Vancomycin Ointment for MRSA Infection at a Cranioplasty Site

Ikeda, Hiroaki; Kurisu, Kaoru; Kihira, Kenji

doi:10.1345/aph.1d178

Cited by 12 publications

(7 citation statements)

References 3 publications

(1 reference statement)

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“…The MIC 50 and MIC 90 of Malternifolia essential oil and its major components in comparison to representatives of the major antibiotic families are reported in Table I. All the antibiotics compared to TTO and terpinen 4-01 are only for topical use (fusidic acid and mupirocin), or can be found included in ointments or ophthalmic solutions or used during surgery as topical drugs (12)(13)(14)(15)(16)(17) Malternifolia essential oil and terpinen-d-ol already showed cidal activity towards Siaureus 8325.4 after 5 min. This activity was dose-dependent because the culture killing was much greater and quicker after exposure to 2x and 4x MIC values (Fig.…”

Section: Discussionmentioning

confidence: 99%

Melaleuca Alternifolia Essential Oil Possesses Potent Anti-Staphylococcal Activity Extended to Strains Resistant to Antibiotics

Ferrini

Mannoni²,

Aureli³

et al. 2006

Int J Immunopathol Pharmacol

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Melaleuca alternifolia Cheel essential oil (TTO) and its major component terplnen-t-ol were examined against a large number of clinical isolates of Staphylococcus aureus to establish their antistaphylococcal activities. Classic and established procedures were used to study M.I.e., time-kill curves, synergism and mutational frequency. The anti-staphylococcal activity of terpinen-d-ol and TTO were superior to those of antibiotics belonging to the major families (all the tested drugs are for topical use or included in ointments, eye drops or used during surgery); terpinen 4-01 and TTO were active against strains resistant to mupirocin, fusidic acid, vancomycin, methicillin and linezolid. TTO and terpinen-4-01 were bactericidal as revealed by time-kill curves; the frequency of mutational frequency to TTO was < 2.9xl0 9 • The study demonstrates good anti-staphylococcal activity of TTO and terpinen-a-ol against a large number of S.aureus isolates and suggests the possible application of these agents for topical treatment of staphylococcal infections. This is the first extensive study on the anti-staphylococcal activity ofTTO. The results suggest that this compound may have application as a topical agent for the control of superficial staphylococcal infections, including activity against organisms resistant to antibiotics which can be used, or are specific, for topical use.

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Section: Discussionmentioning

confidence: 99%

Melaleuca Alternifolia Essential Oil Possesses Potent Anti-Staphylococcal Activity Extended to Strains Resistant to Antibiotics

Ferrini

Mannoni²,

Aureli³

et al. 2006

Int J Immunopathol Pharmacol

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“…MRSA has been reported in an iliopsoas hematoma consequent to a prosthetic graft infection and in an autologous bone graft at a cranioplasty site [8,9].…”

Section: Discussionmentioning

confidence: 99%

Methicillin-ResistantStaphylococcus AureusFollowing Leech Application at a Congested Flap after a Mastectomy

Hwang

Kim

2017

Arch Aesthetic Plast Surg

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“…However, PMMA impregnated with antibiotics, preoperative prophylactic vancomycin for Methicillin-resistant Staphylococcus aureus (MRSA) and prophylactic vancomycin ointment at the cranioplasty site shows low grade evidence 25434455)…”

Section: Antibiotics On Surgical Fieldmentioning

confidence: 99%

“…The difference of the clinical outcome between synthetic materials and autologous bone graft in cranioplasty is very small 3435394048). Some authors report lower complication with synthetic materials 825262728). Some reports say the total cumulative cost, including complication risks and treatments, was not significantly different between titanium and autologous bone flaps in United States of America & Canada 2450).…”

Section: Cost Effectiveness Of Autologous Skull Flap In Koreamentioning

confidence: 99%

Review of Cranioplasty after Decompressive Craniectomy

Cho

Kang

2017

Korean J Neurotrauma

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Cranioplasty is an in evitable operation conducted after decompressive craniectomy (DC). The primary goals of cranioplasty after DC are to protect the brain, achieve a natural appearance and prevent sinking skin flap syndrome (or syndrome of the trephined). Furthermore, restoring patients' functional outcome and supplementing external defects helps patients improve their self-esteem. Although early cranioplasty is preferred in recent year, optimal timing for cranioplasty remains a controversial topic. Autologous bone flaps are the most ideal substitute for cranioplasty. Complications associated with cranioplasty are also variable, however, post-surgical infection is most common. Many new materials and techniques for cranioplasty are introduced. Cost-benefit analysis of these new materials and techniques can result in different outcomes from different healthcare systems.

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Vancomycin Ointment for MRSA Infection at a Cranioplasty Site

Abstract: Topical administration of vancomycin was more effective than systemic administration in the treatment of our patient's MRSA skull implant infection. No adverse effects from topical treatment were encountered over 3 years.

Cited by 12 publications

References 3 publications

Melaleuca Alternifolia Essential Oil Possesses Potent Anti-Staphylococcal Activity Extended to Strains Resistant to Antibiotics

Melaleuca Alternifolia Essential Oil Possesses Potent Anti-Staphylococcal Activity Extended to Strains Resistant to Antibiotics

Methicillin-ResistantStaphylococcus AureusFollowing Leech Application at a Congested Flap after a Mastectomy

Review of Cranioplasty after Decompressive Craniectomy

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