Vanadium(IV) and copper(II) complexes of salicylaldimines and aromatic heterocycles: Cytotoxicity, DNA binding and DNA cleavage properties

Self-recognition of the racemic ligand in the formation of homochiral dinuclear V(V) complex: In vitro anticancer activity, DNA and HSA interaction

“…Interestingly, the toxic effects of the complex on the normal fibroblast cells were significantly less than cancer cells, as the maximum cell mortality of 12.3% obtained after 48 h incubation of fibroblast cells with 100 µM the complex. The results indicated the higher anticancer activity of the synthesized complex thanpreviously reported vanadium complexes[42][43][44]. Moreover, the complex showed low toxicity on normal human fibroblast cells that is critical for the development of antitumor agents.…”

Stabilities and Biological Activities of Vanadium Drugs: What is the Nature of the Active Species?

“…[73][74][75] In recent reviews, [2,3,9] mostp otential Va nti-cancero ra ntiparasitic drugsd iscussed werem ixed-ligand complexes with an aromatic diimine as one of the ligands, but the role of ligand release in their biological activity has been overlooked. [76,77] However,s omec omplexes, e.g., 7 (where the second ligand is as alicylaldehydes emicarbazone derivative), were more toxic than the free diimine ligand to the Trypanosoma cruzi parasite, and less toxic than the ligand in mammalian cells (Table S1), [78] which implies at least partial stability of the complexes under the conditions of the biological assays.…”

“…[24,68] Mixed-ligand V IV complexes with at ridentate O,N,O-donor ligand (of Schiff base or semicarbazone type, e.g., 7,S ection 2.5) and abidentate aromatic diimine ligand have featured prominently in recent cytotoxicity studies on Vc omplexes. [2,3,9,[76][77][78] Although slowo xidation of V IV to V V speciesi n polar organic solvents and dissociation of the O,N,O-donor ligands in aqueousb uffer solutionsh ave been mentioned, [76][77][78] reactivity studies in biological media are lacking. Such studies are much needed to determine whether their activities are due to free ligands( or their Cu II complexes formed in biological media), [51,73,83] Vs pecies,o rb oth (Section3).…”

Synthesis, characterization, DNA interaction, apoptosis and molecular docking of Cu(II) and Mn(II) complexes with endo‐norbornene‐cis‐5,6‐dicarboxylic acid

“…Under these conditions, the fluorescence intensity of the respective complexes, extracted HC‐DNA and ethidium bromide (EtBr) was very small and could be ignored. The interaction of the respective complexes with DNA in vitro was studied as described in the literature …”