Values of Three Different Preoperative Regimens in Comprehensive Treatment For Young Patients with Stage Ib2 Cervical Cancer

Abstract

Cervical cancer tends to occur at an early age. Treatment for cervical cancer includes surgery, chemotherapy, radiotherapy or their combination. The 2-year survival of early cervical cancer after surgery or chemoradiothearpy reaches over 80%. Stage Ib2 cervical cancer, however, is a high-risk early stage cervical cancer with easy recurrence and metastasis. Its 5-year survival is as low as about 50%. Thus how to increase survival and decreases mortality of stage Ib2 cervical cancer is a hot spot in genealogical cancer research. Materials and Methods General dataOne hundred and twelve young patients below 35 years with stage Ib2 cervical cancer were enrolled retrospectively in our hospital from January, 2003 to June, 2005. They ranged in age from 20 to 35 years with a median age of 32 years. The cases of cervical cancer were all confirmed as invasive cancer by our Department of Pathology, including (Group 1, n=38), the neoadjuvant chemotherapy (Group 2, n=49), and the intracavity brachytherapy group (Group 3, n=25). Radical hysterectomy was performed following these regimens. Chemotherapy and radiotherapy were given according to pelvic lymph node metastasis, deep cervical stromal invasion, intravascular cancer emboli, histological grading, vaginal stump and positive surgical margin. Results: The cancer disappearance and superficial muscle invasion rates were statistically significantly better in the concurrent chemoradiotherapy group than in the other two groups (P<0.01). No statistically significant difference was noted in the deep muscle invasion rate, surgical time and intraoperative blood loss among three groups, but significantly more postoperative complications occurred in the concurrent chemoradiotherapy group. The 2-year pelvic recurrence was statistically significantly lower in the concurrent chemoradiotherapy group compared to other two groups, while the 5-year survival was higher. Conclusion: Concurrent chemoradiotherapy is efficacious for young patients with stage Ib2 cervical cancer.

ADH7, miR‑3065 and LINC01133 are associated with cervical cancer progression in different age groups

“…However, lymphatic metastasis, postoperative recurrence and other toxic side effects, including secondary infection, radiation damage and malnutrition all have an adverse effect on therapeutic outcomes (14). Therefore, it is essential to investigate novel and effective prognostic indicators and therapeutic targets to improve cervical cancer therapy (15). MicroRNAs (miRNAs) are a group of endogenous short noncoding RNAs consisting of ~22 nucleotides that cause the degradation of mRNA by targeting the 3' untranslated region (16,17).…”

Long noncoding RNA MEG3 is downregulated in cervical cancer and affects cell proliferation and apoptosis by regulating miR-21

“…The prognosis of advanced patients generally remains poor and the overall 5 y survival rate is approximately 40% after conventional treatments are used. 3 Thus, effective therapeutic strategy is urgently needed and further exploring the mechanism underlying is urgently required.…”

Impact of Hyperglycemia on Outcomes among Patients Receiving Neoadjuvant Chemotherapy for Bulky Early Stage Cervical Cancer

“…Because a well-organized, nation-wide screening system has not been established in most developing countries, cervical cancer always cannot be detected at an early stage or in a precancerous situation [2]. In fact, 70% of new cases in these countries are diagnosed at an advanced stage [3]. For patients with bulky early stage cervical cancer (BESCC), concurrent chemoradiotherapy (CCRT) has been the primary treatment [1].…”