Vanadium(V) complexes with salicylaldehyde semicarbazone derivatives bearing in vitro anti-tumor activity toward kidney tumor cells (TK-10): crystal structure of [VVO2(5-bromosalicylaldehyde semicarbazone)]

Synthesis, characterization and biological properties of thienyl derived triazole Schiff bases and their oxovanadium(IV) complexes

“…Presently, the vanadium metal chemistry is gaining attention for its remarkable activities such as antimicrobial 11 , antitumor 12 , and most recently as insulin mimetic 13 . In continuation of our previous efforts to design and synthesize biologically active compounds, we have prepared a new series of thiophene derived triazole Schiff base ligands (L 1 )- (L 5 ) and their oxovanadium(IV) complexes (1)-(5) (Scheme 1) and wish to report in this paper their characterization and in vitro antibacterial, antifungal and cytotoxic properties.…”

Chemistry of molecular and supramolecular structures of vanadium(IV) and dioxygen-bridged V(V) complexes incorporating tridentate hydrazone ligands

“…Thus, the insulin-enhancing, insulin mimetic properties of oxovanadium(V) complexes, their use as model complexes for the active site of vanadoenzymes, and their use as catalysts in biological and industrial processes have been reported [5][6][7][8][9]. Furthermore, these compounds exhibit potential as anti-tumour agents by inhibiting growth of malignant cell lines by induction of cell-cycle arrest and/or cytotoxic effects [10]. Although most known insulinlike complexes contain vanadium in oxidation state +IV, vanadium(V) compounds have also been found to have insulin-like properties [11].…”

Suppression of cell proliferation, induction of apoptosis and cell cycle arrest: Chemopreventive activity of vanadium in vivo and in vitro

“…[3][4][5][6] The uniqueness of vanadium is that it is a micronutrient and is included in the list of 40 essential micronutrients that are required in small amounts for normal metabolism. Accordingly, it has been incorporated in many multinational pharmaceutical preparations along with vitamins and other trace elements for maintenance of normal health.…”