Vanadium pentoxide induces hematological, oxidative stress and histological changes in Oryctolagus cuniculus

Nnama, Augustine U.; Ekeh, Felicia Nkechi; Aguzie, Ifeanyi Oscar; Udegbunam, Sunday Ositadimma; Nwani, Christopher Didigwu

doi:10.1016/j.hazadv.2022.100048

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…This result agrees with Uddin et al [15] that Naringin can act as an anti-apoptotic drug in neurodegeneration by inducing Glial cell line-derived neurotrophic factor (GDNF) which is a protein that allows for the survival of nerve cells that have been lost as a result of the induced neurotoxicity. It is evident from this study that vanadium causes degenerative changes in the Substantia nigra (SNc) and Caudate putamen (CPu) which involves loss of neuronal cells with impaired motor function, and this is in line with statement made in Nnama et al [16] .…”

Section: Discussionsupporting

confidence: 92%

Naringin ameliorates motor dysfunction and exerts neuroprotective role against vanadium-induced neurotoxicity

Adekeye

Fafure

Ogunsemowo

et al. 2022

AIMSN

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<abstract> <p>Exposure to vanadium has been known to lead to a progressive neurodegenerative disorder-like Parkinson's disease. Naringin is a known flavonoid glycoside that is mostly seen in the flesh of grapefruit and orange and is believed to have protective effects for the treatment of neurodegenerative disorders. This study sought to investigate the role of Naringin in the treatment of vanadium-induced neurotoxicity. Vanadium (10 mg/kg BW) was injected intraperitoneally to induce motor dysfunction, followed by treatment with Naringin (30 mg/kg BW) intraperitoneally for 14 days. Oxidative stress imbalance was monitored by checking Glutathione Peroxidase (GPX) and Catalase levels. Histological and immunohistochemical alterations were observed using RBFOX3 polyclonal antibody to determine neuronal cell distribution and NLRP3 inflammasome antibody as a marker of inflammation. Exposure to vanadium induces neurotoxicity by significantly increasing the Catalase and Glutathione Peroxidase (GPX) levels. Vanadium administration also led to increased inflammatory cells and a significant reduction of the viable neuronal cells in the SNc and CPu. Treatment with Naringin showed a neuroprotective role by dependently restoring the Catalase and Glutathione Peroxidase (GPX) levels, inflammasome activation, and neuronal damage in the SNc and CPu. Naringin demonstrated anti-oxidative, and anti-inflammatory responses by inhibiting oxidative stress, and inflammation and exerts neuroprotective effects by inhibiting apoptosis following vanadium-induced neurotoxicity in adult Wistar rats.</p> </abstract>

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Section: Discussionsupporting

confidence: 92%

Naringin ameliorates motor dysfunction and exerts neuroprotective role against vanadium-induced neurotoxicity

Adekeye

Fafure

Ogunsemowo

et al. 2022

AIMSN

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“…One study evaluating the effect of vanadate and V 10 on the activity of SOD and CAT in cardiac tissue showed a 115% increase in SOD activity and no change in CAT activity with exposure to metavanadate and a 20% increase in SOD activity and a 55% decrease in CAT activity with exposure to V 10 [ 28 ]. A study looking at vanadium pentoxide exposure in rabbits found a decrease in SOD (14.3%) and CAT (30.0%) activity with a 42.9–60.0% increase in LPO [ 73 ]. No study to date has compared the effects of vanadium on LPO using different biomarkers.…”

Section: Reactive Oxygen Species and Lipid Peroxidationmentioning

confidence: 99%

Biological Consequences of Vanadium Effects on Formation of Reactive Oxygen Species and Lipid Peroxidation

Aureliano

Sousa‐Coelho

Dolan

et al. 2023

IJMS

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Lipid peroxidation (LPO), a process that affects human health, can be induced by exposure to vanadium salts and compounds. LPO is often exacerbated by oxidation stress, with some forms of vanadium providing protective effects. The LPO reaction involves the oxidation of the alkene bonds, primarily in polyunsaturated fatty acids, in a chain reaction to form radical and reactive oxygen species (ROS). LPO reactions typically affect cellular membranes through direct effects on membrane structure and function as well as impacting other cellular functions due to increases in ROS. Although LPO effects on mitochondrial function have been studied in detail, other cellular components and organelles are affected. Because vanadium salts and complexes can induce ROS formation both directly and indirectly, the study of LPO arising from increased ROS should include investigations of both processes. This is made more challenging by the range of vanadium species that exist under physiological conditions and the diverse effects of these species. Thus, complex vanadium chemistry requires speciation studies of vanadium to evaluate the direct and indirect effects of the various species that are present during vanadium exposure. Undoubtedly, speciation is important in assessing how vanadium exerts effects in biological systems and is likely the underlying cause for some of the beneficial effects reported in cancerous, diabetic, neurodegenerative conditions and other diseased tissues impacted by LPO processes. Speciation of vanadium, together with investigations of ROS and LPO, should be considered in future biological studies evaluating vanadium effects on the formation of ROS and on LPO in cells, tissues, and organisms as discussed in this review.

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Synthesis, design,in silico,in vitroandin vivo(streptozotocin-induced diabetes in mice) biological evaluation of novelsN-arylacetamide derivatives

Mortada,

Guerrab,

Missioui

et al. 2023

Journal of Biomolecular Structure and Dynamics

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Vanadium pentoxide induces hematological, oxidative stress and histological changes in Oryctolagus cuniculus

Cited by 5 publications

References 49 publications

Naringin ameliorates motor dysfunction and exerts neuroprotective role against vanadium-induced neurotoxicity

Naringin ameliorates motor dysfunction and exerts neuroprotective role against vanadium-induced neurotoxicity

Biological Consequences of Vanadium Effects on Formation of Reactive Oxygen Species and Lipid Peroxidation

Synthesis, design,in silico,in vitroandin vivo(streptozotocin-induced diabetes in mice) biological evaluation of novelsN-arylacetamide derivatives

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