Vancomycin dosage requirements among pediatric intensive care unit patients with normal renal function

Achieving Therapeutic Vancomycin Levels in Pediatric Patients

“…Additional variables affecting critically ill patients in the PICU may not be representative of pharmacokinetics in general pediatrics. 6,16 The findings reported here support the hypothesis that different pediatric age groups require different weight-based daily doses of vancomycin. In this study, patients 6 to 23 months and 2 to 12 years of age required the highest daily doses of vancomycin.…”

Evaluation of Vancomycin Dosing and Corresponding Drug Concentrations in Pediatric Patients

“…2 Traditional dosing of 40 mg/kg per day (10 mg/kg per dose every 6 hours) has been shown in multiple studies to fall short of these target trough concentrations, and doses higher than the IDSA-recommended 60 mg/kg per day are often needed. [7][8][9][10][11] However, for many practitioners, the use of increasing doses raises concern about patient tolerability and safety, especially with regard to vancomycin-induced nephrotoxicity (VIN). 7,8,[12][13][14] To begin to formulate a dosing approach to reach recommended vancomycin trough targets, more information about the infl uence of developmental factors in pediatrics would be desirable.…”

Drug use density in critically ill children and newborns: Analysis of various methodologies

“…Vancomycin continues to be a frequently prescribed antibiotic for suspected or confirmed Gram-positive infections (4,5). Treatment of Gram-positive cocci infections, including vancomycinresistant enterococci, continues to present a challenge for physicians treating patients admitted to pediatric intensive care units (PICUs).…”