and anticancer effects (Chou et al 2010). Vanillic acid has significant antioxidant activity due to the presence of the carboxyl group (Chou et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice

Turgut

Mert

Kara

et al. 2015

Pharmaceutical Biology

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Context: Morus nigra L. (Moraceae) has various uses in traditional medicine. However, the effect of M. nigra on cognitive impairment has not been investigated yet. Objective: The objective of this study is to determine the phenolic acid content and DNA damage protection potential of M. nigra leaf extract and to investigate the extract effect on cognitive impairment and oxidative stress in aging mice. Materials and methods: Phenolic acid content was determined by quantitative chromatographic analysis. DNA damage protection potential was evaluated on pBR322 plasmid DNA. Thirty-two Balb-C mice were randomly divided into four groups (control, D-galactose, D-galactose + M. nigra 50, and D-galactose + M. nigra 100). Mice were administered D-galactose (100 mg/kg, subcutaneous) and M. nigra (50 or 100 mg/kg, orally) daily for 8 weeks. Behavioral responses were evaluated with Morris water maze. Activities of antioxidant enzymes and levels of malondialdehyde (MDA) were assayed in serum, brain, and liver. Results: In extract, vanillic (632.093 mg/g) and chlorogenic acids (555.0 mg/g) were determined. The extract between 0.02 and 0.05 mg/mL effectively protected all DNA bands against the hazardous effect of UV and H 2 O 2 . Morus nigra significantly improved learning dysfunctions (p 50.01), increased memory retention (p50.01), reduced MDA levels (p50.05), and elevated SOD, GPx, and CAT activities (p50.05) compared with the D-galactose group. Discussion and conclusion: These results show that M. nigra has the potential in improving cognitive deficits in mice and that M. nigra may be useful to suppress aging, partially due to its scavenging activity of free radicals and high antioxidant capacity. ARTICLE HISTORY

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Vanillic acid: A potential inhibitor of cardiac and aortic wall remodeling in l-NAME induced hypertension through upregulation of endothelial nitric oxide synthase

Cited by 43 publications

References 51 publications

Antioxidant and Antihypertensive Effects of a Chemically Defined Fraction of Syrah Red Wine on Spontaneously Hypertensive Rats

Antioxidant and Antihypertensive Effects of a Chemically Defined Fraction of Syrah Red Wine on Spontaneously Hypertensive Rats

One‐Pot, Clean Synthesis of Vanillic Acid from Ferulic Acid

Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice

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