Vanadium

Crans, Debbie C.; Smee, Jason J.

doi:10.1016/b0-08-043748-6/03030-9

Cited by 23 publications

(29 citation statements)

References 827 publications

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“…In both cases, the complexes presented an octahedral geometry, where four molecules of water or pyridine, depending on the study, surrounded the vanadium atom and protected the metallic center providing enough stability to obtain the XRD (X-ray diffraction) structures [29,30]. V(III) ions, on one hand, hydrolyze in aqueous solution forming mononuclear and polynuclear species, where at pH close to neutrality, the trimer V 3 (OH) 8 + becomes predominant [15,[31][32][33]. V (III) complexes with biogenic ligands that possess donor sulfur atoms in aqueous solution are hydrolysable at high pH values, and may form polynuclear species [24].…”

Section: Chemical Speciation With (Non)essential Aminoacidsmentioning

confidence: 99%

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications

Carpio

Hernández

Ciangherotti

et al. 2018

Coordination Chemistry Reviews

102

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a b s t r a c tIn the last 30 years, since the discovery that vanadium is a cofactor found in certain enzymes of tunicates and possibly in mammals, different vanadium-based drugs have been developed targeting to treat different pathologies. So far, the in vitro studies of the insulin mimetic, antitumor and antiparasitic activity of certain compounds of vanadium have resulted in a great boom of its inorganic and bioinorganic chemistry. Chemical speciation studies of vanadium with amino acids under controlled conditions or, even in blood plasma, are essential for the understanding of the biotransformation of e.g. vanadium antidiabetic complexes at the physiological level, providing clues of their mechanism of action. The present article carries out a bibliographical research emphaticizing the chemical speciation of the vanadium with different amino acids and reviewing also some other important aspects such as its chemistry and therapeutical applications of several vanadium complexes.

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Section: Chemical Speciation With (Non)essential Aminoacidsmentioning

confidence: 99%

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications

Carpio

Hernández

Ciangherotti

et al. 2018

Coordination Chemistry Reviews

102

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“…The chemistry of high-valent vanadium is dominated by oxido-species, including the oxide halides VO 2 X (X = F or Cl) and VOX 3 (X = F, Cl or Br). [1,4] Complexes of VOCl 3 with a variety of hard mono-(L) and bidentate (L-L), N-and O-donor ligands have been prepared; mostly they are intensely coloured five-([VOCl 3 L]) or six-coordinate ([VOCl 3 L 2 ] or [VOCl 3 (L-L)]), highly moisture-sensitive and the vanadium is easily reduced to lower oxidation states. [5][6][7][8] 6 ].…”

Section: Introductionmentioning

confidence: 99%

Complexes of Vanadium(V) Oxide Trifluoride with Nitrogen and Oxygen Donor Ligands: Coordination Chemistry and Some Fluorination Reactions

et al. 2008

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Abstract[VOF3(MeCN)], obtained by dissolving VOF3 in dry acetonitrile, is a useful synthon for the preparation of complexes of the oxide‐fluoride, and the reaction with 2,2′‐bipyridyl, 1,10‐phenanthroline, Me2N(CH2)2NMe2 and Ph2P(O)CH2P(O)Ph2 (L–L), or Ph3PO, Me3PO, Ph3AsO, pyridine and pyridine N‐oxide (L), produces the complexes [VOF3(L–L)] or [VOF3(L)2] respectively. These were characterised by microanalysis, IR, UV/Vis and multinuclear NMR [51V, 19F{1H}, 31P{1H}, 1H] spectroscopy, the data showing them to besix‐coordinate with trans F–V–F units and the neutralligands trans to O and F, respectively. X‐ray crystal structures of [VOF3(1,10‐phenanthroline)], [VOF3(Ph3PO)2] and [VOF3(pyNO)2] confirm the geometry, although the first two exhibit O/F disorder trans to the neutral ligand. Unstable complexes with ether and thioether ligands including [VOF3{MeO(CH2)2OMe}], [VOF3{MeS(CH2)2SMe}] and [VOF3(15‐crown‐5)] are also described; these decompose rapidly even in the solid state, with fluorination of the ligands. The [VOF3(Ph3AsO)2] also decomposes in solutionto a mixture of products including Ph3AsF2 and [V6O12F4(Ph3AsO)2(Ph2AsO2)2] identified crystallographically. Comparisons with complexes of VOCl3 are also described.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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“…[33][34][35][36][37][38] The octahedral geometry around the vanadium center is slightly distorted and the tripodal nitrogen V-N2 distance of 2.3877(17) Å is significantly longer than the sidearm N1-V bond of 2.2261(17) Å as the result of a trans effect of the oxido group. The vanadium-oxido distance is comparable to those in known structures, [39,40] with V-O6 = 1.5904 (15) Cytotoxicity of compounds 1 and 2 was measured on HT-29 human colon and OVCAR-3 human ovarian cancer cells. In addition, similar experiments were performed with human ovarian A2780 cells (parent cisplatin-sensitive cells) and A2780cis cells (with acquired cisplatin resistance), in order to gain more insight into the cytotoxicity pattern of these compounds.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic Vanadium Complexes of Branched [ONNO]‐Type Diamine Bis(phenolato) Ligands

et al. 2017

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Vanadium complexes are attractive potential alternatives to platinum-based anticancer drugs. Two vanadium(V) complexes, based on a common chelating tetradentate diaminobis(phenolato) ligand featuring a branched connectivity but differing in their labile ligands, were synthesized and characterized. Whereas the isopropoxido complex was obtained as a mixture of cis and trans isomers with regard to the orientation of the labile group vs. the amine sidearm, the salicylato-containing complex was obtained as a single trans isomer. X-ray

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Vanadium

Cited by 23 publications

References 827 publications

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications

Complexes of Vanadium(V) Oxide Trifluoride with Nitrogen and Oxygen Donor Ligands: Coordination Chemistry and Some Fluorination Reactions

Cytotoxic Vanadium Complexes of Branched [ONNO]‐Type Diamine Bis(phenolato) Ligands

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