Abstract:Various substituted benzimidazoles have been successfully synthesized in aqueous medium by developing VO(acac) 2 -Cu(OTf) 2 catalytic system. A green synthetic protocol has been created in presence of water and cetyltrimethyl ammonium bromide (CTAB) system in an organic solvent free condition. This chemoselective cyclocondensation cumoxidation process occurred in aqueous media. In this suitable method easily synthesized 2-Substituted benzimidazoles with good yields and no 1,2-disubstituted by-products were not… Show more
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