Vanadium pentoxide nanoparticle mediated perturbations in cellular redox balance and the paradigm of autophagy to apoptosis

Suma, Parvathy Radhakrishna Pillai; Padmanabhan, Renjini Ambika; Telukutla, Srinivasa Reddy; Ravindran, Rishith; Velikkakath, Anoop Kumar G.; Dekiwadia, Chaitali; Paul, Willi; Laloraya, Malini; Srinivasula, Srinivasa M.; Bhosale, Sheshanath V.; Jayasree, Ramapurath S.

doi:10.1016/j.freeradbiomed.2020.10.008

Cited by 27 publications

(13 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…V, a transition metal, participates in redox behavior and induces the production of ROS. Many scholars have pointed out that V induced cells to produce excessive amounts of ROS, leading to oxidative stress, which in turn triggered mitochondrial dysfunction ( 37 , 38 ). Meanwhile, the antioxidative system can scavenge ROS through free radical scavenging antioxidant enzymes and non-enzymatic antioxidants ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Vanadium Induces Oxidative Stress and Mitochondrial Quality Control Disorder in the Heart of Ducks

Xiong

Xing

et al. 2021

Front. Vet. Sci.

View full text Add to dashboard Cite

Vanadium (V) is an ultra-trace element presenting in humans and animals, but excessive V can cause toxic effects. Mitochondrial quality control (MQC) is an essential process for maintaining mitochondrial functions, but the relationship between V toxicity and MQC is unclear. To investigate the effects of excessive V on oxidative stress and MQC in duck hearts, 72 ducks were randomly divided into two groups, including the control group and the V group (30 mg of V/kg dry matter). The cardiac tissues were collected for the histomorphology observation and oxidative stress status evaluation at 22 and 44 days. In addition, the mRNA and protein levels of MQC-related factors were also analyzed. The results showed that excessive V could trigger vacuolar degeneration, granular degeneration, as well as mitochondrial vacuolization and swelling in myocardial cells. In addition, CAT activity was elevated in two time points, while T-SOD activity was increased in 22 days but decreased in 44 days after V treatment. Meanwhile, excessive V intake could also increase the number of Drp1 puncta, the mRNA levels of mitochondrial fission–related factors (Drp1and MFF), and protein (MFF) level, but decrease the number of Parkin puncta and the mitochondrial biogenesis (PGC-1α, NRF-1, and TFAM), mitochondrial fusion (OPA1, Mfn1, and Mfn2), and mitophagy (Parkin, PINK1, P62, and LC3B) related mRNA levels and protein (PGC-1α, Mfn1, Mfn2, PINK1) levels. Collectively, our results suggested that excessive V could induce oxidative stress and MQC disorder in the heart of ducks.

show abstract

Section: Discussionmentioning

confidence: 99%

Vanadium Induces Oxidative Stress and Mitochondrial Quality Control Disorder in the Heart of Ducks

Xiong

Xing

et al. 2021

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…Metal nanoparticles offer opportunities for their use in cell imaging as biosensors and drug-delivery systems. This is related to their small size and reactive surface area [ 89 ]. Due to their multifunctionality, nanotechnology-based imaging and therapy could be a breakthrough in cancer research [ 103 ].…”

Section: Discussionmentioning

confidence: 99%

“…These ions can pass through the membranes of organelles and further enhance the concentration of intracellular free radicals ( Figure 5 ). The extended uptake of V NPs could mobilize the cellular defense machinery, thereby raising the level of intracellular ROS even more significantly [ 89 ].…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

An Overview of the Importance of Transition-Metal Nanoparticles in Cancer Research

Szewczyk

Roszczenko

Czarnomysy

et al. 2022

IJMS

View full text Add to dashboard Cite

Several authorities have implied that nanotechnology has a significant future in the development of advanced cancer therapies. Nanotechnology makes it possible to simultaneously administer drug combinations and engage the immune system to fight cancer. Nanoparticles can locate metastases in different organs and deliver medications to them. Using them allows for the effective reduction of tumors with minimal toxicity to healthy tissue. Transition-metal nanoparticles, through Fenton-type or Haber–Weiss-type reactions, generate reactive oxygen species. Through oxidative stress, the particles induce cell death via different pathways. The main limitation of the particles is their toxicity. Certain factors can control toxicity, such as route of administration, size, aggregation state, surface functionalization, or oxidation state. In this review, we attempt to discuss the effects and toxicity of transition-metal nanoparticles.

show abstract

“…Depending on the situation, NP induced mitochondrial dysfunction and cell death may be detrimental, such as if this occurs in healthy cells and organisms; or may be beneficial and the toxicity used to advantage such as with the anticancer activity of various metallic NPs and NPs with antioxidant properties [ 264 , 265 ]. For example, in vitro studies comparing the toxicity of various NPs on cancer and noncancer cell lines have found Ag NPs [ 261 ], Au NPs [ 260 ], vanadium pentoxide NPs [ 266 ], lipophilic bismuth NPs [ 265 , 267 ], and graphene oxide NPs [ 37 ] to be preferentially toxic to cancer cells than to noncancer cells. A summary of the effects of NPs on mitochondrial function and energy production is shown in Table 5 .…”

Section: Effects Of Nanoparticles On Mitochondrial Functionmentioning

confidence: 99%

Nanoparticle Effects on Stress Response Pathways and Nanoparticle–Protein Interactions

Cameron

Sheng

Hosseinian

et al. 2022

IJMS

View full text Add to dashboard Cite

Nanoparticles (NPs) are increasingly used in a wide variety of applications and products; however, NPs may affect stress response pathways and interact with proteins in biological systems. This review article will provide an overview of the beneficial and detrimental effects of NPs on stress response pathways with a focus on NP–protein interactions. Depending upon the particular NP, experimental model system, and dose and exposure conditions, the introduction of NPs may have either positive or negative effects. Cellular processes such as the development of oxidative stress, the initiation of the inflammatory response, mitochondrial function, detoxification, and alterations to signaling pathways are all affected by the introduction of NPs. In terms of tissue-specific effects, the local microenvironment can have a profound effect on whether an NP is beneficial or harmful to cells. Interactions of NPs with metal-binding proteins (zinc, copper, iron and calcium) affect both their structure and function. This review will provide insights into the current knowledge of protein-based nanotoxicology and closely examines the targets of specific NPs.

show abstract

Vanadium pentoxide nanoparticle mediated perturbations in cellular redox balance and the paradigm of autophagy to apoptosis

Cited by 27 publications

References 43 publications

Vanadium Induces Oxidative Stress and Mitochondrial Quality Control Disorder in the Heart of Ducks

Vanadium Induces Oxidative Stress and Mitochondrial Quality Control Disorder in the Heart of Ducks

An Overview of the Importance of Transition-Metal Nanoparticles in Cancer Research

Nanoparticle Effects on Stress Response Pathways and Nanoparticle–Protein Interactions

Contact Info

Product

Resources

About