Value of Transnasal Esophagoscopy in the Workup of Laryngo-Pharyngeal Reflux

Horvath, Lukas; Fostiropoulos, Karolos; Burri, Emanuel; Kraft, Marcel

doi:10.3390/jcm10143188

Cited by 5 publications

(13 citation statements)

References 19 publications

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“…These are important checkpoints for the inhibition of refluxate ascension into the laryngopharynx, and their functionality plays an important role in the prevention of reflux. 5,6 In daily life, abdominal pressure rises with every inspiration, which significantly contributes to the pathophysiology of reflux, but remains hidden during sedation. Similarly, active abdominal pressure cannot be performed by the sedated patient to unmask a LES weakness.…”

Section: Discussionmentioning

confidence: 99%

“…We used the same technique as previously described. 6 Gathering of pathological findings (Table 2) was performed in a systematic manner according to our protocol.…”

Section: Transnasal Esophagoscopymentioning

confidence: 99%

“…Gaseous reflux in LPR is predominantly symptomatic in the throat, while fluid reflux in GER mainly produces tissue injury in the distal oesophagus. 6 However, both GER and LPR can be present at the same time, in which case damage is caused within the oesophagus and the laryngopharynx as well. 3 The gold standard for diagnosing GER is esophagogastroduodenoscopy (EGD) and impedance pH-monitoring (PHM).…”

Section: Introductionmentioning

confidence: 99%

“…TNE with its considerable benefits has been used for a while as an additional method to assess LPR. 6 Although a direct comparison between these two endoscopic methods performed in the same patient has been performed before, a comparison of EGD and TNE for reflux assessment has not been described so far. Hence, the objective of our study was to compare TNE and EGD in contributing to the diagnosis of LPR.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of transnasal esophagoscopy and sedated esophagogastroduodenoscopy in the assessment of laryngopharyngeal reflux

Horvath

Fostiropoulos

Burri

et al. 2022

Clinical Otolaryngology

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Objective Transnasal esophagoscopy (TNE) in the awake patient and esophagogastroduodenoscopy (EGD) in sedation are both used in the assessment of laryngopharyngeal reflux (LPR). The objective of this study was to compare these two endoscopic methods in contributing to the diagnosis of LPR. Methods This study included 54 patients presenting with signs and symptoms suspicious for LPR, which were examined both by TNE and EGD. The contribution of each method to the diagnosis of LPR was evaluated separately and then compared with each other. Results In detecting LPR, TNE showed a significant higher sensitivity (94% vs. 60%) and accuracy (93% vs. 59%) than EGD, but their specificity was equal (50% each). The most common pathologic findings in both methods were a hiatal hernia (70% vs. 48%) and gaping cardia (69% vs. 24%), followed by peptic esophagitis (41% vs. 24%). Conclusion The value of EGD is limited in the workup of LPR, as sedation tends to mask the subtle findings in this kind of reflux disease.

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Section: Discussionmentioning

confidence: 99%

“…We used the same technique as previously described. 6 Gathering of pathological findings (Table 2) was performed in a systematic manner according to our protocol.…”

Section: Transnasal Esophagoscopymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of transnasal esophagoscopy and sedated esophagogastroduodenoscopy in the assessment of laryngopharyngeal reflux

Horvath

Fostiropoulos

Burri

et al. 2022

Clinical Otolaryngology

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“…It is recognized as a clinical disorder that differs from the classic gastroesophageal reflux disease (GERD). 2 Furthermore, LPR occurs mainly in the upper respiratory tract, mainly in the hypopharynx and larynx region, whereas GERD is due to gastric and duodenal reflux into the esophagus, resulting in acid reflux and heartburn. 3,4 OSAHS is reported to be a commonly occurring sleep-breathing disorder, with about 3-7% of general adults suffering from it.…”

Section: Introductionmentioning

confidence: 99%

Laryngopharyngeal Reflux in Obstructive Sleep Apnea-Hypopnea Syndrome: An Updated Meta-Analysis

He¹,

Wang²,

Li³

2022

NSS

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Laryngopharyngeal reflux (LPR) is a common disorder in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). This meta-analysis was carried out to evaluate the LPR prevalence in individuals with OSAHS and to analyze the correlation of LPR positivity with the clinical features of patients with OSAHS. A detailed review of the English and Chinese literature on the occurrence of LPR in patients with OSAHS was performed by employing online search tools such as PubMed, EMBASE, Web of Science, VIP, CNKI, WanFang, etc. Two researchers analyzed the studies for quality according to the STROBE standard checklist. The acquired data were analyzed using Stata 11.0 and R 3.6.1 software. The effect size was estimated and calculated using weighted mean difference (WMD) and correlation coefficients. Moreover, a combined analysis was performed by employing either a random-or fixed-effects model. Ultimately, 27 studies met our inclusion criteria. Our study revealed that the LPR prevalence in OSAHS patients was 49%. We carried out subgroup analyses as per OSAHS severity, ethnicity, and body mass index (BMI). The results suggested that the probability of LPR in European and American patients with OSAHS was higher, and the prevalence of LPR was higher in obese individuals and patients with severe OSAHS. Moreover, apnea-hypopnea index (AHI) and BMI were higher in LPR-positive OSAHS patients than in LPR-negative OSAHS patients, but no significant variation in age was observed in the two groups. Moreover, the reflux symptom index (RSI) scores and the reflux finding score (RFS) exhibited a positive correlation with AHI. The current literature shows a higher incidence of LPR in individuals with OSAHS (49%). The severity of AHI in individuals with OSAHS is associated with the presence of LPR. Patients with OSAHS accompanied by LPR showed higher BMI and AHI as compared to those patients with LPR-negative OSAHS.

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Einsatz der flexiblen transnasalen Ösophagogastroskopie bei Patienten mit unklarem Globus pharyngeus

Podzimek,

Jecker,

Koscielny

et al. 2024

HNO

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Value of Transnasal Esophagoscopy in the Workup of Laryngo-Pharyngeal Reflux

Cited by 5 publications

References 19 publications

Comparison of transnasal esophagoscopy and sedated esophagogastroduodenoscopy in the assessment of laryngopharyngeal reflux

Comparison of transnasal esophagoscopy and sedated esophagogastroduodenoscopy in the assessment of laryngopharyngeal reflux

Laryngopharyngeal Reflux in Obstructive Sleep Apnea-Hypopnea Syndrome: An Updated Meta-Analysis

Einsatz der flexiblen transnasalen Ösophagogastroskopie bei Patienten mit unklarem Globus pharyngeus

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