Value of the SYNTAX Score for Risk Assessment in the All-Comers Population of the Randomized Multicenter LEADERS (Limus Eluted from A Durable versus ERodable Stent coating) Trial

Wykrzykowska, Joanna J.; Garg, Scot; Girasis, Chrysafios; Vries, Ton de; Morel, Marie-Angèle; Es, Gerrit Anne van; Buszman, Paweł; Linke, Axel; Ischinger, Thomas; Klauß, Volker; Corti, Roberto; Eberli, Franz R.; Wijns, William; Morice, Marie‐Claude; Mario, Carlo Di; Geuns, Robert Jan van; Jüni, Peter; Windecker, Stephan; Serruys, Patrick W.

doi:10.1016/j.jacc.2010.03.044

Cited by 206 publications

(141 citation statements)

References 15 publications

Supporting

Mentioning

130

Contrasting

Unclassified

Order By: Relevance

“…Higher mortality rates (low = 1.5%; intermediate = 2.1%; and high = 5.6%; P = 0.002) and higher rates of target-vessel revascularisation were also observed (low = 6.3%; intermediate = 7.8%; and high = 11.3%; P = 0.001). 10 The similarity of the mid-range SYNTAX score of that study with the present analysis is emphasised.…”

Section: Discussionsupporting

confidence: 57%

Impacto do escore SYNTAX na estratificação de risco após intervenção coronária percutânea em pacientes não-selecionados

Barbosa¹,

Costa²,

Feres³

et al. 2012

Rev. Bras. Cardiol. Invasiva

View full text Add to dashboard Cite

Background:The SYNTAX score was developed as an angiographic tool to grade the complexity of coronary artery disease in patients with three-vessel and/or left main disease. The role of this score in predicting clinical outcomes after percutaneous coronary intervention (PCI) in non-selected patients treated in the daily clinical practice of a referral centre was evaluated. Methods: Analysis of patients undergoing PCI from March to September of 2009, and at the 12-month follow-up. Patients were divided into tertiles according to the SYNTAX score. The primary endpoint included major adverse cardiac events (MACE) -death, non-fatal acute myocardial infarction, and target-vessel revascularisation. The ability of the SYNTAX score to predict MACE was assessed by the receiver operator characteristic (ROC) curve. Results: Two hundred and thirty-four patients with a mean SYNTAX score of 11.6 ± 6.2 points were included. Tertile I had a SYNTAX score ≤ 9 (average 5.9); tertile II, > 9 and ≤ 13 (average 10.8); and tertile III, > 13 (average 18.3). During the clinical follow-up of 7.2 ± 4.9 months, the incidence of MACE was greater in tertile III than in tertiles I and II (2.5% vs. 6.4% vs. 14.1%; P = 0.0075). The ROC curve showed an area under the curve of 0.667 (P = 0.012), indicating a moderate ability to anticipate the occurrence of MACE in this population. Conclusions: The SYNTAX score proved to be useful in predicting the occurrence of MACE after PCI in patients treated in clinical practice.

show abstract

Section: Discussionsupporting

confidence: 57%

Impacto do escore SYNTAX na estratificação de risco após intervenção coronária percutânea em pacientes não-selecionados

Barbosa¹,

Costa²,

Feres³

et al. 2012

Rev. Bras. Cardiol. Invasiva

View full text Add to dashboard Cite

show abstract

“…Firstly, it may explain why patients with higher DTS have increased MACE because patients with higher risk DTS have increased SxScore, which has a prognostic value. Secondly, since there was a signi cant positive association between SxScore and periprocedural myocardial necrosis (PPI) during percutaneous coronary intervention, which is associated with worse outcomes including death (10)(11)(12), it may help clinicians with risk stratifying of their patients, before the patients undergo coronary angiography, and to take necessary measures in order to avoid such complications. Our study has important limitations.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Duke Treadmill Score and Coronary Artery Lesion Complexity

