Abstract:Background: The pharmacodynamic and pharmacokinetic profiles of vancomycin in neonatal population have been previously reported. However, a consensus still has not been reached about optimal recommended dose. Few studies on neonatal population are available relating particularly to distribution of pathogens and clinical outcome.Therefore, we sought to optimise the drug-dosing regimen based on Monte Carlo Simulation and conducted a retrospective observational study to assess the trough concentration and clinica… Show more
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