Value of the Frontal Assessment Battery Tool for Assessing the Frontal Lobe Function in Stroke Patients

Han, Mi-Hyang; Kim, Da Ye; Leigh, Ja Ho

doi:10.5535/arm.19111

Cited by 16 publications

(14 citation statements)

References 36 publications

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“…[ 15 , 16 ] The secondary outcome measure was the change in ADL, assessed by the Korean version of the Modified Barthel Index (MBI). [ 1 , 17 , 18 ]…”

Section: Methodsmentioning

confidence: 99%

Graded motor imagery training as a home exercise program for upper limb motor function in patients with chronic stroke

Ji¹,

Wang²,

Jung³

et al. 2021

Medicine

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Purpose: Although several types of occupational therapy for motor recovery of the upper limb in patients with chronic stroke have been investigated, most treatments are performed in a hospital or clinic setting. We investigated the effect of graded motor imagery (GMI) training, as a home exercise program, on upper limb motor recovery and activities of daily living (ADL) in patients with stroke. Methods: This prospective randomized controlled trial recruited 42 subjects with chronic stroke. The intervention group received instruction regarding the GMI program and performed it at home over 8 weeks (30 minutes a day). The primary outcome measure was the change in motor function between baseline and 8 weeks, assessed the Manual Function Test (MFT) and Fugl-Meyer Assessment (FMA). The secondary outcome measure was the change in ADL, assessed with the Modified Barthel Index (MBI). Results: Of the 42 subjects, 37 completed the 8-week program (17 in the GMI group and 20 controls). All subjects showed significant improvements in the MFT, FMA, and MBI over time (P < .05). However, the improvements in the total scores for the MFT, FMA, and MBI did not differ between the GMI and control groups. The MFT arm motion score for the GMI group was significantly better than that of the controls (P < .05). Conclusions: The GMI program may be useful for improving upper extremity function as an adjunct to conventional rehabilitation for patients with chronic stroke.

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“…[ 15 , 16 ] The secondary outcome measure was the change in ADL, assessed by the Korean version of the Modified Barthel Index (MBI). [ 1 , 17 , 18 ]…”

Section: Methodsmentioning

confidence: 99%

Graded motor imagery training as a home exercise program for upper limb motor function in patients with chronic stroke

Ji¹,

Wang²,

Jung³

et al. 2021

Medicine

View full text Add to dashboard Cite

show abstract

“…Even so, the results showed us significant losses in all functionality domains, as well as in some cognitive domains found mainly in EF as seen in Table 10-12. Some cognitive impairments persist even after remission of the symptoms, and many studies have shown that they are neuropsychologically related, at least in part, to the psychosocial difficulties of these patients [91]; [88]; [158]. On the contrary, there is little data in the literature about the use of the FAB test in bipolar patients, and it is difficult to correlate this data with the anatomical lesions analyzed.…”

Section: Discussionmentioning

confidence: 99%

Assessment of different domain impairments in Cognitive Functions and Functionalities found in Euthymic Patients with Bipolar Disorder I / II - during the early and late phases of the disease, using the FAB and FAST tests.

Cyrino¹,

Calegari²,

Tomasi³

et al. 2021

IJAERS

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In this study, we focus on assessing two key predictors and outcomes in Bipolar Disorder (BD), which are: cognition and functionality performance, dividing them into two subgroups, and then researching for a correlation between them. Methods; Fifty patients with BD in a euthymic phase were divided into two subgroups (≤ 3 years (n=25) and ≥ 10 years (n=25) of the disease) and were then compared with healthy controls (n=25). Psychosocial functioning was assessed using the Short Functionality Assessment Test (FAST), and the Frontal Assessment Battery (FAB) test to assess frontal cognitive functions. Clinical and sociodemographic characteristics were analyzed using unilateral variance analysis, or the chi-square test. In order to verify the correlation between the FAB and FAST tests, Spearman's correlation coefficient test was used Results: Both subgroups of euthymic patients had higher FAST total scores than the healthy control group (9.80 ± 5.94). The groups with ≤ 3 years (20.63 ± 8.21), and ≥ 10 years (27.80 ± 12.50) of the disease presented(p<0.001). Associated with these results, bipolar patients had higher FAST scores in all domains, predominantly with moderate impairment (score 21-40), and lower scores in the following four FAB test domains: conceptualization, sensitivity to interference, inhibitory control, and motor series (p<0.05). The correlation between the FAB and FAST tests showed moderate intensity (r 2 = -0.539). Conclusion: This study reinforced the impact of BD on functionality and frontal cognitive functions, demonstrating changes in several domains, and impairment in social, occupational, and cognitive functions in patients with different times of disease onset. Understanding all factors is essential for these patients, which increases the possibility of rehabilitation and response to treatment.

