Vancomycin added to the wash solution of the cell-saver. Effect on bacterial contamination

Pérez-Ferrer, Antonio; Gredilla-Díaz, E.; Vicente-Sánchez, J. de; Suay, R. Navarro; Gilsanz-Rodríguez, F.

doi:10.1016/j.redare.2016.10.001

Cited by 5 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, quantitative measurement of the bacterial load should be performed. To further decrease the bacterial load, the washing process could be performed under the plenum to reduce contamination via air, and antibiotics could be added to the erythrocyte concentrate to reduce the bacterial load, as proven by Lenzen and Perez-Ferrer et al [10,21] Gentamicin (8 mg/L) and vancomycin (40 mg/L) would eradicate all bacteria found in the blood cultures of this study. A new emerging alternative to reduce microbial load could be phototherapy, which shows promising results [22].…”

Section: Discussionmentioning

confidence: 84%

Cell salvage in burn excisional surgery

Gigengack

Gemert

Oen

et al. 2021

Burns

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 84%

Cell salvage in burn excisional surgery

Gigengack

Gemert

Oen

et al. 2021

Burns

View full text Add to dashboard Cite

“…Implementing comprehensive nursing This study is subject to some limitations, including the fact that the study population was relatively small. Recent reports have suggested that adding vancomycin can eliminate the bacterial of sRBCs when using CS devices (27), but this approach remains to be tested in the context of cardiac surgery. In future studies, we will focus on actively collaborating with other centers to increase the study sample size and to conduct bacterial sensitivity testing aimed at identifying the lowest concentrations of the most effective antibiotics capable of lowering rates of culture positivity.…”

Section: Postoperative Infectionsmentioning

confidence: 99%

Risk factors associated with positive bacterial culture in salvaged red blood cells during cardiac surgery and postoperative infection incidence: A prospective cohort study

Zhou

Chen

et al. 2023

Front. Med.

View full text Add to dashboard Cite

BackgroundThis study was designed to explore factors associated with the incidence of positive bacterial culture of salvaged red blood cells (sRBCs) recovered with a Cell Saver instrument during cardiac surgery and the impact of such positive outcomes on postoperative infection-related morbidity.MethodsThe cohort study enrolled 204 patients scheduled for cardiac surgery with intraoperative blood cell salvage and retransfusion from July 2021 to July 2022. These patients were stratified into two groups based on intraoperative sRBCs bacterial culture results: culture (+) and culture (−) groups. Preoperative and intraoperative variables were compared between these groups aim to detect possible predictors of positive culture in sRBCs. In addition, differences in postoperative infection-related morbidity and other clinical outcomes were compared between these groups.ResultsOf these patients, 49% were sRBCs culture (+), with Staphylococcus epidermidis as the most commonly identified pathogen. Risk factors independently associated with the risk of positive culture in sRBCs included BMI ≥25 kg/m2, a history of smoking, an operative duration ≥277.5 min, the higher number of staff in the operating room and higher surgical case order. Patients in the sRBCs culture (+) group exhibited a longer average ICU stay [3.5 days (2.0–6.0) vs. 2 days (1.0–4.0), P < 0.01], a longer duration of ventilation [20.45 h (12.0–17.8) vs. 13 h (11.0–17.0, P = 0.02)], underwent more allogeneic blood transfusions, exhibited higher transfusion-related costs [2,962 (1,683.0–5,608.8) vs. 2,525 (1,532.3–3,595.0), P = 0.01], and had higher rates of postoperative infections (22 vs. 9.6%, P = 0.02) as compared to patients in the sRBCs culture (−) group. In addition, culture (+) in sRBCs was an independent risk factor for postoperative infection (OR 2.62, 95% CI 1.16–5.90, P = 0.02).ConclusionStaphylococcus epidermidis was the most common pathogen detected in sRBCs in the culture (+) group in this study, identifying it as a potential driver of postoperative infection. Positive sRBCs culture may contribute to postoperative infection and its incidence was significantly associated with patient BMI, history of smoking, operative duration, the number of staff in the operating room and surgical case order.

show abstract

“…Whether the bacterial load can be eliminated by washing techniques [85,86] has been debated, as blood contamination with penetrating trauma or enteral injury can lead to disseminated infection. One option to counteract this risk may be the administration of antibiotics at the time of re-transfusion of autologous blood [87].…”

Section: Weak Evidence Of Cell Salvage In Civilian Trauma Bleedingmentioning

confidence: 99%

Cell Salvage in Oncological Surgery, Peripartum Haemorrhage and Trauma

2022

View full text Add to dashboard Cite

Oncological surgery, obstetric haemorrhage and severe trauma are the most challenging conditions for establishing clinical recommendations for the use of cell salvage. When the likelihood of allogeneic transfusion is high, the intraoperative use of this blood-saving technique would be justified, but specific patient selection criteria are needed. The main concerns in the case of oncological surgery are the reinfusion of tumour cells, thereby increasing the risk of metastasis. This threat could be minimized, which may help to rationalize its indication. In severe peripartum haemorrhage, cell salvage has not proven cost-effective, damage control techniques have been developed, and, given the risk of fetomaternal alloimmunization and amniotic fluid embolism, it is increasingly out of use. In trauma, bleeding may originate from multiple sites, coagulopathy may develop, and it should be evaluated whether re-transfusion of autologous blood collected from uncontaminated organ cavities would be feasible. General safety measures include washing recovered blood and its passage through leukocyte depletion filters. To date, no well-defined indications for cell salvage have been established for these pathologies, but with accurate case selection and selective implementation, it could become safe and effective. Randomized clinical trials are urgently needed.

show abstract

Vancomycin added to the wash solution of the cell-saver. Effect on bacterial contamination

Cited by 5 publications

References 16 publications

Cell salvage in burn excisional surgery

Cell salvage in burn excisional surgery

Risk factors associated with positive bacterial culture in salvaged red blood cells during cardiac surgery and postoperative infection incidence: A prospective cohort study

Cell Salvage in Oncological Surgery, Peripartum Haemorrhage and Trauma

Contact Info

Product

Resources

About