Vancomycin-resistant Corynebacterium species causing prosthetic valve endocarditis successfully treated with imipenem and ciprofloxacin

Barnass, Stella; Holland, Karen; Tabaqchali, Soad

doi:10.1016/0163-4453(91)91591-k

Cited by 12 publications

(9 citation statements)

References 29 publications

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“…There have also been reports of glycopeptide resistance in bacteria identified as Arcanobacterium haemolyticum (130), Corynebacterium spp. (28,130,134), Lactococcus spp. (130,374), Oerskovia spp.…”

Section: Other Gram-positive Bacteriamentioning

confidence: 99%

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Current perspectives on glycopeptide resistance

et al. 1995

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In the last 5 years, clinical isolates of gram-positive bacteria with intrinsic or acquired resistance to glycopeptide antibiotics have been encountered increasingly. In many of these isolates, resistance arises from an alteration of the antibiotic target site, with the terminal D-alanyl-D-alanine moiety of peptidoglycan precursors being replaced by groups that do not bind glycopeptides. Although the criteria for defining resistance have been revised frequently, the reliable detection of low-level glycopeptide resistance remains problematic and is influenced by the method chosen. Glycopeptide-resistant enterococci have emerged as a particular problem in hospitals, where in addition to sporadic cases, clusters of infections with evidence of interpatient spread have occurred. Studies using molecular typing methods have implicated colonization of patients, staff carriage, and environmental contamination in the dissemination of these bacteria. Choice of antimicrobial therapy for infections caused by glycopeptide-resistant bacteria may be complicated by resistance to other antibiotics. Severe therapeutic difficulties are being encountered among patients infected with enterococci, with some infections being untreatable with currently available antibiotics.

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Section: Other Gram-positive Bacteriamentioning

confidence: 99%

“…Endocarditis caused by a vancomycin-resistant Corynebacterium sp. has been successfully treated with imipenem and ciprofloxacin (28). CAPD peritonitis caused by Lactobacillus casei responded slowly to intraperitoneal erythromycin and oral rifampin (332).…”

Section: Infections By Other Glycopeptide-resistant Bacteriamentioning

confidence: 99%

Current perspectives on glycopeptide resistance

et al. 1995

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“…(vancomycin MIC 90 128 μg ml −1 , range 16–128 μg ml −1 ), and single isolates of Gemella haemolysans (vancomycin MIC>32 μg ml −1 ) and Corynebacterium spp. (vancomycin MIC 32 μg ml −1 ) [25,42–44]. The mechanism of resistance to vancomycin in these isolates in unknown, although no enterococcal vanA or vanB genes were identified in C. innocuum using a polymerase chain reaction assay (Patel, unpublished results).…”

mentioning

confidence: 99%

Enterococcal-type glycopeptide resistance genes in non-enterococcal organisms

Patel

2000

FEMS Microbiology Letters

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Although the emergence of vancomycin-resistant enterococci can be attributed, in part, to the increasing use of vancomycin in clinical practice, and glycopeptide use in animal husbandry, the origins of the enterococcal vancomycin resistance genes are not clear. The vancomycin resistance-associated genes in Enterococcus gallinarum, Enterococcus casseliflavus/flavescens, Lactobacillus spp., Leuconostoc spp., Pediococcus spp., and Erysipelothrix rhusiopathiae, are not the source of the high-level vancomycin resistance-associated genes in enterococci. There are, however, environmental organisms which have been found to have gene clusters homologous to the enterococcal vanA, vanB and vanC gene clusters; these include the biopesticide Paenibacillus popilliae, and, to a lesser extent, the glycopeptide-producing organisms Amycolatopsis orientalis and Streptomyces toyocaensis. Still, the exact sources of the enterococcal vancomycin resistance genes remain a mystery.

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“…Although there have been reports of vancomycin resistance in Corynebacterium species isolates from non-ocular infections, all of the isolates in the current series were sensitive to vancomycin. 43, 44 All of the isolates tested were sensitive to imipenem and 75% (6 of 8) were sensitive to ciprofloxacin, the antibiotics used in the reported cases of vancomycin-resistant Corynebacterium species.…”

Section: Discussionmentioning

confidence: 98%

Endophthalmitis Caused by Corynebacterium Species: Clinical Features, Antibiotic Susceptibility, and Treatment Outcomes

Kuriyan

Sridhar

Flynn

et al. 2017

Ophthalmology Retina

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Purpose To report the clinical features, antibiotic susceptibility profiles, treatment, and visual acuity (VA) outcomes of endophthalmitis caused by Corynebacterium species. Design Retrospective case series. Subjects Patients with endophthalmitis caused by Corynebacterium species. Methods Microbiology database records were retrospectively reviewed for all patients with endophthalmitis caused by Corynebacterium species from January 1, 1990 to December 31, 2012 at a large university referral center. The corresponding clinical records were then reviewed to evaluate the endophthalmitis clinical features and treatment outcomes. Main Outcome Measures presenting clinical features, visual acuity outcomes, and antibiotic susceptibility patterns. Results Of 10 patients identified, clinical settings included post-cataract surgery (n = 6), post-penetrating keratoplasty (n = 2), and post-trabeculectomy (n = 2). The mean time from surgical procedure to presentation with endophthalmitis was 6.8 months (range: 1 day to 28 months). All isolates were vancomycin susceptible. Presenting VA ranged from 7/200 to no light perception. Initial treatment strategies were vitreous tap and intravitreal antibiotic injection (n = 5) and pars plana vitrectomy with intravitreal antibiotic injection (n = 5). VA outcomes were ≥ 20/60 in 5 (50%) of 10 patients and ≤ 20/400 in 5 (50%) of 10 patients. Conclusions The most common clinical setting was post-cataract surgery. All isolates were susceptible to vancomycin. Despite prompt treatment with appropriate antibiotics, there were variable visual outcomes.

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Vancomycin-resistant Corynebacterium species causing prosthetic valve endocarditis successfully treated with imipenem and ciprofloxacin

Cited by 12 publications

References 29 publications

Current perspectives on glycopeptide resistance

Current perspectives on glycopeptide resistance

Enterococcal-type glycopeptide resistance genes in non-enterococcal organisms

Endophthalmitis Caused by Corynebacterium Species: Clinical Features, Antibiotic Susceptibility, and Treatment Outcomes

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