Value of the Bronchodilator Response in Assessing Controller Naïve Asthmatic Children

Galant, Stanley P.; Morphew, Tricia; Amaro, Silvia; Liao, Otto

doi:10.1016/j.jpeds.2007.05.004

Cited by 61 publications

(53 citation statements)

References 32 publications

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“…According to this criterion, it was found that 47 (34.1%) of 138 children with asthma exhibited a positive BDR. This is in line with previous reports that a large proportion of patients with asthma do not show a positive BDR, which strengthens the suggestion that BDR provides only modest sensitivity in confirming the diagnosis of asthma [21].…”

Section: Discussionsupporting

confidence: 92%

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Bronchial hyperresponsiveness to methacholine/AMP and the bronchodilator response in asthmatic children

Suh¹,

Lee²,

Kim³

et al. 2010

Eur Respir J

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Bronchodilator response (BDR) is assessed to estimate the reversibility of airflow obstruction. Bronchial hyperresponsiveness (BHR) is a characteristic feature of asthma and is usually measured by means of bronchial challenges using direct or indirect stimuli. The aim of the present study was to compare BHR to methacholine (direct) and that to adenosine 5'-monophosphate (AMP) (indirect) with regard to their relationships to BDR in asthmatic children.Methacholine and AMP challenge tests were performed on 138 children with mild-to-moderate asthma, and the provocative concentration causing a 20% decline in forced expiratory volume in 1 s (FEV1) (PC20) was determined for each challenge. BDR was calculated as the change in FEV1, expressed as a percentage of the initial value, after inhalation of 400 mg salbutamol.Methacholine PC20 correlated significantly but weakly with BDR (r5 -0.254; p50.003). However, there was a significant and strong correlation between AMP PC20 and BDR (r5 -0.489; p50.000). For AMP PC20, the relationship was closer than for methacholine PC20 (p50.024 for comparison between correlation coefficients). The same figures were observed when BDR was expressed as a percentage of the predicted value.A stronger correlation of BDR with AMP PC20 than with methacholine PC20 suggests that BDR may be better reflected by BHR as assessed by AMP challenge than by methacholine challenge.

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Section: Discussionsupporting

confidence: 92%

“…TANTISIRA et al [20] reported a mean BDR of 10.07% among the 1,041 participants in the Childhood Asthma Management Program. GALANT et al [21] observed various mean BDRs according to clinical severity, ranging from 7.3 (mild intermittent group) to 10.1% (severe persistent group).…”

Section: Discussionmentioning

confidence: 99%

Bronchial hyperresponsiveness to methacholine/AMP and the bronchodilator response in asthmatic children

Suh¹,

Lee²,

Kim³

et al. 2010

Eur Respir J

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show abstract

“…11---16 However, the studies that included preschooler spirometry reported only FEV 1 12---15 and in two of them, spirometry was performed using standardised criteria for adults. 12,15 The objective of the present study was to evaluate the utility of measured bronchodilator response to short beta-2 agonists for asthma diagnosis in Chilean preschoolers using spirometry standardised for this specific age group.…”

Section: Introductionmentioning

confidence: 99%

Utility of bronchodilator response for asthma diagnosis in Latino preschoolers

Linares

Peirano

Estay

et al. 2014

Allergologia et Immunopathologia

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“…Die Aussagekraft von FEV 1 als Parameter für den Schweregrad bei kindlichem Asthma wird in pädiatrischen Kreisen seit einiger Zeit kontrovers diskutiert [6,7,8]. Ein Grund, warum der FEV 1 -Wert auch bei Kindern mit schwerer Behinderung der Atemwege normal bleibt, könnte die Tatsache sein, dass bei Kindern der Durchmesser der Atemwege im Vergleich zum Lungenvolumen grösser ist als bei Erwachsenen.…”

Section: Resultateunclassified

Efeu-Extrakt als Zusatzmedikation bei kindlichem Asthma bronchiale

Bachmann¹

2015

Schweiz Z Ganzheitsmed

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Value of the Bronchodilator Response in Assessing Controller Naïve Asthmatic Children

Cited by 61 publications

References 32 publications

Bronchial hyperresponsiveness to methacholine/AMP and the bronchodilator response in asthmatic children

Bronchial hyperresponsiveness to methacholine/AMP and the bronchodilator response in asthmatic children

Utility of bronchodilator response for asthma diagnosis in Latino preschoolers

Efeu-Extrakt als Zusatzmedikation bei kindlichem Asthma bronchiale

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