Value of the Diffusion-Weighted MRI in the Differential Diagnostics of Malignant and Benign Kidney Neoplasms – Our Clinical Experience

Abstract

SummaryBackgroundDiffusion-weighted imaging (DWI) is an MRI modality using strong bipolar gradients to create a sensitivity of the signal to the thermally-induced Brownian motions of water molecules and in vivo measurement of molecular diffusion. The apparent diffusion coefficient (ADC) is a quantitative parameter calculated from DWI images which is used as a measure of diffusion. DWI allows to obtain comprehensive information on morphological and functional state of the kidney during a single examination without contrast medium administration. The purpose of the study was to evaluate the value of DWI in differentiating benign and malignant solid kidney tumors based on the initial stage of the study.Material/MethodsThe study included 19 adult patients with pathologically verified renal tumors: 9 patients with clear cell subtype of the renal cell carcinoma, 5 patients with oncocytoma and 5 patients with angiomyolipoma (AML). In addition, 5 healthy volunteers with completely normal findings according to kidney ultrasound were included into this study and set as reference. All patients underwent renal MR imaging which included DWI with subsequent ADC measurement. MR imaging was performed with a 1.5 T body scanner using an eight-channel phased-array body coil.ResultsThe mean ADC value of ccRCC was significantly lower than that of normal renal parenchyma (2.11±0.25×10−3 mm2/s vs. 3.36±0.41×10−3 mm2/s, p<0.01). There was a significant difference in ADC between the malignant and benign renal lesions: in patients with angiomyolipoma the ADC value was 2.36±0.32×10−3 mm2/s vs. 2.11±0.25×10−3 mm2/s; p<0.05 and in patients with oncocytoma – 2.75±0.27×10−3 mm2/s vs. 2.11±0.25×10−3 mm2/s; p<0.05. The difference in ADC values in patients with high and low ccRCC grades was observed.ConclusionsDWI can be used to characterize renal lesions; the ADC of a renal lesion can be potentially used as an additional parameter to help determine the appropriate clinical management.

Comparison of Biexponential and Monoexponential Model of Diffusion-Weighted Imaging for Distinguishing between Common Renal Cell Carcinoma and Fat Poor Angiomyolipoma

“…This difficulty might arise from considerable variation and overlap between the ADC values of fat poor AMLs and malignant renal lesions. In common subtypes of RCCs, published ADC values varied from 1.23 × 10 -3 mm 2 /s to 2.11 × 10 -3 mm 2 /s in ccRCCs, 0.61 × 10 -3 mm 2 /s to 2.07 × 10 -3 mm 2 /sec in pRCCs, and 0.99 × 10 -3 mm 2 /s to 1.74 × 10 -3 mm 2 /s in chRCCs, respectively (131726293031). However, the reported ADC values of fat poor AMLs showed a significant overlap with that of malignant renal lesions, ranging from 0.72 × 10 -3 mm 2 /s to 1.11 × 10 -3 mm 2 /s (151617).…”

Whole lesion quantitative CT evaluation of renal cell carcinoma: differentiation of clear cell from papillary renal cell carcinoma

“…The less invasive technique to differentiate between ccRCC from pRCC is either CECT or MRI. Diffusion-weighted MRI has been shown to be potentially useful in distinguishing malignant and benign renal neoplasms (Mytsyk et al 2014 ; Agnello et al 2013 ).…”

A Computational Study of Potential miRNA-Disease Association Inference Based on Ensemble Learning and Kernel Ridge Regression

“…Kidney Neoplasms, also known as renal cancer, accounts for about 3% of all adult neoplasms and its incidence rate is also increasing (Gonzalez-Satue et al, 2015). About 87% KN cases in adults were Renal cell carcinoma (RCC) that is the most common malignant epithelial tumor (Mytsyk et al, 2014). Some miRNA-KN associations have been revealed by experimental studies.…”