Vanadium compounds in medicine

Abstract

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The Role of Vitamin C in the Protection and Modulation of Genotoxic Damage Induced by Metals Associated with Oxidative Stress

“…As a consequence, substances with antioxidant properties emerge as putative preventatives and co-adjuvants in the treatment of chronic degenerative diseases related to oxidative stress and DNA damage [41]. Additionally, the promising low costs of vanadium-based drugs make it particularly atractive, and the ability to overcome the adverse efects of vanadium compounds during therapeutic action is an urgent and crucial issue for its future use in medicine [49]. Our indings strongly suggest that vitamin C can be used efectively in therapy either alone (antioxidant) or in combination with other agents such as V 2 O 5 to reduce their genotoxicity [8].…”

“…In contrast, high levels Vitamin Cof ROS are cytotoxic to the cells and trigger apoptotic mechanisms. Therefore, it has been proposed that the cytotoxic efects of vanadium compounds should be used to generate ROS and reactive nitrogen species to combat cancer cell lines [48,49]. Of all the proposed mechanisms of V(V) toxicity, the induction of oxidative stress is of particular importance for biological systems [50,51].…”

Polysaccharides and their vanadium complexes: new therapeutic perspectives by their ability of modulating macrophages

“…Vanadium exhibits several important biological effects [9,10] and has been suggested to be an excellent target for antiparasitic purposes, including antileishmanial action [11][12][13][14] .…”

“…In addition to the studies with native polymers, different types of chemically modified polysaccharides, including the complexation with metals aiming at different applications, has been investigated [3] . The complexation of carbohydrate biopolymers with different metals is facilitated mainly due to the presence of hydroxyl groups in these polymers and, in some instances, the presence of charged groups such as carboxyl or sulfate [4][5][6][7][8] .Vanadium exhibits several important biological effects [9,10] and has been suggested to be an excellent target for antiparasitic purposes, including antileishmanial action [11][12][13][14] .Plant polysaccharides have received great interest in medicine mainly due to their availability, low cost, and low toxicity [15] . Many of these biopolymers are biological response modifiers, in particular able to modulate macrophages to produce immunomodulatory mediators like cytokines and nitrogen and oxygen radicals such as nitric oxide (NO) and superoxide anion, respectively.…”

Effects of vanadium on oxidative stress and electrolytes balance of dyslipidemic male rats treated with simvastatin

“…Overall, vanadium therapy was shown to normalize blood glucose levels in diabeticinduced rats and was also shown to cure many hyperglycaemia-related disorders (Liu et al, 2013). Some other researchers have investigated the toxcicity of vanadium compounds depending on oxidation state, administration, route of exposure, dose and the sensitivity of the organism (Pessoa et al, 2015). Besides its potential pharmaceutics, vanadium is also used as a dietary supplement for enhancing athletic performance.…”