Value of the determination of TNF-α in the plasma of patients with non-hodgkin's lymphoma

Maciá, J.; Gómez, Xavier; Esquerda, Aureli; Perez, B. Baños; Callao, V.; Marzo, C

doi:10.3109/10428199609052433

Cited by 16 publications

(11 citation statements)

References 21 publications

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“…Previous studies suggest higher expression of TNF-α is associated with NHL risk at the time of diagnosis [14–17]. These studies do not contradict the results of TNF-α-308A allele inducing higher constitutively TNF-α expression associated with decreased NHL risk in Asians.…”

Section: Resultssupporting

confidence: 60%

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Different Role of Tumor Necrosis Factor-α Polymorphism in Non-Hodgkin Lymphomas among Caucasian and Asian Populations: A Meta-Analysis

Zhai

Ding

Zhou

2014

IJMS

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Tumor necrosis factor-α (TNF-α) is an immunoregulatory cytokine involved in B- and T-cell function, and also plays an important role in inflammation and cancer. TNF-α-308G>A has been associated with constitutively elevated TNF-α expression. Several studies have reported the association between the TNF-α-308G>A polymorphism and non-Hodgkin lymphomas (NHL) risk, however, results are still inconsistent. To solve these conflicts, we conducted the first meta-analysis to assess the effect of TNF-α-308G>A polymorphism on the risk of NHL and various subtypes (additive model) including 10,619 cases and 12,977 controls in Caucasian and Asian populations. Our meta-analysis indicated that TNF-α-308G>A polymorphism is not associated with NHL risk when pooling all studies together (OR = 1.06, 95% CI: 0.92–1.23, p = 0.413). In stratified analyses, we found TNF-α-308A allele was significantly associated with higher risk of NHL, B-cell lymphomas (BCL), T-cell lymphomas (TCL) and diffuse large B-cell lymphomas (DLBCL) in Caucasians (OR = 1.22, 95% CI: 1.06–1.40, p = 0.007; OR = 1.18, 95% CI: 1.03–1.34, p = 0.014; OR = 1.20, 95% CI: 1.01–1.42, p = 0.040; OR = 1.21, 95% CI: 1.11–1.32, p < 0.001, respectively). Interestingly, it was associated with decreased risk of NHL, BCL and DLBCL in Asians (OR = 0.75, 95% CI: 0.66–0.86, p < 0.001; OR = 0.70, 95% CI: 0.52–0.94, p = 0.018; OR = 0.70, 95% CI: 0.57–0.86, p = 0.001). These findings also suggest TNF-α might play a distinct role in pathogenesis of NHL in different populations.

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Section: Resultssupporting

confidence: 60%

“…Increased serum values of TNF-α have been detected in autoimmune disease and many malignancies including lymphomas [14–17]. TNF-α-308G>A (rs1800629) SNP has increased susceptibility to many kinds of tumors and autoimmune diseases, such as hepatocellular carcinoma, myeloma, lymphoma, ulcerative colitis, and Crohn’s disease [18–20].…”

Section: Introductionmentioning

confidence: 99%

Different Role of Tumor Necrosis Factor-α Polymorphism in Non-Hodgkin Lymphomas among Caucasian and Asian Populations: A Meta-Analysis

Zhai

Ding

Zhou

2014

IJMS

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“…Our results suggest that the pathophysiological mechanisms of slightly elevated transglomerular passage of albumin may share common pathways with the APPR and inflammatory mediators. Several studies have demonstrated that serum levels of proinflammatory cytokines correlate with important clinical features in haematological malignancies such as tumour stage and disease progression (Macia et al, 1996;Kurzrock, 1997;Warzocha et al, 1997). Our data have confirmed that IL-6 and TNF-alpha are associated with markers of disease activity and adverse prognostic features such as clinical stage, IPI, presence of B symptoms and the level of serum lactate dehydrogenase.…”

Section: Uaementioning

confidence: 99%

Mediators of inflammation correlate with microalbuminuria in patients with non‐Hodgkin's lymphoma

