Values for serum procalcitonin, C-reactive protein, and soluble triggering receptor expressed on myeloid cells-1 in predicting survival of patients with early-onset stroke-associated pneumonia

Xie, Jian‐Wei; Zhang, X H; Zhu, Wei

doi:10.4238/2015.may.11.4

Cited by 7 publications

(5 citation statements)

References 14 publications

(13 reference statements)

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“…In the process of lung inflammation, sTREM-1 is an indispensable regulator. In normal lung tissues, sTREM-1 is selectively expressed by pathogen-clearing alveolar macrophages and is upregulated in the presence of bacteria and fungi [33,34]. Studies have shown that the expression level of sTREM-1 in bronchial lavage fluid of patients with community-acquired pneumonia and hospital-acquired pneumonia is significantly higher than that of healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that the expression level of sTREM-1 in bronchial lavage fluid of patients with community-acquired pneumonia and hospital-acquired pneumonia is significantly higher than that of healthy controls. In addition, the level of sTREM-1 is correlated with the positive rate of blood culture and sputum culture in patients with community-acquired pneumonia, indicating that serum sTREM-1 can be used as an independent inflammatory indicator of pneumonia [34,35]. CXCL-16 can chemotactically recruit lymphocytes by binding to its receptor CXCR6 to participate in the body's immune regulation [36].…”

Section: Discussionmentioning

confidence: 99%

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Serum sTREM-1 and CXCL-16 Levels in Children with Mycoplasma pneumoniae Pneumonia and Their Diagnostic Value

Fang

Mao

Jiang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Mycoplasma pneumoniae pneumonia (MPP) is an acute respiratory tract infection caused by Mycoplasma pneumoniae. It is characterized by severe symptoms, long course of disease, many intrapulmonary complications, and poor therapeutic effect. In recent years, the incidence of Mycoplasma infection have been gradually rising trend, and the children’s own immune system development is not mature, cases differences, children with mild can only show the upper respiratory tract infection, and critically ill children can lead to lung infection and even lead to multiple organ dysfunction, affect life and health of children. Soluble triggering receptors expressed on myeloid cell-1 (sTREM-1) is a subtype secreted by myeloid cell trigger receptor-1, which is released into blood in large amounts when the body is infected, and is a newly discovered inflammatory indicator in recent years. CXC chemokine 16 (CXCL-16) can recruit lymphocytes by chemotaxis through binding to its receptor CXCR6 to participate in the body’s immune regulation. The purpose of this study was to investigate serum sTREM-1 and CXCL-16 levels in children with MPP and to analyze their correlation with the disease and diagnostic value. The results showed that the serum levels of sTREM-1 and CXCL-16 were increased in children with Mycoplasma. Serum levels of sTREM-1 and CXCL-16 were positively correlated with the severity of the disease. sTREM-1 combined with CXCL-16 has an important value in the diagnosis of children with MPP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum sTREM-1 and CXCL-16 Levels in Children with Mycoplasma pneumoniae Pneumonia and Their Diagnostic Value

Fang

Mao

Jiang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…In these studies, inflammatory biomarkers, such as the neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR), were explored to predict SAP (Cheng et al, 2020;Nam et al, 2018). C-reactive protein (CRP), interleukin-6 (IL-6), and procalcitonin (PCT) have also been shown to be associated with SAP and can be used as predictors of SAP (Kwan et al, 2013;Xie et al, 2015). The hypersensitive C-reactive protein-albumin ratio (CAR) is calculated from hypersensitive C-reactive protein (Hs-CRP), and albumin (ALB) has been reported…”

Section: Introductionmentioning

confidence: 99%

“…In these studies, inflammatory biomarkers, such as the neutrophil‐to‐lymphocyte ratio (NLR) and monocyte‐to‐lymphocyte ratio (MLR), were explored to predict SAP (Cheng et al., 2020 ; Nam et al., 2018 ). C‐reactive protein (CRP), interleukin‐6 (IL‐6), and procalcitonin (PCT) have also been shown to be associated with SAP and can be used as predictors of SAP (Kwan et al., 2013 ; Xie et al., 2015 ). The hypersensitive C‐reactive protein‐albumin ratio (CAR) is calculated from hypersensitive C‐reactive protein (Hs‐CRP), and albumin (ALB) has been reported as a new and sensitive marker and is associated with poor outcomes in patients with tumors or cancer, critically ill patients, and patients with various brain diseases, such as spontaneous intracerebral hemorrhage (Bender et al., 2020 ; Park et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Hypersensitive C‐reactive protein‐albumin ratio is associated with stroke‐associated pneumonia and early clinical outcomes in patients with acute ischemic stroke