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“…The superior and middle gyri of the frontal lobe are the functional areas during calculation (Wang and Wang, 2001). Moreover, Han et al (2020) reported that patients with stroke with frontal cortex involvement had a lower MMSE score in the calculation category than healthy controls after adjustment for age. Since the correlation between NfL and the total MMSE was lacking, the causes for the cognitive impairment in ESRD might be more than neurodegeneration.…”

Section: The Role Of Nfl For Risk Assessment For Cognitive Impairmentmentioning

confidence: 99%

The Role of Plasma Neurofilament Light Protein for Assessing Cognitive Impairment in Patients With End-Stage Renal Disease

Hou

Huang

et al. 2021

Front. Aging Neurosci.

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Introduction: End-stage renal disease (ESRD) is defined as the irreversible loss of renal function, necessitating renal replacement therapy. Patients with ESRD tend to have more risk factors for cognitive impairment than the general population, including hypertension, accumulative uremic toxin, anemia, and old age. The association between these risk factors and the pathologic protein was lacking. Blood-based assays for detecting pathologic protein, such as amyloid beta (Aβ), total tau protein, and neurofilament light chain (NfL), have the advantages of being less invasive and more cost-effective for diagnosing patients with cognitive impairment. The aim of the study is to validate if the common neurologic biomarkers were different in ESRD patients and to differentiate if the specific biomarkers could correlate with specific correctable risk factors.Methods: In total, 67 participants aged >45 years were enrolled. The definition of ESRD was receiving maintenance hemodialysis for >3 months. Cognitive impairment was defined as a Mini-Mental State Examination score of <24. The participants were divided into groups for ESRD with and without cognitive impairment. The blood-based biomarkers (tau protein, Aβ1/40, Aβ1/42, and NfL) were analyzed through immunomagnetic reduction assay. Other biochemical and hematologic data were obtained simultaneously.Summary of results: The study enrolled 43 patients with ESRD who did not have cognitive impairment and 24 patients with ESRD who had cognitive impairment [Mini-Mental State Examination (MMSE): 27.60 ± 1.80 vs. 16.84 ± 6.40, p < 0.05]. Among the blood-based biomarkers, NfL was marginally higher in the ESRD with cognitive impairment group than in the ESRD without cognitive impairment group (10.41 ± 3.26 vs. 8.74 ± 2.81 pg/mL, p = 0.037). The concentrations of tau protein, amyloid β 1/42, and amyloid β 1/40 (p = 0.504, 0.393, and 0.952, respectively) were similar between the two groups. The area under the curve of NfL to distinguish cognitively impaired and unimpaired ESRD patients was 0.687 (95% confidence interval: 0.548–0.825, p = 0.034). There was no correlation between the concentration of NfL and MMSE among total population (r = −0.153, p = 0.277), patients with (r = 0.137, p = 0.583) or without cognitive impairment (r = 0.155, p = 0.333).Conclusion: Patients with ESRD who had cognitive impairment had marginally higher plasma NfL concentrations. NfL concentration was not correlated with the biochemical parameters, total MMSE among total population or individual groups with or without cognitive impairment. The concentrations of Aβ1/40, Aβ1/42, and tau were similar between the groups.

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Value of the Frontal Assessment Battery Tool for Assessing the Frontal Lobe Function in Stroke Patients

Cited by 16 publications

References 36 publications

Graded motor imagery training as a home exercise program for upper limb motor function in patients with chronic stroke

Graded motor imagery training as a home exercise program for upper limb motor function in patients with chronic stroke

Assessment of different domain impairments in Cognitive Functions and Functionalities found in Euthymic Patients with Bipolar Disorder I / II - during the early and late phases of the disease, using the FAB and FAST tests.

The Role of Plasma Neurofilament Light Protein for Assessing Cognitive Impairment in Patients With End-Stage Renal Disease

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