Pedersen

Sørensen

2003

Br J Haematol

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Summary. Recent studies have demonstrated a high frequency of minor glomerular leakage of albumin in cancer patients. Pathogenic mechanisms of increased urinary albumin excretion (UAE) in malignancies remain to be clarified. We have attempted to identify whether microalbuminuria in lymphoma patients is associated with inflammatory mediators and the acute‐phase response. UAE, urinary excretion of β2‐microglobulin and IgG, and serum levels of interleukin 6 (IL‐6), tumour necrosis factor alpha (TNF‐alpha) and C‐reactive protein (CRP) were determined in 113 patients with newly diagnosed non‐Hodgkin's lymphoma. We demonstrated a high frequency of microalbuminuria (≥ 20 μg/min) and UAE correlated strongly with serum levels of CRP, IL‐6 and TNF‐alpha. UAE, CRP, IL‐6 and TNF‐alpha were significantly higher in patients with advanced disease stage, B symptoms and in high‐risk patients according to the International Prognostic Index. Urinary excretion of β2‐microglobulin was unaffected in patients with increased UAE. However, UAE was significantly correlated with urinary excretion of IgG, suggesting an altered size selectivity of the glomerular filtration barrier. This is the first study that shows a direct correlation between microalbuminuria and proinflammatory cytokines in malignancies, indicating a pathogenic relationship between inflammation and glomerular leakage of albumin. Future efforts should focus on the pathophysiological cause–effect mechanisms and larger studies are needed to confirm the clinical significance of UAE.

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“…In addition, they can be detected as soluble TNF receptors in the circulation [3, 4]. Studies in humans have shown that the sTNF-R 75 rather than the sTNF-R 55 serum concentrations are linked to TNF system activity in several diseases such as chronic heart failure [5], malaria [6]and lymphoma [7, 8, 9]. Therefore, we assessed sTNF-R 75 serum concentrations as a marker of TNF activity in patients with cirrhosis of the liver.…”

Section: Introductionmentioning

confidence: 99%

Elevated Soluble Tumour Necrosis Factor Receptor Serum Concentrations and Short-Term Mortality in Liver Cirrhosis without Acute Infections

Reichel

Sudhop²,

Braun³

et al. 2000

Digestion

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Background: Serum concentrations of the soluble 75-kDa tumour necrosis factor receptor (sTNF-R 75) are elevated in patients with severe liver disease and may be linked to mortality as well as to prognostic markers related to clinical outcome and metabolic functions in patients with liver cirrhosis. Patients and Methods: We prospectively studied the relation of sTNF-R 75 to Child-Pugh score points and serum markers of bile acid (total serum bile acids and 7α-hydroxycholesterol), lignocaine (lignocaine metabolite (MEGX) liver function test results) and albumin metabolism (albumin and prealbumin) in 10 healthy individuals and 30 patients with cirrhosis, all free of acute infections. In patients with cirrhosis mortality was recorded for 15 months. Results: Soluble TNF-R 75 concentrations correlated with Child-Pugh score points (r = 0.440, p = 0.015), MEGX test results (r_S = –0.604, p < 0.001) and prealbumin (r_S = –0.527, p < 0.001) in cirrhosis. Nonsurviving patients had almost threefold higher median sTNF-R 75 concentrations (29 ng/ml) than survivors (11 ng/ml) (p = 0.003). Soluble TNF-R 75 serum concentrations with an optimal cut off > 14 ng/ml were significantly more accurate in predicting patient mortality than Child-Pugh score points in a receiver-operator characteristic curve analysis. Conclusion: Soluble TNF-R 75 serum concentrations appear to be a promising new risk factor for mortality in patients with cirrhosis without acute infections.

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Value of the determination of TNF-α in the plasma of patients with non-hodgkin's lymphoma

Cited by 16 publications

References 21 publications

Different Role of Tumor Necrosis Factor-α Polymorphism in Non-Hodgkin Lymphomas among Caucasian and Asian Populations: A Meta-Analysis

Different Role of Tumor Necrosis Factor-α Polymorphism in Non-Hodgkin Lymphomas among Caucasian and Asian Populations: A Meta-Analysis

Mediators of inflammation correlate with microalbuminuria in patients with non‐Hodgkin's lymphoma

Elevated Soluble Tumour Necrosis Factor Receptor Serum Concentrations and Short-Term Mortality in Liver Cirrhosis without Acute Infections

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