Vanderbilt Cooperative Study of Maternal and Infant Nutrition

McGanity, William J.

doi:10.1001/jama.1958.63000160015012

Cited by 7 publications

(1 citation statement)

References 11 publications

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“…There have been many studies of the influence of diet on the birth-weight of the infant. It appears that the latter is little influenced either by the quality of the diet (Williams and Fralin, 1942;Northrop and Piper, 1947;and Crump et al, 1959), or the protein intake (Macy et al, 1954;McGanity et al, 1958) or the caloric intake (Smith, 1962).…”

Section: Discussionmentioning

confidence: 99%

Nutrition Studies in Pregnancy

Hankin

Burden

Symonds

1964

Aust NZ J Obst Gynaeco

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Summary: The eating habits and nutrient intakes have been related to the outcome of pregnancy in a series of 174 women. The majority of the women were eating diet3 which appeared to be adequate, if not optimal, in regard to most nutrients. No relationship was found between maternal diet and the outcome of pregnancy in this series. No relationship was demonstrated between maternal nutrient intake and the birth‐weight of the baby. The intake of calcium was below most currently accepted standards.

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Section: Discussionmentioning

confidence: 99%

Nutrition Studies in Pregnancy

Hankin

Burden

Symonds

1964

Aust NZ J Obst Gynaeco

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Low ascorbic acid and increased oxidative stress in gulo(−/−) mice during development

Harrison¹,

Meredith²,

Dawes³

et al. 2010

Brain Research

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Vitamin C (ascorbic acid, AA) depletion during pre-natal and post-natal development can lead to oxidative stress in the developing brains and other organs. Such damage may lead to irreversible effects on later brain function. We studied the relationship between AA deficiency and oxidative stress during development in gulonolactone oxidase (gulo) knockout mice that are unable to synthesize their own ascorbic acid. Heterozygous gulo(+/−) mice can synthesize AA and typically have similar tissue levels to wild-type mice. Gulo(+/−) dams were mated with gulo(+/−) males to provide offspring of each possible genotype. Overall, embryonic day 20 (E20) and post-natal day 1 (P1) pups were protected against oxidative stress by sufficient AA transfer during pregnancy. On post-natal day 10 (P10) AA levels were dramatically lower in liver and cerebellum in gulo (−/−) mice and malondialdehyde (MDA) levels were significantly increased. In post-natal day 18 pups (P18) AA levels decreased further in gulo(−/−) mice and oxidative stress was observed in the accompanying elevations in MDA in liver, and F2-isoprostanes in cortex. Further, total glutathione levels were higher in gulo(−/−) mice in cortex, cerebellum and liver, indicating that a compensatory antioxidant system was activated. These data show a direct relationship between AA level and oxidative stress in the gulo(−/−) mice. They reinforce the critical role of ascorbic acid in preventing oxidative stress in the developing brain in animals that, like humans, cannot synthesize their own AA.

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