Vancomycin impairs macrophage fungal killing by disrupting mitochondrial morphology and function
Ebrima Bojang,
Lozan Sheriff,
Man Shun Fu
et al.
Abstract:Vancomycin is a widely prescribed antibiotic used in the treatment of Gram-positive bacterial infections. We recently showed that this antibiotic disrupted protective anti-fungal immune responses via microbiome dysbiosis, enhancing susceptibility to invasive candidiasis. Antibiotics are an independent risk factor for developing this life-threatening fungal infection, but whether microbiota-independent mechanisms also drive this association is not clear. Here, we show that vancomycin directly impairs macrophage… Show more
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