Values for tissue magnesium as a guide in detecting magnesium deficiency

Lim, Pin; Jacob, Edward; Dong, S.; Khoo, Oon Teik

doi:10.1136/jcp.22.4.417

Cited by 52 publications

(25 citation statements)

References 19 publications

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“…It was shown in the human that the serum Mg concentration is significantly decreased during the third trimester of pregnancy (LIM et a!.,1969). It was argued that Mg deficiency may be the cause of spasmophilic gravid uterus, and administration of Mg reduces uterine hyperexcitability (AIKAWA, 1981).…”

Section: Discussionmentioning

confidence: 99%

Effects of magnesium on the membrane activity and contraction of the circular muscle of rat myometrium during late pregnancy.

Osa

Ogasawara

1983

Jpn.J.Physiol

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Comparative effects of Mg were studied on circular muscle strips of pregnant rat myometrium near term and during delivery. Frequency and amplitude of spontaneous contraction were markedly depressed by adding 0.6 mM Mg to Mg-free Krebs solution in the muscle strips taken in the morning of Days 19 and 22 of pregnancy. Frequency decreased, whereas the amplitude was not depressed by 0.6 mM Mg in muscle strips taken during delivery. Plateau potential dominated in the circular muscle taken in the morning on Days 19 and 22, and it was depressed by Mg, leaving the evoked spike potential nearly unaffected. Burst of spike potentials dominated in the circular muscle during delivery, and 0.6 mM Mg did not affect the burst discharge. In contrast to the variable effects of 0.6 mM Mg on the polarized muscle strips of different pregnant stages, application of Mg (0.6-3.6 mM) caused commonly a potentiation of tonic contraction of K-contracture generated in muscle strips of any pregnant stage. Prolonged perfusion with Mg-free Krebs solution (several hours) of the muscle strip taken in the morning on Day 22 caused a transformation of membrane activity from a plateau dominant type to a spike dominant one. With the same procedure, the depressant effect of Mg on phasic contractions was progressively decreased.

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Section: Discussionmentioning

confidence: 99%

Effects of magnesium on the membrane activity and contraction of the circular muscle of rat myometrium during late pregnancy.

Osa

Ogasawara

1983

Jpn.J.Physiol

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“…In the estimation of serum ultrafiltrable magnesium, the method of preparing serum ultrafiltrate previously described was used [10]. Skeletal muscle and erythrocyte magnesium were estimated as previously described [9]. Bone magnesium was estimated in the same way as for skeletal muscle magnesium.…”

Section: Methodsmentioning

confidence: 99%

Magnesium Status in Chronic Uraemic Patients

Lim¹

1972

Nephron

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Magnesium level in bone, skeletal muscle, the erythrocyte, serum and serum ultrafiltrate were estimated in ten patients with advanced uraemia. Eight patients were found to have significantly low skeletal muscle magnesium, indicating significant deficit of the cation. However, there was no correlation between skeletal muscle magnesium and magnesium levels of the other tissues. Bone magnesium was normal in all patients as was erythrocyte magnesium. Serum magnesium level was variable, but 6 of the 8 patients with low skeletal muscle magnesium had normal magnesium level in their serum ultrafiltrate. Although clinical features that might be attributed to magnesium deficiency were frequently seen in the uraemic patients, there is no discernible difference in clinical pattern between patients with or without magnesium deficiency as shown by skeletal muscle magnesium estimation.

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“…Muscle Mg concentration is considered as a good indicator for Mg status (Lim et al, 1969;Dyckner and Wester, 1985). Muscle Mg is lost during Mg deprivation (Drenick et al, 1969;Wallach, 1988;Lukaski and Nielsen, 2002) and an average of 15% of skeletal-muscle Mg can become available for extracellular buffering (Wallach, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, a much lower dose can be administered by injection over a few minutes in an ambulatory setting. For validation, muscle Mg concentration was used as the accepted reference technique, being a reliable indicator for Mg status (Lim et al, 1969;Dyckner and Wester, 1985).…”

Section: Introductionmentioning

confidence: 99%

Urinary excretion of an intravenous 26Mg dose as an indicator of marginal magnesium deficiency in adults

et al. 2005

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Background: Measurement of magnesium (Mg) status is problematic because tissue Mg deficiency can be present without low serum Mg concentrations. Objective: To evaluate a modified version of the Mg retention test using stable isotopes for the assessment of Mg status in general, and the detection of marginal Mg deficiency in particular. Design: A modified version of the Mg retention test using a small dose of 26 Mg was evaluated for assessment of Mg status in 22 healthy subjects. Muscle Mg concentration was used as reference for Mg status. A muscle biopsy was taken from the lateral portion of the quadriceps muscle from each subject. After 2 to 4 weeks, 11 mg of 26 Mg (as MgCl 2 in 14 ml water) were injected i.v. over a period of 10 min and all urine was collected for the following 24 h. Excretion of the isotopic label was expressed as percentage of the administered dose excreted in urine within 24 h. Results: Mean7s.d. Mg concentration in muscle was 3.8570.17 mmol/100 g fat-free dried solids. Mean7s.d. excretion of the injected dose within 24 h was 7.972.1%. No correlation was found between muscle Mg concentration and excretion of the isotopic label (r 2 ¼ 0.061, P ¼ 0.27). Conclusions: In this study, urinary excretion of an intravenous Mg tracer was not influenced by muscle Mg concentration and its usefulness for the detection of marginal Mg deficiency could therefore not be demonstrated. Sponsorship:

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Values for tissue magnesium as a guide in detecting magnesium deficiency

Cited by 52 publications

References 19 publications

Effects of magnesium on the membrane activity and contraction of the circular muscle of rat myometrium during late pregnancy.

Effects of magnesium on the membrane activity and contraction of the circular muscle of rat myometrium during late pregnancy.

Magnesium Status in Chronic Uraemic Patients

Urinary excretion of an intravenous 26Mg dose as an indicator of marginal magnesium deficiency in adults

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