Value of Speckle Tracking Echocardiography for Detection of Clinically Silent Left and Right Ventricular Dysfunction in Patients with β-Thalassemia Major

Abstract

Background: Since beta-thalassemia is a genetic condition with a variety of clinical manifestations, there has been an increase in interest in biomarkers that could aid in the early identification, staging, and prognosis of cardiac disease in beta-thalassemia patients. Recent advances in quantitative ultrasound technology have made speckle tracking echocardiography a viable option for precisely assessing cardiac function. Aim of the work: Determine the efficacy of Speckle Tracking Echocardiography (STE) in the early diagnosis of myocardial affection in B-Thalassemia patients utilizing various echocardiographic modalities. Methodology: 100 patients between the ages of 5 and 25 were enrolled in a cross-sectional study, 50 of them had known beta thalassemia.