Value of whole body MRI and dynamic contrast enhanced MRI in the diagnosis, follow-up and evaluation of disease activity and extent in multiple myeloma

Dutoit, Julie C.; Vanderkerken, Matthias; Verstraete, Koenraad

doi:10.1016/j.ejrad.2013.04.012

Cited by 73 publications

(61 citation statements)

References 28 publications

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“…In patients with solid tumors, it has become a valuable tool to quantify treatment response beyond measuring tumor size. However, there are only few studies including small numbers of heterogeneous patient groups that used DCE-MRI for the longitudinal assessment of antiangiogenic treatment response in multiple myeloma (16,17).…”

Section: Introductionmentioning

confidence: 99%

Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Assessment of Antiangiogenic Treatment Effects in Multiple Myeloma

Merz

Ritsch

Kunz

et al. 2015

Clinical Cancer Research

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Purpose: To noninvasively assess bone marrow microcirculation before and after therapy in patients with newly diagnosed multiple myeloma with dynamic contrast-enhanced MRI (DCE-MRI).Experimental Design: Ninety-six patients received DCE-MRI before and after primary treatment for newly diagnosed multiple myeloma. For the 91 evaluable patients, treatment consisted of high-dose therapy (HDT) with autologous stem cell transplantation (ASCT) in 82 patients and chemotherapy without ASCT in 9 patients. In addition, 33 healthy volunteers were imaged as the control group. Analysis of DCE-MRI was performed according to the two-compartment model by Brix to quantify amplitude A (associated with blood volume) and exchange rate constant k ep (reflecting vessel permeability and perfusion).Results: Nonresponders showed significantly higher A-values before the start of therapy compared with responders (P ¼ 0.02). In both responders and nonresponders to therapy, A-values dropped significantly (P ¼ 0.004 and <0.001, respectively) after primary therapy, whereas lower values for k ep were found only in responders (P < 0.001). Depth of remission was significantly correlated to decreased bone marrow microcirculation: Patients in near complete response (nCR) or complete remission (CR) after treatment showed significantly lower values for A compared with patients not achieving nCRþCR. The application of HDT or novel agents had no significant effect on DCE-MRI parameters after therapy, although patients treated with novel agents more often achieved nCRþCR (42%/12.5%; P < 0.002). Higher k ep -values at second MRI were positively correlated to shorter overall survival (HR 3.53; 95% confidence intervals, 1.21-10.33; P ¼ 0.02).Conclusion: Parameters from DCE-MRI are correlated to remission after primary therapy and outcome in newly diagnosed multiple myeloma.

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Section: Introductionmentioning

confidence: 99%

Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Assessment of Antiangiogenic Treatment Effects in Multiple Myeloma

Merz

Ritsch

Kunz

et al. 2015

Clinical Cancer Research

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“…18 F-fluoro-2-deoxy-D-glucose positron emission tomography ( 18 FDG-PET) and 18 FDG-PET/computed tomography (CT) allow a complete picture of active intra-and extrapulmonary sites [4]. Whole-body magnetic resonance imaging (WB-MRI) is an established diagnostic tool for multifocal disorders such as multiple myeloma and metastatic diseases [5,6]. The role of WB-MRI in the assessment of extrathoracic organ involvement in patients with sarcoidosis has not yet been studied.…”

Section: Whole-body Magnetic Resonance Imaging In Extrathoracic Sarcomentioning

confidence: 99%

Whole-body magnetic resonance imaging in extrathoracic sarcoidosis

Hostettler¹,

Bratu

Fischmann

et al. 2014

European Respiratory Journal

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“…The disease evolves from an asymptomatic stage, monoclonal gammopathy of undetermined significance (MGUS), and progresses over smouldering myeloma (sMM) to symptomatic MM disease (2).…”

Section: Introduction Introductionmentioning

confidence: 99%

“…Imaging evaluation of patients with MM is very important for the assessment of the extent and severity of disease at presentation, identification of complications and assessment of therapy response (2). Magnetic resonance imaging (MRI) is increasingly used in the diagnosis of multiple myeloma, and the recent consensus statement of the International Myeloma Working Group (IMWG) introduced the role of Whole-body Magnetic resonance imaging (WB-MRI) in the management of patients with this haematological disease (3).…”

Section: Introduction Introductionmentioning

confidence: 99%

Whole Body MRI Evaluation in Patients with Multiple Myeloma: A Must

Buzoianu¹,

Lupescu²,

Preda³

2017

SGO

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Magnetic resonance imaging (MRI) is increasingly used in the diagnosis of multiple myeloma (MM). The new statement of the International Myeloma Working Group (IMWG) introduced the role of Whole-body Magnetic Resonance Imaging (WB-MRI) in the management of patients with this haematological disease. We report the case of a hospitalized patient in the haematology department, who was diagnosed with MM and investigated by WB-MRI in order to achieve a complete lesions' report, and staging of the disease. The presented case illustrates more lesions of the spine, long bones and the skull. Common MRI characteristics of MM lesions were defined as a nodular injuries, which were hypointense with T1-weighting, hyperintense with STIR and/or hyperintense with b-800 diffusion-weighting. WB-MRI examination was shown to be a sensitive imaging technique in evaluation of bone marrow and it was included in the DurieSalmon staging system PLUS.

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Value of whole body MRI and dynamic contrast enhanced MRI in the diagnosis, follow-up and evaluation of disease activity and extent in multiple myeloma

Cited by 73 publications

References 28 publications

Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Assessment of Antiangiogenic Treatment Effects in Multiple Myeloma

Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Assessment of Antiangiogenic Treatment Effects in Multiple Myeloma

Whole-body magnetic resonance imaging in extrathoracic sarcoidosis

Whole Body MRI Evaluation in Patients with Multiple Myeloma: A Must

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