Huang

Zhang

et al. 2022

Brain and Behavior

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Objectives:We aimed to explore the association between the baseline hypersensitive C-reactive protein-albumin ratio (CAR) and stroke-associated pneumonia (SAP) during hospitalization and the short-term prognosis in patients with acute ischemic stroke (AIS). Methods:We enrolled 766 patients with AIS and collected their admission baseline characteristics, including their National Institutes of Health Stroke Scale score, CAR, age, atrial fibrillation, dysphagia, sex, stroke severity (A 2 DS 2 ) score, and other information. The occurrence of SAP within 7 days after stroke, length of hospital stay, and physical condition at discharge were also recorded. The patients' Modified Rankin Scale (mRS) scores and mortality 3 months after AIS were further evaluated at followup. All patients were divided into four groups based on the quartiles of the admission CAR (Q1 <1.3, Q2 1.3-3.7, Q3 3.7-9.3, Q4 ≥9.3).Results: During hospitalization, 92 (11.9%) patients were diagnosed with SAP. The patients with SAP had a higher CAR than the non-SAP patients (p < .001). In the multivariate-adjusted model, the patients in the Q3 and Q4 groups had a higher SAP risk (aOR was 5.21 and 17.72, p-trend < .001) than those in the lowest quartile. The area under the curve for the CAR's ability to predict SAP was 0.810 in the receiver operating characteristic curve analysis and had a similar predictive efficacy as the A 2 DS 2 score (p <.05). The length of stay in the SAP group was almost the same as that in the non-SAP group, but the clinical outcomes were worse at discharge and at the 3-month follow-up in the SAP group. In addition, the patients in the higher CAR quartiles at admission were more likely to have poorer clinical outcomes. Conclusions:Patients with AIS with a high CAR at admission are more likely to develop SAP during hospitalization and have poor short-term clinical outcomes. These findingsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…However, stroke is often accompanied by an inflammatory response that could lead to an imbalance in the system that regulates body temperature; this may increase body temperature, reduce immunity, and increase the risk of pathogenic infection and invasion of the lungs, thus aggravating the inflammatory response and immune response disorders. Collectively, these events may lead to a further increase in body temperature and the levels of CRP and PCT, thus increasing the risk of pneumonia ( 18 ). OASIS is a comprehensive evaluation index based on 10 parameters, including age, body temperature, and urine volume on the 1st day of ICU.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of the Oxford Acute Severity of Illness Score in acute stroke patients with stroke-associated pneumonia

Wang,

Xia,

Shan

et al. 2023

Front. Neurol.

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BackgroundStroke-associated pneumonia (SAP) is associated with a poor prognosis and a high mortality rate in stroke patients. However, the accuracy of early prediction of SAP is insufficient, and there is a lack of effective prognostic evaluation methods. Therefore, in this study, we investigated the predictive value of the Oxford Acute Severity of Illness Score (OASIS) in SAP to provide a potential reference index for the incidence and prognosis of SAP.MethodsWe recruited a total of 280 patients with acute ischemic stroke who had been diagnosed and treated in the Zhumadian Central Hospital between January 2021 and January 2023. These patients were divided into an SAP group (86 cases) and a non-SAP group (194 cases) according to SAP diagnostic criteria by expert consensus on the diagnosis and treatment of SAP. We collated general and clinical data from all patients, including the survival of SAP patients during the follow-up period. Multivariate logistic regression was used to analyze the risk factors for SAP. Kaplan–Meier and multivariate COX regression analyses were used to investigate the relationship between OASIS and the prognosis of SAP, and a receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of OASIS for SAP.ResultsOur analyses identified body temperature, C-reactive protein, procalcitonin, OASIS, and a prolonged length of intensive care unit (ICU) stay as the main risk factors for SAP (all Ps < 0.05). Advanced age and an elevated OASIS were identified as the main risk factors for death in SAP patients (all Ps < 0.05). The risk of death in patients with OASIS of 31–42 points was significantly higher than that in patients with OASIS of 12–20 points (HR = 5.588, 95% CI = 1.531–20.401, P = 0.009). ROC curve analysis further showed that OASIS had a high predictive value for morbidity and the incidence of death in SAP patients.ConclusionOASIS can effectively predict the onset and death of SAP patients and provides a potential reference index for early diagnosis and the prediction of prognosis in patients with SAP. Our findings should be considered in clinical practice.

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Values for serum procalcitonin, C-reactive protein, and soluble triggering receptor expressed on myeloid cells-1 in predicting survival of patients with early-onset stroke-associated pneumonia

Cited by 7 publications

References 14 publications

Serum sTREM-1 and CXCL-16 Levels in Children with Mycoplasma pneumoniae Pneumonia and Their Diagnostic Value

Serum sTREM-1 and CXCL-16 Levels in Children with Mycoplasma pneumoniae Pneumonia and Their Diagnostic Value

Hypersensitive C‐reactive protein‐albumin ratio is associated with stroke‐associated pneumonia and early clinical outcomes in patients with acute ischemic stroke

Predictive value of the Oxford Acute Severity of Illness Score in acute stroke patients with stroke-associated pneumonia

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