Vanadium Inhalation in a Mouse Model for the Understanding of Air‐Suspended Particle Systemic Repercussion

Fortoul, Teresa I.; Rodríguez-Lara, Vianey; González-Villalva, Adriana; Rojas-Lemus, Marcela; Cano-Gutiérrez, Gumaro; Ustarroz-Cano, Martha; Colı́n-Barenque, Laura; Montaño, Luis F.; García-Pelez, I.; Bizarro-Nevares, Patrícia; López-Valdéz, Nelly; Falcón-Rodríguez, Carlos Iván; Jimenez-Martínez, Ruben; Ruiz-Guerrero, M. L.; López-Zepeda, Lorena Sofía; Morales-Rivero, Alonso; Muñiz-Rivera-Cambas, A.

doi:10.1155/2011/951043

Cited by 33 publications

(44 citation statements)

References 48 publications

(63 reference statements)

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“…We found that vanadium exposed mice presented a shift of the normal cortex-medulla relationship, showing a much thinner medulla and the presence of medulla-like areas within the cortex regions. These changes suggest an alteration of the immune response [69,89]. In addition to these findings we have reported a decrease in the presence of CD11c, a dendritic cell marker, and MHCII an antigen presenting cell marker, in the thymus of vanadium-exposed mice.…”

Section: Immunotoxicity Of Metalssupporting

confidence: 70%

“…Thus, genotoxic mutagenic events precede and therefore are the source of cellular malignancy [63]. Studies indicate that nickel induces chromosome aberrations in rats [64]; cadmium [65] and lead [66] causes single strand breaks and alkali-labile sites in mouse cells; in rats uranium causes double strand breaks [67]; iron induces in mice chromosome aberrations and micronuclei; in human beings vanadium produces bases oxidation and micronucleus [68], but in mice produces single strand breaks and micronucleus too [69,70]. Conversely to others metals, titanium showed no adverse effects on DNA in mice cells [71].…”

Section: Genotoxicity and Metalsmentioning

confidence: 99%

“…It goes through the placenta, constituting complexes with transferrin or albumin, and accumulates in the placenta and the fetal tissues. It has been found that vanadium affects the prenatal development, since it produces embryo mortality, fetus toxicity and teratogenicity in mice, rats, hamsters and chickens [69,89]. In humans, it has been proved that the exposure to vanadium during pregnancy is linked to low birth weight.…”

Section: Teratogenesismentioning

confidence: 99%

See 2 more Smart Citations

Health Effects of Metals in Particulate Matter

Fortoul¹,

Rodríguez-Lara²,

González-Villalva³

et al. 2015

Current Air Quality Issues

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Section: Immunotoxicity Of Metalssupporting

confidence: 70%

Section: Genotoxicity and Metalsmentioning

confidence: 99%

Section: Teratogenesismentioning

confidence: 99%

See 1 more Smart Citation

Health Effects of Metals in Particulate Matter

Fortoul¹,

Rodríguez-Lara²,

González-Villalva³

et al. 2015

Current Air Quality Issues

Self Cite

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“…Vanadium (V) is adsorbed into PM and by inhalation reaches the systemic circulation exerting its toxic effect in other organs and tissues (Dockery & Pope 1994;Barceloux 1999). Adverse effects by V exposure in reproductive, nervous, urinary, respiratory and hematopoietic systems have been reported (Aragon et al 2005;Gonzalez-Villalva et al 2009;Fortoul et al 2011Fortoul et al , 2014aRodriguez-Lara et al 2013b;Walters et al 2014). Nevertheless, the effects of V on the immune system are not very well studied and many of the reported results have often been contradictory.…”

Section: Introductionmentioning

confidence: 99%

Sex-based differences in lymphocyte proliferation in the spleen after vanadium inhalation

Rodríguez-Lara

Cambas

Villalva

et al. 2016

Journal of Immunotoxicology

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Vanadium (V) is a transition metal often adhered to particulate matter and released into the atmosphere as vanadium pentoxide (V 2 O 5 ) by the burning of fossil fuels. This air pollutant causes adverse effects in the immune system. Lymphocytosis and splenomegaly have been reported with increased white pulp in mice after V inhalation. The effect of V on the immune system as related to sex has been poorly investigated. This study sought to determine if V inhalation (a) produced lymphoproliferation that could explain the changes previously observed in the spleen and in peripheral blood lymphocyte counts and (b) whether any observed effects differed due to gender. Immunohistochemical analyses of Ki-67, a specific proliferation marker, was made in the spleens of CD-1 male and female mice exposed for 1 h, twice a week, over a 12-week period to V 2 O 5 (at 1.4 mg V 2 O 5 /m 3 ) by whole-body inhalation; similar analyses were performed on spleens of control mice exposed to vehicle (filtered air). The results showed that in male mice there was a significant increase in percentage of Ki-67 immunopositive lymphocytes starting from the second week and until the end of the exposure. The Ki-67 signal was cytoplasmic and nuclear in the exposed males, while in controls the signal was only nuclear. In female mice, V inhalation singificantly increased the percentage of proliferating lymphocytes only after 1 week of exposure. Ki-67 signal was observed only in the nucleus of lymphocytes from the control and exposed females. The results here help to explain the splenomegaly and lymphocytosis observed previously in male mice and support the lymphoproliferative effect induced by V. Lastly, the finding that there was a sex difference in the effect of vanadium on lymphocyte proliferation suggests a role for sex hormones in potential protection against V immunotoxicity; however, further studies are needed to support this hypothesis. ARTICLE HISTORY

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“…Inhalation exposure was performed as described in Fortoul et al (2011). In brief, the wholebody exposures were performed with V 2 O 5 (99.99%, Sigma, St. Louis, MO) as a 0.02-M suspension in saline.…”

Section: Vanadium Exposuresmentioning

confidence: 99%

Thymic cytoarchitecture changes in mice exposed to vanadium

Ustarroz-Cano¹,

García-Peláez²,

Cervantes-Yépez³

et al. 2017

Journal of Immunotoxicology

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The thymus is a vital immune system organ wherein selection of T-lymphocytes occurs in a process regulated by dendritic and epithelial thymic cells. Previously, we have reported that in a mouse model of vanadium inhalation, a decrease in CD11c dendritic cells was observed. In the present study, we report on a thymic cortex-medulla distribution distortion in these hosts due to apparent effects of the inhaled vanadium on cytokeratin-5 (K5 þ ) epithelial cells in the same mouse model -after 1, 2, and 4 weeks of exposure -by immunohistochemistry. These cells -together with dendritic cells -eliminate autoreactive T-cell clones and regulate the production of regulatory T-cells in situ. Because both cell types are involved in the negative selection of autoreactive clones, a potential for an increase in development of autoimmune conditions could be a possible consequence among individuals who might be exposed often to vanadium in air pollution, including dwellers of highly polluted cities with elevated levels of particulate matter onto which vanadium is often adsorbed. ARTICLE HISTORY

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Vanadium Inhalation in a Mouse Model for the Understanding of Air‐Suspended Particle Systemic Repercussion

Cited by 33 publications

References 48 publications

Health Effects of Metals in Particulate Matter

Health Effects of Metals in Particulate Matter

Sex-based differences in lymphocyte proliferation in the spleen after vanadium inhalation

Thymic cytoarchitecture changes in mice exposed to vanadium

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