“…Thus, image-guided Diagnostic precision of multisampling CNB P Loubeyre et al large-cutting CNB has been proposed as the initial procedure for the diagnosis of deep-seated lymphomas (de Kerviler et al, 2000;Demharter et al, 2001;Balestreri et al, 2005;Li et al, 2005;SklairLevy et al, 2005;Lachar et al, 2007;de Larrinoa et al, 2007), and in some institutions for suspect peripheral lymph nodes (Screaton et al, 2002;de Kerviler et al, 2007). Although variable endpoints were analysed in those studies with highly diverse designs, CNB appears to be a valuable approach with sensitivity for diagnosing lymphoma at 87 -89% (Demharter et al, 2001;Balestreri et al, 2005), overall diagnostic yield at 84% , unequivocal diagnosis of lymphoma at 91% (Lachar et al, 2007), overall diagnostic accuracy for lymphoma typing at 88% (de Larrinoa et al, 2007), sufficient information such that a therapeutic decision could be made at 96% (de Kerviler et al, 2007) and diagnosis of lymphoma with subtyping ranging from 76 to 85% (de Kerviler et al, 2000;Li et al, 2005). However, the validity of CNB for lymphoma diagnosis is still controversial, and entire lymph node removal is often proposed as the best procedure Engert and Dreyling, 2008;Tilly and Dreyling, 2008).…”