Acar¹,

Korkmaz²,

Ağaç³

et al. 2012

CIM

View full text Add to dashboard Cite

Purpose: e purpose of this study was to investigate the relationship between the Duke Treadmil Score (DTS) and coronary artery disease (CAD) complexity in patients with suspected coronary artery disease (CAD).Methods: Sixty ve patients who had positive exercise testing for CAD were enrolled. Coronary angiography was performed and Syntax score (SxScore), a marker of CAD complexity, was determined. e relationship between DTC and SxScore then evaluated.Results: ere was a strong negative correlation between DTS and SxScore (r= -0.91, p< 0.001). In addition, patients with higher and intermediate risk as evaluated by DTS had increased SxScore compare to those that were low risk (23 ± 6, 6 ± 5 and 0 ± 0 respectively).Conclusions: A strong negative correlation was seen between DTS and coronary lesion complexity. By assessing DTS important information about coronary artery lesion complexity can be obtained before invasive coronary angiography.

show abstract

“…Originally conceived as a scoring system for angiographic extent and complexity of coronary artery disease (CAD) 1 , the SYNTAX score (SS) has been correlated with the risk of adverse events after percutaneous coronary intervention (PCI) in patients receiving early-and new-generation drug-eluting stents (DES) [2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

Angiographic complexity of coronary artery disease according to SYNTAX score and clinical outcomes after revascularisation with newer-generation drug-eluting stents: a substudy of the BIOSCIENCE trial

Franzone¹,

Taniwaki²,

Rigamonti³

et al. 2016

EuroIntervention

Self Cite

View full text Add to dashboard Cite

Aims: We sought to assess the performance of drug-eluting stents combining an ultrathin cobalt-chromium platform with a biodegradable polymer across categories of increasing SYNTAX score (SS). Methods and results:Patients included in the BIOSCIENCE trial and randomly allocated to treatment with biodegradable polymer sirolimus-eluting stents (BP-SES) or durable polymer everolimus-eluting stents (DP-EES) were categorised according to SS tertiles (low <8, medium 8-15, high >15). The primary endpoint, target lesion failure (TLF), was defined as a composite of cardiac death, target vessel myocardial infarction and clinically indicated target lesion revascularisation. The patient-oriented endpoint (POCE) included death, myocardial infarction, or any repeat revascularisation. The SS was available in 2,041 out of 2,119 patients (96.3%). At two-year follow-up, patients with an SS >15 experienced higher rates of both TLF and POCE as compared to patients with medium and low SS (14.5% vs. 8.1% and vs. 5.9%, p<0.001; 22.7% vs. 14.9% and vs. 12.4%; p<0.001), respectively. Comparable rates of the composite endpoints were documented for both stent types in each category of SS.Conclusions: Increasing lesion complexity as assessed by SS was associated with higher rates of TLF and POCE in a contemporary PCI population with minimal exclusion criteria. BP-SES and DP-EES showed comparable performance across the entire spectrum of CAD severity. KEYWORDS• biodegradable polymer sirolimuseluting stents • coronary artery disease • durable polymer everolimus-eluting stents • SYNTAX score

show abstract

Value of the SYNTAX Score for Risk Assessment in the All-Comers Population of the Randomized Multicenter LEADERS (Limus Eluted from A Durable versus ERodable Stent coating) Trial

Abstract: The SXscore, when applied to an all-comers patient population treated with drug-eluting stents, may allow prospective risk stratification of patients undergoing percutaneous coronary intervention. (LEADERS Trial Limus Eluted From A Durable Versus ERodable Stent Coating; NCT00389220).

Cited by 206 publications

References 15 publications

Impacto do escore SYNTAX na estratificação de risco após intervenção coronária percutânea em pacientes não-selecionados

Impacto do escore SYNTAX na estratificação de risco após intervenção coronária percutânea em pacientes não-selecionados

Relationship Between Duke Treadmill Score and Coronary Artery Lesion Complexity

Angiographic complexity of coronary artery disease according to SYNTAX score and clinical outcomes after revascularisation with newer-generation drug-eluting stents: a substudy of the BIOSCIENCE trial

Contact Info

Product

Resources

About