Vancomycin Functionalized Nanoparticles for Bactericidal Biomaterial Surfaces

Abstract

In this paper, we describe a simple and powerful way to synthesize antibacterial biomaterials with applications as implants in orthopedic surgery. Such implants are obtained by covalently grafting onto the Ti90A16 V4 alloy surface with vancomycin-functionalized nanoparticles. Nanoparticles were produced by ring-opening metathesis polymerization of α-norbornenyl-ω-vancomycin poly(ethylene oxide) macromonomers. Vancomycin is an interesting candidate because of its use in the field of implant associated infection as it is a glycopeptide which acts on bacterial walls. As a consequence, vancomycin does not need to be released for it to be active. In the first part of this paper, the synthesis and the complete characterization of these materials are described. In a second part, the in vitro antibacterial behavior is analyzed and discussed.

Covalent Immobilization of Enoxacin onto Titanium Implant Surfaces for Inhibiting Multiple Bacterial Species Infection and In Vivo Methicillin-Resistant Staphylococcus aureus Infection Prophylaxis

“…Ti silanized with 3-aminopropyltriethoxysilane (APTES) forms three siloxy bonds (TiOOOSiO) with the Ti-oxide surface and exposes a primary amine group for further chemical covalent reactions (31)(32)(33). Enoxacin is effective against many Gram-positive and Gram-negative bacteria by interfering with the DNA replication of the bacteria.…”

Electrophoretic deposition of colloidal particles on Mg with cytocompatibility, antibacterial performance, and corrosion resistance

“…Because once bacteria attached and formed biofilms on the surface of biomaterials, it is difficult to remove them, and this would result in implant failure and require repeated surgery [46]. Fig.…”

Amphiphilic water soluble cationic ring opening metathesis copolymer as an antibacterial agent

“…Research on cationic polymers has been growing in the development of new generation of antibiotics . Moreover, to overcome bacterial infection stemming from medical devices, antibacterial polymers, biomaterials, and bio‐films have been incorporated or directly applied onto the surfaces of medical devices and surgery equipments …”

“…[28][29][30] Moreover, to overcome bacterial infection stemming from medical devices, antibacterial polymers, biomaterials, and bio-films have been incorporated or directly applied onto the surfaces of medical devices and surgery equipments. [31][32][33][34] Like cationic antimicrobial host defense peptides, antimicrobial cationic polymers mainly consist of two functional components: one is the based on cationic moieties and segments feature the hydrophobic groups. [35] The cationic functionality may bind to anionic bacterial cell membranes by electrostatic interactions.…”